Article
Orthopedics
Bo Ram Kim, Hye Jin Yoo, Hee-Dong Chae, Sung Hwan Hong, Ja-Young Choi
Summary: This study compared the differences between FS T2 and conventional T2 mapping in femoral articular cartilage, finding that the T2 values were significantly lower in FS T2 mapping. Additionally, FS T2 mapping showed higher reproducibility in evaluating knee femoral cartilage compared to conventional T2 mapping.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nick Scholand, Xiaoqing Wang, Volkert Roeloffs, Sebastian Rosenzweig, Martin Uecker
Summary: The purpose of this study is to develop a generic model-based reconstruction framework for multiparametric quantitative MRI. The method uses a nonlinear model to estimate parametric maps directly from the acquired k-space by numerical optimization. The approach combines direct sensitivity analysis and pre-computed state-transition matrices to create a generic framework for calibrationless model-based reconstruction that can be applied to different pulse sequences. The results show that the method is effective in generating accurate T-1 and T-2 maps in various simulations and experiments.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Medicine, General & Internal
Bunyamin Ece, Hasan Yigit, Elif Ergun, Enver Necip Koseoglu, Erdal Karavas, Sonay Aydin, Pinar Nercis Kosar
Summary: This study aimed to assess supraspinatus tendon pathologies using T2/T2* mapping techniques. Significant differences were found in the lateral region of the tendon in the rupture group and the lateral region in the tendinosis group compared to the asymptomatic group. T2 and T2* mapping techniques with 1.5 T MRI can accurately evaluate tendon rupture and tendinosis in the supraspinatus tendon.
Article
Health Care Sciences & Services
Piotr A. Regulski, Jakub Zielinski, Bartosz Borucki, Krzysztof Nowinski
Summary: This study presents an accurate T2 mapping reconstruction method and compares it with another method. The results show that this method performs better in terms of accuracy and goodness of fit.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sean C. L. Deoni, Jonathan O'Muircheartaigh, Emil Ljungberg, Mathew Huentelman, Steven C. R. Williams
Summary: Low magnetic field systems provide an important opportunity for expanding MRI to new clinical and research study populations. However, they have lower signal-to-noise ratios compared to higher field strength systems, resulting in compromises in spatial resolution and imaging time. This study introduces a super-resolution approach to reconstruct high-resolution T-2-weighted images from low-resolution anisotropic images acquired in orthogonal orientations, allowing for simultaneous quantitative T-2 imaging without sacrificing time. The results demonstrate the feasibility and accuracy of this approach in acquiring high-resolution images and quantitative T-2 maps.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tianle Cao, Sen Ma, Nan Wang, Sara Gharabaghi, Yibin Xie, Zhaoyang Fan, Elliot Hogg, Chaowei Wu, Fei Han, Michele Tagliati, E. Mark Haacke, Anthony G. Christodoulou, Debiao Li
Summary: A new technique was developed to quantitatively image multiple parameters of the brain simultaneously and synthesize six contrast-weighted images in a single 9.1-minute scan. The method was validated on phantoms and healthy volunteers, showing good consistency with reference methods. This MR Multitasking-based 3D brain mapping technique is promising for multicontrast and quantitative imaging.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Guijuan Cao, Shubo Gao, Bin Xiong
Summary: This study investigates and compares the values of 3.0 T MRI T1, T2, and T2* mapping quantification techniques in evaluating shoulder joint cartilage degeneration. The results show that the T1, T2, and T2* relaxation values are significantly correlated with the MRI-based grading of cartilage degeneration, and T2 mapping has the highest value among these techniques.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carl J. J. Herrmann, Antje Els, Laura Boehmert, Joao Periquito, Thomas Wilhelm Eigentler, Jason M. Millward, Sonia Waiczies, Joseph Kuchling, Friedemann Paul, Thoralf Niendorf
Summary: This study investigates a new MRI technique for simultaneous generation of quantitative maps of multiple MR contrast mechanisms. Through simulations and experiments, it demonstrates the feasibility of this technique in mimicking brain relaxation times and in healthy subjects. The clinical applicability of this technique in multiple sclerosis patients is also confirmed.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carl J. J. Herrmann, Antje Els, Laura Boehmert, Joao Periquito, Thomas Wilhelm Eigentler, Jason M. Millward, Sonia Waiczies, Joseph Kuchling, Friedemann Paul, Thoralf Niendorf
Summary: This study demonstrates the feasibility of radially (under)sampled 2in1-RARE-EPI for simultaneous T-2 and T2* mapping in MS patients. Good agreement was found between T-2/T2* values derived from 2in1-RARE-EPI and reference values obtained from MSE and MGRE in both phantoms and healthy subjects. In patients, MS lesions in T-2 and T2* maps deduced from 2in1-RARE-EPI could be clearly delineated as in reference maps calculated from MSE/MGRE.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Medicine, General & Internal
Lei Ye, Yayi Wang, Wanxin Xiang, Jin Yao, Jiaming Liu, Bin Song
Summary: The study demonstrated that radiomic mapping could provide more information than direct evaluation of T2 and ADC values in differentiating histological grades of bladder cancer. Among the radiomic models, the T2-mapping radiomic model outperformed the ADC and joint radiomic models.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Serguei M. Liachenko, Natalya V. Sadovova, Arnold Tripp, Suman Ghorai, Anil K. Patri, Joseph P. Hanig, Jonathan E. Cohen, Ira Krefting
Summary: T-2 mapping can detect the effects of gadolinium retention in the rat brain, and intraperitoneal administration is equivalent to intravenous for long-term studies. The presence of gadolinium was confirmed using T-2 mapping and mass spectrometry, and no histopathological abnormalities were observed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Hyungseok Jang, Sam Sedaghat, Jiyo S. Athertya, Dina Moazamian, Michael Carl, Yajun Ma, Xing Lu, Alicia Ji, Eric Y. Chang, Jiang Du
Summary: This study developed an ultrashort echo time quantitative susceptibility mapping technique with an efficient 3D cones trajectory and validated its effectiveness in the human brain. The results showed that this technique provides reliable estimation of magnetic susceptibility and offers a new biomarker for susceptibility mapping in the in vivo brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ruimin Feng, Jiayi Zhao, He Wang, Baofeng Yang, Jie Feng, Yuting Shi, Ming Zhang, Chunlei Liu, Yuyao Zhang, Jie Zhuang, Hongjiang Wei
Summary: In this study, a model-based deep learning architecture called MoDL-QSM was proposed to improve accuracy in quantifying tissue susceptibility in various brain diseases by considering the impact of susceptibility tensors, reducing streaking artifacts. The model integrates convolutional neural networks and a physical model, using phase induced by X-33 and X-13, X-23 terms as network training labels. The results demonstrated superior performance compared to other deep learning QSM methods, showing potential for future applications.
Article
Materials Science, Biomaterials
Chengbin Wang, Chenglin Yan, Lu An, Huifeng Zhao, Shaoli Song, Shiping Yang
Summary: The study introduces ultra-small Fe3O4 nanoclusters as an endogenous GSH-responsive MRI contrast agent for improved tumor diagnosis by utilizing the overexpression of GSH in tumors to achieve T-2/T-1 signal switching.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Clinical Neurology
Erin C. Argentieri, Ek Tsoon Tan, Jeremy S. Whang, Sophie C. Queler, Joseph H. Feinberg, Bin Lin, Darryl B. Sneag
Summary: Quantitative T-2 MR muscle mapping shows potential as a noninvasive tool for evaluating the degree of motor unit recruitment loss.
Article
Biochemistry & Molecular Biology
Hong Pan, Barbara Oliveira, Gesine Saher, Ekrem Dere, Daniel Tapken, Marina Mitjans, Jan Seidel, Janina Wesolowski, Debia Wakhloo, Christina Klein-Schmidt, Anja Ronnenberg, Kerstin Schwabe, Ralf Trippe, Kerstin Maetz-Rensing, Stefan Berghoff, Yazeed Al-Krinawe, Henrik Martens, Martin Begemann, Winfried Stoecker, Franz-Josef Kaup, Reinhard Mischke, Susann Boretius, Klaus-Armin Nave, Joachim K. Krauss, Michael Hollmann, Fred Luhder, Hannelore Ehrenreich
MOLECULAR PSYCHIATRY
(2019)
Article
Chemistry, Multidisciplinary
Tina K. Kaiser, Mikhail Khorenko, Amir Moussavi, Michael Engelke, Susann Boretius, Claus Feldmann, Holger M. Reichardt
JOURNAL OF CONTROLLED RELEASE
(2020)
Editorial Material
Neurosciences
Article
Pharmacology & Pharmacy
Oula Penate Medina, Robert J. Tower, Tuula Penate Medina, Fatma Ashkenani, Lia Appold, Marcus Boetcher, Lukas Huber, Olga Will, Qi Ling, Charlotte Hauser, Arndt Rohwedder, Carola Heneweer, Eva Peschke, Jan-Bernd Hoevener, Kerstin Luedtke-Buzug, Susann Boretius, Rolf Mentlein, Kalevi Kairemo, Claus C. Glueer, Susanne Sebens, Holger Kalthoff
Summary: This study tested the usability of multimodal nanoparticles for pancreatic tumor imaging and drug delivery. The results showed that the nanoparticles could be detected using various imaging techniques such as MRI, optical imaging, and photoacoustic imaging. In vivo experiments demonstrated that the nanoparticles had high accumulation in tumor areas, indicating excellent targeting ability.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Multidisciplinary Sciences
Amir Moussavi, Matthias Mietsch, Charis Drummer, Ruediger Behr, Judith Mylius, Susann Boretius
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Melanie Lohrberg, Anne Winkler, Jonas Franz, Franziska van der Meer, Torben Ruhwedel, Nikoloz Sirmpilatze, Rakshit Dadarwal, Ronja Handwerker, Daniel Esser, Kerstin Wiegand, Christian Hagel, Andreas Gocht, Fatima Barbara Koenig, Susann Boretius, Wiebke Moebius, Christine Stadelmann, Alonso Barrantes-Freer
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Amir Moussavi, Sophie Missbach, Claudia Serrano Ferrel, Hasti Ghasemipour, Kristin Koetz, Charis Drummer, Rudiger Behr, Wolfram-Hubertus Zimmermann, Susann Boretius
Summary: Real-Time (RT) cardiac MRI is a feasible alternative to standard cine MRI for assessing cardiac function in rhesus macaques, with consistent underestimations of functional parameters but high repeatability. Additionally, RT-MRI allows for analysis of cardio-respiratory coupling and reduces experimental effort, measurement time, risk, and burden for animals compared to cine MRI.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rudiger Hardeland, Jan Seidel, Fred Luhder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Summary: Research has shown that encephalitis may be caused by viral infections, leading to neuronal death and subsequent cognitive decline and dementia. In a mouse model, researchers identified various symptoms and brain abnormalities associated with the disease.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Surgery
Lauren C. C. Cassidy, Emily J. J. Bethell, Ralf R. R. Brockhausen, Susann Boretius, Stefan Treue, Dana Pfefferle
Summary: Understanding the impact of routine research and laboratory procedures on animals is vital for their well-being and the success of the research. Cognitive measures of welfare, such as attention bias, can provide insights into the psychological state of animals, but need validation. This study developed a dot-probe task for long-tailed macaques to detect changes in attention bias following anesthesia, and found that attention bias changed to avoidance of threatening content immediately after anesthesia, but returned to threat vigilance by the third day postanesthesia.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Matthias Kettwig, Katharina Ternka, Kristin Wendland, Dennis Manfred Krueger, Silvia Zampar, Charlotte Schob, Jonas Franz, Abhishek Aich, Anne Winkler, M. Sadman Sakib, Lalit Kaurani, Robert Epple, Hauke B. Werner, Samy Hakroush, Julia Kitz, Marco Prinz, Eva Bartok, Gunther Hartmann, Simone Schroeder, Peter Rehling, Marco Henneke, Susann Boretius, A. Alia, Oliver Wirths, Andre Fischer, Christine Stadelmann, Stefan Nessler, Jutta Gaertner
Summary: Infantile-onset RNaseT2 deficient leukoencephalopathy is characterized by cystic brain lesions, white matter alterations, cerebral atrophy, and psychomotor impairment. Studies using Rnaset2(-/-) mice reveal upregulation of interferon-stimulated genes, IFNAR1-dependent neuroinflammation, and insights into hippocampal-accentuated brain atrophy and cognitive impairment. This study provides a potential animal model for investigating CNS damage associated with RNaseT2 deficiency and exploring therapeutic interventions for interferon-driven brain pathology.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Tobias J. Buscham, Maria A. Eichel-Vogel, Anna M. Steyer, Olaf Jahn, Nicola Strenzke, Rakshit Dardawal, Tor R. Memhave, Sophie B. Siems, Christina Muller, Martin Meschkat, Ting Sun, Torben Ruhwedel, Wiebke Mobius, Eva-Maria Kramer-Albers, Susann Boretius, Klaus-Armin Nave, Hauke B. Werner, Kelly Monk
Summary: CMTM5 plays a role in maintaining axonal integrity rather than myelin biogenesis, as its deficiency leads to early-onset progressive axonopathy without affecting the development or ultrastructure of myelin.
Article
Biology
Nikoloz Sirmpilatze, Judith Mylius, Michael Ortiz-Rios, Juergen Baudewig, Jaakko Paasonen, Daniel Golkowski, Andreas Ranft, Ruediger Ilg, Olli Grohn, Susann Boretius
Summary: In this study, researchers used fMRI to map the brain areas involved in anesthesia-induced burst-suppression across different mammalian species. They found distinct burst-suppression patterns in humans, long-tailed macaques, common marmosets, and rats, with rats showing involvement of the entire neocortex and primates excluding most sensory areas. The identified species-specific fMRI signatures and whole-brain maps will assist future studies on the cellular and molecular mechanisms of burst-suppression in unconscious states.
Article
Neurosciences
Rakshit Dadarwal, Michael Ortiz-Rios, Susann Boretius
Summary: The fusion method TQ-SILiCON combines QSM and T1-weighted images to enhance the contrast of cortex and subcortical structures, providing an excellent delineation of white matter. This method has been validated in both macaque monkeys and humans, demonstrating improved segmentation of cortical and subcortical structures.
Article
Veterinary Sciences
Lena Bunzendahl, Amir Moussavi, Martina Bleyer, Jana Dehnert, Susann Boretius, Stephan Neumann
Summary: Osteoarthritis in dogs commonly affects the stifle joint and detecting it early is crucial for effective treatment. Conventional MRI is the standard imaging technique, but quantitative MRI offers a more sensitive method for diagnosing early pathological changes. Menisci play a significant role in joint health, and specialized MRI sequences like T2 relaxation time can identify changes in water content and collagen structures.
VETERINARY SCIENCES
(2023)
Article
Neurosciences
Georg Hafner, Julien Guy, Mirko Witte, Pavel Truschow, Alina Rueppel, Nikoloz Sirmpilatze, Rakshit Dadarwal, Susann Boretius, Jochen F. Staiger
Summary: By investigating the brain-wide input connectivity in reeler mice, it was found that in the absence of cortical layers, cortical neurons establish a different network that largely preserves cognitive functions. The connection with subcortical structures is maintained, while the cortical circuitry is altered.