Article
Public, Environmental & Occupational Health
J. W. Power, J. W. Ryan, B. Hutchinson, D. Brady, M. M. Hannan, K. J. O'Malley, B. D. Murphy, N. Scanlon, N. Soman, C. McGarvey, M. M. McNicholas, C. G. Cronin, J. G. Murray
Summary: TRUS biopsy of the prostate carries an increased risk of post-procedural sepsis. In response to the COVID-19 pandemic, the study institution reduced TRUS biopsy services and switched to transperineal biopsy to eliminate the risk of post-procedural sepsis and maintain a service for prostate cancer diagnosis.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Medicine, General & Internal
Ender Siyez
Summary: This study aimed to compare the incidence of febrile infectious complications after transrectal ultrasound-guided prostate biopsy in men receiving ciprofloxacin prophylaxis alone versus ciprofloxacin with povidone-iodine transrectal injection. The results showed a lower rate of febrile infectious complications in patients who received both ciprofloxacin and povidone-iodine prophylaxis compared to those who only received ciprofloxacin.
Review
Oncology
Jianfeng Xie, Chunchun Jin, Mengmeng Liu, Kun Sun, Zhanqiang Jin, Zhimin Ding, Xuehao Gong
Summary: Compared to traditional TRUS-guided biopsy, MRI-TB has a higher detection rate for clinically significant and high-risk PCa, but a lower detection rate for clinically insignificant PCa. MRI-TB combined with SB diagnoses more cases of overall, clinically significant, and high-risk PCa.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Michael S. Leapman, Cassandra L. Thiel, Ilyssa O. Gordon, Adam C. Nolte, Aaron Perecman, Stacy Loeb, Michael Overcash, Jodi D. Sherman
Summary: This study estimated the environmental impacts associated with prostate magnetic resonance imaging (MRI) and biopsy, and found that reducing unnecessary biopsies or using MRI as a decision-making tool can decrease healthcare pollution and greenhouse gas emissions.
Article
Urology & Nephrology
Cameron J. Parkin, Daniel Gilbourd, Richard Grills, Sue Chapman, Sydney Weinstein, Neil Joshi, Balasubramaniam Indrajit, Jonathan Kam, Teresa Smilovic, Andrew Shepherd, Njeri Gikenye, Mark W. Louie-Johnsun
Summary: Transrectal ultrasound-guided prostate needle biopsy remains a common method for diagnosing prostate cancer worldwide. This study in Australian centres found low rates of infective complications, with less than 1% of cases experiencing readmissions for infections. Further prospective studies comparing techniques are needed before considering abandoning TRUS in favor of trans-perineal approaches.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Medicine, General & Internal
Byeongdo Song, Sung Il Hwang, Hak Jong Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sangchul Lee
Summary: This study compared the complications and pathological outcomes between TRUS-PB and MRI-TRUS FTPB, and found that MRI-TRUS FTPB is as safe as TRUS-PB in terms of complications. Additionally, the study showed that prostate volume is an important predictor of complications after prostate biopsy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsin-Yu Chen, Robert A. Bok, Matthew R. Cooperberg, Hao G. Nguyen, Katsuto Shinohara, Antonio C. Westphalen, Zhen J. Wang, Michael A. Ohliger, Daniel Gebrezgiabhier, Lucas Carvajal, Jeremy W. Gordon, Peder E. Z. Larson, Rahul Aggarwal, John Kurhanewicz, Daniel B. Vigneron
Summary: This study demonstrated the safety and feasibility of integrating hyperpolarized C-13 MR biomarkers into the standard mpMRI workflow to guide MR-transrectal ultrasound fusion biopsies. The study included 5 men on active surveillance undergoing integrated scan and subsequent biopsies, showing promising results with no adverse events reported.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Mengxing Wei, Lulu Wang, Yanfang Wang, Tong Zhang, Chenchen Wang, Chengfan Wu, Changlin Tian, Gaolin Liang, Yue Yuan
Summary: Magnetic resonance imaging (MRI) is an excellent imaging technique with unlimited tissue penetration depth and superb spatiotemporal resolution. However, the use of intracellular self-assembled Gd-containing nanoparticles to enhance T-2-weighted MR contrast in vivo for precise tumor MRI is rarely reported. This study developed a CTSB-responsive small molecular contrast agent VC-Gd-CBT, which can self-assemble into large intracellular Gd-containing nanoparticles, and it has the potential to be used as a T-2 contrast agent for early-stage cancer diagnosis.
Article
Urology & Nephrology
Dylan Buller, Jessa Sahl, Ilene Staff, Joseph Tortora, Kevin Pinto, Tara Mclaughlin, Laura Olivo Valentin, Joseph Wagner
Summary: This study assessed the rates of clinically relevant prostate cancer detection and complications associated with transperineal and transrectal biopsies guided by magnetic resonance imaging (MRI). The results showed no significant differences in the detection rates of clinically relevant prostate cancer and complication rates between the two biopsy approaches, regardless of prior biopsy status or active surveillance.
Article
Urology & Nephrology
Xue-fei Ding, Yang Luan, Sheng-ming Lu, Guang-chen Zhou, Tian-bao Huang, Liang-yong Zhu, Cheng-hao Guo
Summary: The study found that patients with diabetes and a history of urinary retention were more likely to experience infection complications after transperineal prostate biopsy.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Multidisciplinary Sciences
Nils Kohn, Jan Heidkamp, Guillen Fernandez, Jurgen Futterer, Indira Tendolkar
Summary: Patients suspected of cancer who undergo MRI guided prostate biopsy experience acute stress responses, with changes in affect impacting positive and negative emotions. Factors associated with stress levels include cortisol levels, depression scores, and brain connectivity.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Artificial Intelligence
Sulaiman Vesal, Iani Gayo, Indrani Bhattacharya, Shyam Natarajan, Leonard S. Marks, Dean C. Barratt, Richard E. Fan, Yipeng Hu, Geoffrey A. Sonn, Mirabela Rusu
Summary: This study introduces a novel 2.5D deep neural network for prostate segmentation on ultrasound images, addressing the challenges of reduced signal-to-noise ratio and artifacts. By combining supervised domain adaptation technique and knowledge distillation loss, the performance drop after model finetuning on new datasets is reduced. The approach achieves high segmentation accuracy and generalizes well in multi-center studies, demonstrating its potential for clinical application.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Urology & Nephrology
Xiao Wang, Yanqi Xie, Xiangyi Zheng, Ben Liu, Hong Chen, Jiangfeng Li, Xueyou Ma, Jianjian Xiang, Guobin Weng, Weizhi Zhu, Gang Wang, Ye Fang, Hongtao Cheng, Liping Xie
Summary: This study aims to compare the detection rates of prostate cancer (PCa) using AIUSP, TRUS-SB, and mpMRI, and finds that AIUSP has the highest detection rate, suggesting it could be an alternative to systematic biopsy in the future.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Ruud J. G. van Sloun, Rogier R. Wildeboer, Christophe K. Mannaerts, Arnoud W. Postema, Maudy Gayet, Harrie P. Beerlage, Georg Salomon, Hessel Wijkstra, Massimo Mischi
Summary: This study utilized deep learning to achieve automatic, real-time prostate segmentation on TRUS images, demonstrating high accuracy and robust performance on different ultrasound scanners. The algorithm showed strong correlation between its self-assessment of segmentation performance and actual performance, enabling swift identification of potential errors.
EUROPEAN UROLOGY FOCUS
(2021)
Review
Oncology
Bhavan Prasad Rai, Christoph Mayerhofer, Bhaskar Kumar Somani, Panagiotis Kallidonis, Udo Nagele, Theodoros Tokas
Summary: This study compared the outcomes of MRI-guided and transrectal ultrasound fusion transrectal biopsy (TRUSB) with MRI-guided and transrectal ultrasound fusion transperineal biopsy (TPB). The analysis suggests that TPB has better detection for clinically significant prostate cancer, anterior tumors, and lower complications, although the evidence certainty is low.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Article
Oncology
Christopher U. Jones, Stephanie L. Pugh, Howard M. Sandler, Michael P. Chetner, Mahul B. Amin, Deborah W. Bruner, Anthony L. Zietman, Robert B. Den, Mark H. Leibenhaut, John M. Longo, Jean-Paul Bahary, Seth A. Rosenthal, Luis Souhami, Jeff M. Michalski, Alan C. Hartford, Pradip P. Amin, Mack Roach, Don Yee, Jason A. Efstathiou, Joseph P. Rodgers, Felix Y. Feng, William U. Shipley
Summary: The study shows that adding short-term androgen deprivation therapy (ADT) to radiation therapy (RT) improves overall survival and reduces disease-specific mortality, biochemical failure, local progression, and distant metastases in men with localized prostate cancer.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Review
Oncology
Ursula M. Vogl, Tomasz M. Beer, Ian D. Davis, Neal D. Shore, Christopher J. Sweeney, Piet Ost, Gerhardt Attard, Alberto Bossi, Johann de Bono, Charles G. Drake, Eleni Efstathiou, Stefano Fanti, Karim Fizazi, Susan Halabi, Nicolas James, Nicolas Mottet, Anwar R. Padhani, Mack Roach, Mark Rubin, Oliver Sartor, Eric Small, Matthew R. Smith, Howard Soule, Matthew R. Sydes, Bertrand Tombal, Aurelius Omlin, Silke Gillessen
Summary: This article discusses the lack of consensus on clinical management issues in advanced prostate cancer addressed at the Advanced Prostate Cancer Consensus Conference. By reviewing ongoing clinical trials, it is found that many unresolved questions remain. The article emphasizes that the lack of consensus indicates gaps in existing evidence and calls for robust clinical trials to fill these gaps.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Juanita Crook, Joseph P. Rodgers, Thomas M. Pisansky, Edouard J. Trabulsi, Mahul B. Amin, William Bice, Gerard Morton, Albert D. Murtha, Eric Vigneault, Joelle Helou, Jeff M. Michalski, Mack Roach, David Beyer, Ashesh B. Jani, Eric M. Horwitz, Adam Raben, Stephanie Pugh, Howard Sandler
Summary: This is the first prospective multicenter trial reporting outcomes of salvage low-dose-rate prostate brachytherapy for local failure after external beam radiation therapy. The 5-year freedom from biochemical failure rate is 68%, comparable to other salvage modalities. Although further local failure is rare (5%), biochemical failure rate climbs to 46% by 10 years.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Editorial Material
Immunology
Mack Roach, Robert A. Hiatt, Steven Black
JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Oncology
Mack Roach
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Urology & Nephrology
Angelo J. Cambio, Richard M. Roach, Paul Arnold, Joseph Cambio, Clifford D. Gluck, Sean P. Heron
Summary: This study demonstrates that catheter-dependent men with sufficient bladder contractility can achieve volitional voiding and successful bladder drainage using The Spanner Temporary Prostatic Stent for extended periods of time.
ADVANCES IN UROLOGY
(2022)
Article
Oncology
Ting Martin Ma, Yilun Sun, Shawn Malone, Mack Roach III, David Dearnaley, Thomas M. Pisansky, Felix Y. Feng, Howard M. Sandler, Jason A. Efstathiou, Isabel Syndikus, Emma C. Hall, Alison C. Tree, Matthew R. Sydes, Claire Cruickshank, Soumyajit Roy, Michel Bolla, Philippe Maingon, Theo De Reijke, Abdenour Nabid, Nathalie Carrier, Luis Souhami, Almudena Zapatero, Araceli Guerrero, Ana Alvarez, Carmen Gonzalez San-Segundo, Xavier Maldonado, Tahmineh Romero, Michael L. Steinberg, Luca F. Valle, Matthew B. Rettig, Nicholas G. Nickols, Jonathan E. Shoag, Robert E. Reiter, Nicholas G. Zaorsky, Angela Y. Jia, Jorge A. Garcia, Daniel E. Spratt, Amar U. Kishan
Summary: The sequencing of androgen-deprivation therapy (ADT) and radiotherapy (RT) may affect the outcome of prostate cancer depending on the size of the RT field. A study found that the sequencing of ADT has a significant impact on clinical outcomes for men receiving ADT with prostate-only RT (PORT) or whole-pelvis RT (WPRT).
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Andrew M. McDonald, Lyudmila DeMora, Eddy S. Yang, John M. Hoyle, Andrew Lenzie, Grant R. Williams, Jeff M. Michalski, Don Yee, Jean-Paul Bahary, Robert B. Den, Mack Roach, Robert Dess, Mark Mishra, Richard K. Valicenti, Harold Y. Lau, Samuel R. Marcrom, Luis Souhami, Lucas C. Mendez, Yuhchyau Chen, Desiree E. Doncals, Stephanie L. Pugh, Felix Y. Feng, Howard M. Sandler
Summary: The purpose of this study was to validate the association between body composition and mortality in men treated with radiation for localized prostate cancer (PCa), and to classify patients by risk of all-cause mortality using body composition as a factor. The results showed a strong relationship between body composition and mortality in men with localized PCa, especially among older patients. Further research is needed to determine the clinical impact of body composition on prognostic models in men with PCa.
Article
Oncology
Himanshu R. Lukka, Snehal Deshmukh, Deborah W. Bruner, Jean-Paul Bahary, Colleen A. F. Lawton, Jason A. Efstathiou, Rajat J. Kudchadker, Lee E. Ponsky, Samantha A. Seaward, Ian S. Dayes, Darindra D. Gopaul, Jeff M. Michalski, Guila Delouya, Irving D. Kaplan, Eric M. Horwitz, Mack Roach, Felix Y. Feng, Stephanie L. Pugh, Howard M. Sandler, Lisa A. Kachnic
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Paul L. Nguyen, Huei-Chung (Rebecca) Huang, Daniel E. Spratt, Elai Davicioni, Howard M. Sandler, William U. Shipley, Jason A. Efstathiou, Jeffry P. Simko, Alan Pollack, Adam P. Dicker, Mack Roach III, Seth A. Rosenthal, Kenneth L. Zeitzer, Lucas C. Mendez, Alan C. Hartford, William A. Hall, Anand B. Desai, Rachel A. Rabinovitch, Christopher A. Peters, Joseph P. Rodgers, Phuoc Tran, Felix Y. Feng
Summary: The study validates the performance of Decipher genomic classifier (GC) in pretreatment biopsy samples. The GC score is independently associated with distant metastases, prostate cancer-specific mortality, and overall survival, providing valuable prognostic information for personalized decision-making.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Editorial Material
Oncology
Mack Roach III, Pamela W. Coleman, Rachel A. Sabol
PRACTICAL RADIATION ONCOLOGY
(2023)
Editorial Material
Oncology
Mack Roach III, Pamela W. Coleman
JCO ONCOLOGY PRACTICE
(2023)
Article
Oncology
Jeff M. Michalski, Kathryn A. Winter, Bradley R. Prestidge, Martin G. Sanda, Mahul Amin, William S. Bice, Hiram A. Gay, Geoffrey S. Ibbott, Juanita M. Crook, Charles N. Catton, Adam Raben, Walter Bosch, David C. Beyer, Steven J. Frank, Michael A. Papagikos, Seth A. Rosenthal, H. Joseph Barthold, Mack Roach, Jennifer Moughan, Howard M. Sandler
Summary: The purpose of this study was to determine whether the addition of external beam radiation therapy (EBRT) to brachytherapy (BT) (COMBO) would improve 5-year freedom from progression (FFP) in intermediate-risk prostate cancer. The results showed that COMBO did not improve FFP compared to BT and caused greater toxicity. Therefore, BT can be considered as a standard treatment for men with intermediate-risk prostate cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Correction
Health Care Sciences & Services
Andre J. Esteva, Jean Feng, Douwe van der Wal, Shih-Cheng Huang, Jeffry Simko, Sandy E. DeVries, Emmalyn Chen, Edward Schaeffer, Todd Morgan, Yilun Sun, Amirata A. Ghorbani, Nikhil Naik, Dhruv G. Nathawani, Richard D. Socher, Jeff L. Michalski, Mack R. Roach III, Thomas G. Pisansky, Jedidiah Monson, Farah A. Naz, James Wallace, Michelle M. Ferguson, Jean-Paul T. Bahary, James E. Zou, Matthew Lungren, Serena Y. Yeung, Ashley Ross, Howard M. Sandler, Phouc T. Tran, Daniel E. Spratt, Stephanie Pugh, Felix Y. Feng, Osama Mohamad
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Edward M. Schaeffer, Sandy Srinivas, Nabil Adra, Yi An, Daniel Barocas, Rhonda Bitting, Alan Bryce, Brian Chapin, Heather H. Cheng, Anthony Victor D'Amico, Neil Desai, Tanya Dorff, James A. Eastham, Thomas A. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E. Ippolito, Michael R. Kuettel, Joshua M. Lang, Tamara Lotan, Rana R. McKay, Todd Morgan, George Netto, Julio M. Pow-Sang, Robert Reiter, Mack Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, Jonathan Tward, Richard Valicenti, Jessica Karen Wong, Ryan A. Berardi, Dorothy A. Shead, Deborah A. Freedman-Cass
Summary: The NCCN Guidelines for Prostate Cancer discuss staging and risk assessment after a prostate cancer diagnosis and provide treatment options for different stages of the disease. The guidelines are updated annually based on new clinical data and input from various sources. This article summarizes the discussions regarding systemic therapy for metastatic prostate cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)