Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 37, Issue 6, Pages 1468-1475Publisher
WILEY
DOI: 10.1002/jmri.23927
Keywords
DARTEL; voxel-based morphometry; smoothing kernel; group size
Funding
- Medical Research Council [G0200128] Funding Source: Medline
- MRC [G0200128] Funding Source: UKRI
- Medical Research Council [G0200128] Funding Source: researchfish
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Purpose: To quantify to what extent the new registration method, DARTEL (Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra), may reduce the smoothing kernel width required and investigate the minimum group size necessary for voxel-based morphometry (VBM) studies. Materials and Methods: A simulated atrophy approach was employed to explore the role of smoothing kernel, group size, and their interactions on VBM detection accuracy. Group sizes of 10, 15, 25, and 50 were compared for kernels between 012 mm. Results: A smoothing kernel of 6 mm achieved the highest atrophy detection accuracy for groups with 50 participants and 810 mm for the groups of 25 at P < 0.05 with familywise correction. The results further demonstrated that a group size of 25 was the lower limit when two different groups of participants were compared, whereas a group size of 15 was the minimum for longitudinal comparisons but at P < 0.05 with false discovery rate correction. Conclusion: Our data confirmed DARTEL-based VBM generally benefits from smaller kernels and different kernels perform best for different group sizes with a tendency of smaller kernels for larger groups. Importantly, the kernel selection was also affected by the threshold applied. This highlighted that the choice of kernel in relation to group size should be considered with care. J. Magn. Reson. Imaging 2013;37:14681475. (c) 2012 Wiley Periodicals, Inc.
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