Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araujo Souto, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Summary: Chagas disease is a long-standing disease that primarily affects impoverished populations in Latin America. The available drugs have limited effectiveness and intense side effects. This study explores the biological activity of two new series of pyrazole-thiazoline derivatives with potential therapeutic options against Trypanosoma cruzi. These derivatives show potent activity with good oral bioavailability and low cytotoxicity, making them potential candidates for Chagas disease therapy.
Article
Genetics & Heredity
Hans Desale, Pierre Buekens, Jackeline Alger, Maria Luisa Cafferata, Emily Wheeler Harville, Claudia Herrera, Carine Truyens, Eric Dumonteil
Summary: The study assessed the epigenetic effects of in utero exposure to maternal Trypanosoma cruzi infection. By comparing the DNA methylation patterns of umbilical cord blood cells from uninfected babies with chagasic and uninfected mothers, a differential DNA methylation signature was identified. The genes affected are related to hematopoietic cell differentiation, immune response, and developmental disorders.
Article
Infectious Diseases
A. Abras, C. Ballart, A. Fernandez-Arevalo, T. Llovet, M. Gallego, C. Munoz
Summary: The study evaluated two algorithms for the diagnosis of chronic and congenital Chagas disease, with CMIA showing potential as a single diagnostic test in non-endemic countries and the revised algorithm with the >= 6 S/CO proving to be an efficient method for chronic CD diagnosis. For infants with congenital infection, CMIA could potentially be used as a single test for screening at 10 months or earlier, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
Mariana C. Pagotti, Herbert J. Dias, Ana Carolina B. B. Candido, Thais A. S. Oliveira, Alexandre Borges, Nicoli D. Oliveira, Carla D. Lopes, Renato P. Orenha, Renato L. T. Parreira, Antonio E. M. Crotti, Lizandra G. Magalhaes
Summary: Chagas disease, a neglected tropical disease, affects over 8 million people. Although current therapies have limited effectiveness and high toxicity, the search for new drugs remains important. In this study, neolignans were synthesized and evaluated for their activity against Trypanosoma cruzi strains. Four neolignans demonstrated activity against the T. cruzi strain, with DBN 1 exhibiting the highest activity. In silico analysis showed that these compounds could destabilize tubulin-microtubule interactions. These compounds have potential as molecular prototypes for developing new antiparasitic drugs.
Article
Pharmacology & Pharmacy
Johny Wysllas de Freitas Oliveira, Mariana Farias Alves da Silva, Igor Zumba Damasceno, Hugo Alexandre Oliveira Rocha, Arnobio Antonio da Silva Junior, Marcelo Sousa Silva
Summary: This study investigated the encapsulation of sodium diethyldithiocarbamate (DETC) by poly-lactic acid (PLA) in nanoparticles for the treatment of Chagas disease caused by Trypanosoma cruzi. The nanoparticles showed reduced toxicity against cells and maintained antiparasitic activity. The physical characterization of the nanoparticles demonstrated a small size and negative zeta potential. The encapsulated DETC exhibited similar efficacy against T. cruzi as the free form.
Article
Biochemistry & Molecular Biology
Natalia Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane Franca da Silva, Denise da Gama Jaen Batista, Stenio Fragoso, Gabriel Melo de Oliveira, Maria de Nazare Correia Soeiro, Otacilio C. Moreira
Summary: In this study, genetically modified strains of Trypanosoma cruzi were used to evaluate the role of NTPDases in parasite infectivity. The results showed that parasites overexpressing TcNTPDase-1 had higher infectivity, while hemi-knockout parasites had lower infectivity and no significant electrocardiographic changes. These findings highlight the potential of NTPDases as a therapeutic target for Chagas disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gevanio Bezerra de Oliveira Filho, Marcos Verissimo de Oliveira Cardoso, Aline Caroline da Silva Santos, Thiago Andre Ramos dos Santos, Ana Catarina Cristovao-Silva, Laura Gonzalez Rubio, Luiz da Silva Maia Neto, Paulo Gaio Leite, Fabiana Simao Machado, Luiz Carlos Alves, Fabio Andre Brayner, Valeria Rego Alves Pereira, Ana Cristina Lima Leite
Summary: Chagas disease is causing more deaths in the Americas than any other parasitic disease and is increasingly becoming a global health problem. A novel series of 4-thiazolidinones derivatives have shown increased anti-T. cruzi activity, indicating potential for treating the disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Public, Environmental & Occupational Health
Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy, Raul Fernandez-Naranjo, Esteban Gamez-Rivera, Andrea Tello-De-la-Torre, Galo S. Guerrero-Castillo, Carlos Ruiz-Sosa, Esteban Ortiz-Prado
Summary: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, transmitted through contact with triatomine insect feces and urine. It infects approximately 6-7 million people worldwide, causing at least 14,000 deaths annually. In Ecuador, it has been reported in 20 out of 24 provinces, with El Oro, Guayas, and Loja being the most affected.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Fanny Mathias, Youssef Kabri, Damien Brun, Nicolas Primas, Carole Di Giorgio, Patrice Vanelle
Summary: Chagas disease caused by T. cruzi infection is a major public health problem in Latin America, resulting in 7000 annual deaths. This study synthesized ten new 1-substituted 2-nitropyrrole compounds and evaluated their biological activity. The derivatives showed good selectivity and activity against T. cruzi, but the maximum effect was lower than the reference drug.
Article
Ecology
Zeinab Parsons, Shadi Banitaan
Summary: This research focuses on the automatic identification of Chagas Disease (CD) and proposes four different automated CD vector identification approaches. By utilizing data mining-based methods and convolutional neural networks, the proposed approaches achieved high accuracy rates in classifying kissing bugs. By achieving 100% accuracy rates for the most common dataset of kissing bugs, this study takes a significant step towards overcoming this fatal disease.
ECOLOGICAL INFORMATICS
(2021)
Article
Immunology
Juliana Magalhaes Chaves Barbosa, Yasmin Pedra-Rezende, Luiza Dantas Pereira, Tatiana Galvao de Melo, Helene Santos Barbosa, Joseli Lannes-Vieira, Solange Lisboa de Castro, Anissa Daliry, Kelly Salomao
Summary: The combination treatment of Bz + AMD can attenuate the damage caused by T. cruzi infection in cardiac cells and have a certain control effect on parasite replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Emily A. Kelly, Christina A. Bulman, Emma L. Gunderson, Amanda M. Irish, Rebecca L. Townsend, Judy A. Sakanari, Susan L. Stramer, Caryn Bern, Jeffrey D. Whitman
Summary: The latest-generation CD serology tests may improve diagnostic sensitivity without affecting specificity. Reactivity and sensitivity were highest in samples from donors born in South America and lowest in specimens from those born in Mexico, with intermediate results in specimens from Central American donors.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
