Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 321, Issue 5, Pages 373-376Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2008.09.032
Keywords
Magnetic nanoparticles; Cyclohexane; Cetyl alcohol; Thermal release
Funding
- NSF BME [0730825]
- Medical Device Center, University of Minnesota, Minneapolis, MN
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0730825] Funding Source: National Science Foundation
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The purpose of this study was to explore the properties of coated superparamagnetic nanoparticles (SPNs) specifically for their use in thermal-responsive drug delivery systems. Coated, magnetite SPNs were prepared and dispersed in cyclohexane or cetyl alcohol, a solid lipid at the physiological temperatures of 37 degrees C. The induced temperature change as a function of SPN concentration and external magnetic field and frequency was consistent with theoretical predictions. SPNs dispersed in a solid lipid matrix underwent heating and the associated melting occurred at a temperature suitable for a thermal-responsive drug delivery system. (c) 2008 Elsevier B. V. All rights reserved.
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