Review
Radiology, Nuclear Medicine & Medical Imaging
Anjan Bhattarai, Gary F. Egan, Paul Talman, Phyllis Chua, Zhaolin Chen
Summary: This review provides an overview of MRI techniques used to investigate iron dysregulation in ALS, highlighting their potential uses and limitations in disease diagnosis and prognosis. It recommends further longitudinal studies to validate the efficacy of these techniques and concludes that quantitative iron assessment using QSM in MRI holds great potential as a sensitive diagnostic and prognostic marker in ALS. Furthermore, combining multimodal neuroimaging markers with iron imaging may offer improved sensitivity in ALS diagnosis and prognosis, contributing significantly to clinical care and treatment trials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe S. Furtado, Nathaniel D. Mercaldo, Thomas Vahle, Thomas Benkert, William R. Bradley, Lisa Ratanaprasatporn, Ravi Teja Seethamraju, Mukesh G. Harisinghani, Susanna Lee, Krista Suarez-Weiss, Lale Umutlu, Ciprian Catana, Kelsey L. Pomykala, Liran Domachevsky, Hanna Bernstine, David Groshar, Bruse R. Rosen, Onofrio Antonio Catalano
Summary: This study compared standard (STD-DWI) single-shot echo-planar imaging DWI and simultaneous multislice (SMS) DWI during whole-body positron emission tomography (PET)/MRI in terms of acquisition time, image quality, and lesion detection. The results showed that SMS-DWI shortened the acquisition time and maintained or improved the diagnostic yield in most anatomical regions. Therefore, SMS-DWI has important clinical application prospects in cancer staging and restaging.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takahiro Tsuboyama, Hiromitsu Onishi, Atsushi Nakamoto, Kazuya Ogawa, Yoshihiro Koyama, Hiroyuki Tarewaki, Noriyuki Tomiyama
Summary: This study evaluated the effects of deep learning reconstruction and a sharpening filter on the image quality of SSFSE T2-weighted imaging of the uterus. The results showed that the combination of DL and a sharpening filter significantly improved the image quality, reaching the level of the PROPELLER sequence.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Clinical Neurology
Helen Bachmann, Melissa Cambron, Jan W. Casselman, Veroniek Van Driessche, Eline Van Haute, Liesbeth Van Hijfte, Tim Kelderman, Dimitri Hemelsoet, Guy Laureys
Summary: In this study, the occurrence of occult hemorrhagic cerebral lesions after alemtuzumab treatment was investigated in RRMS patients, with no significant findings. There was no association found between alemtuzumab treatment and arterial hypertension, intracerebral hemorrhage, or occult microbleeds in the patient population studied.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Koy Chong Ng Kee Kwong, Daisy Mollison, Rozanna Meijboom, Elizabeth N. York, Agniete Kampaite, Sarah-Jane Martin, David P. J. Hunt, Michael J. Thrippleton, Siddharthan Chandran, Adam D. Waldman
Summary: Rim lesions, characterized by a paramagnetic rim on susceptibility-based MRI, were detected in 27% of early relapsing-remitting MS patients in this multicenter study. The difference in longitudinal volume change between rim lesions and non-rim lesions is still unclear at this stage. Further validation and standardization in defining rim lesions as a biomarker of chronic inflammation are needed for potential translation into routine MS clinical practice.
Article
Medicine, General & Internal
Masoud Rabbani, Vahid Shaygannejad, Mahshid Bahrami, Sajad Badiei
Summary: The study aimed to compare susceptibility-weighted imaging (SWI) with conventional MRI methods in multiple sclerosis (MS) plaque assessment, finding similar efficiency between SWI and conventional MRI sequences for plaque evaluation in MS patients. There was no significant difference in plaque number and volume between different imaging modalities, and a high correlation was observed between SWI and T2W/FLAIR conventional imaging techniques in estimating plaque characteristics.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: The study suggests that advanced diffusion-weighted imaging techniques can accurately detect white matter atrophy in patients with multiple sclerosis, providing more specific information than traditional methods that only measure volume and diffusion. Additionally, measures such as voxel-wise fiber-bundle cross-section and intra-cellular volume obtained at baseline are better predictors of clinical disability and cognitive impairment.
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Megan Co, Huiming Dong, Daniel J. Boulter, Xuan Nguyen, Safdar N. Khan, Brian Raterman, Brett Klamer, Arunark Kolipaka, Benjamin A. Walter
Summary: This study validated the use of a spin-echo echo-planar imaging (SE-EPI) sequence for magnetic resonance elastography (MRE) of the intervertebral disc (IVD). The results showed that the SE-EPI sequence can effectively assess the shear properties of the IVD, with good correlation to the standard gradient recalled echo (GRE) sequence, and it also reduces scan times.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neuroimaging
Sagar Buch, Karthikeyan Subramanian, Pavan K. Jella, Yongsheng Chen, Zhen Wu, Kamran Shah, Evanthia Bernitsas, Yulin Ge, E. Mark Haacke
Summary: The study using Ferumoxytol contrast agent revealed vascular abnormalities in MS patients and obtained small vessel densities, providing new insights into the pathophysiology of the disease.
NEUROIMAGE-CLINICAL
(2021)
Article
Physiology
Feifei Gao, Zejun Wen, Shewei Dou, Xiaojing Kan, Shufang Wei, Yinghui Ge
Summary: The use of simultaneous multi-slice TSE (SMS-TSE) sequence can significantly reduce scanning time in the wrist, ankle, and knee joints while maintaining similar image quality compared to the routine TSE sequence.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Clinical Neurology
E. Mark Haacke, Yulin Ge, Sean K. Sethi, Sagar Buch, Paolo Zamboni
Summary: The etiology of multiple sclerosis is believed to be autoimmune, but evidence suggests disrupted vasculature and flow play a significant role. Abnormal flow in the medullary vein system is implicated, with history dating back to the nineteenth century. Vascular effects in MS lesions involve endothelial damage, venous collagenosis, and ultimately lead to inflammatory and demyelinating events.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Qing Fu, Xiang-chuang Kong, Ding-Xi Liu, Kun Zhou, Yi-hao Guo, Zi-Qiao Lei, Chuan-sheng Zheng, Fan Yang
Summary: TGSE-PROPELLER-DWI demonstrated superior image quality and diagnostic performance compared to rs-EPI in evaluating orbital tumors, with significantly improved geometric distortion and susceptibility artifacts. The ADC(lesion) of TGSE-PROPELLER-DWI was higher than rs-EPI, and the two methods showed comparable diagnostic performance in differentiating malignant and benign orbital tumors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rezvan Afkandeh, Maziar Irannejad, Iraj Abedi, Masoud Rabbani
Summary: This study proposes a Bayesian approach to automatically detect active and inactive multiple sclerosis (MS) plaques in SWI images. The results show that the method has a high accuracy rate of 91% and a sensitivity rate of 76% in identifying plaque types and areas. The analysis reveals an 80% agreement between expert diagnoses and Bayesian inferences.
Article
Clinical Neurology
Masaaki Yasui, Jinsoo Koh, Yoshiaki Nakayama, Mayumi Sakata, Yasuhiro Hiwatani, Hiroshi Ishiguchi, Hidefumi Ito
Summary: The MCLI score can serve as a diagnostic marker for ALS, as it is correlated with the UMN and Delta FRS scores.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Margareta A. Clarke, Rachael Cheek, Habeeb F. Kazimuddin, Bryan Hernandez, Reece Clarke, Colin D. Mcknight, Joy Derwenskus, James Eaton, Rebecca Irlmeier, Fei Ye, Kristin P. O'Grady, Baxter Rogers, Seth A. Smith, Francesca Bagnato
Summary: In this study, we used 7 tesla magnetic resonance imaging to investigate the imaging markers of multiple sclerosis lesions. We found that paramagnetic rim lesions were associated with larger lesion size and lower myelin integrity, while the central vein sign was not associated with these indicators.
JOURNAL OF NEUROIMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhuozhi Dai, Sanjay Kalra, Dennell Mah, Peter Seres, Hongfu Sun, Renhua Wu, Alan H. Wilman
Summary: This study compared amide concentration changes in ALS patients and healthy controls using multimodal magnetic resonance imaging, and found significantly reduced amide signal intensities in the motor cortex and corticospinal tract of ALS patients with no significant correlation with clinical scores. The diagnostic accuracy of the amide peak was superior to diffusion imaging.
EUROPEAN RADIOLOGY
(2021)
Article
Biophysics
Yang Gao, Xuanyu Zhu, Bradford A. Moffat, Rebecca Glarin, Alan H. Wilman, G. Bruce Pike, Stuart Crozier, Feng Liu, Hongfu Sun
Summary: The newly designed xQSM method, trained with in vivo datasets and incorporating noise regularization and modified convolutional layers into a U-net backbone, shows excellent reconstruction performance and generalization capability in the field of QSM. It achieved significant improvements in globus pallidus susceptibility estimation and substantially shortened the reconstruction time from minutes to seconds.
NMR IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas MacLennan, Peter Seres, Julia Rickard, Emily Stolz, Christian Beaulieu, Alan H. Wilman
Summary: In 3T MRI imaging, the variation of B1+ in the brain is mainly influenced by age and brain size, showing relatively small intersubject variability overall, with the least variability occurring in central regions while regions near the brain edges displayed marked increases in variation.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Sarah Treit, Julia N. Rickard, Emily Stolz, Kevin Solar, Peter Seres, Derek Emery, Christian Beaulieu
Summary: The goal of this study was to create a normative brain MRI database for comparisons with various neurological disorders across the lifespan. A sample of 378 neurotypical controls completed brain MRI and other assessments, providing valuable insight into healthy brain development and aging.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeff Snyder, Kelly C. McPhee, Alan H. Wilman
Summary: The study explores T-2 quantification in 3D FSE sequences to achieve increased resolution compared to established 2D methods. Through optimization of echo-train design, the 3D FSE sequence performs similarly to 2D methods while providing three-fold-higher slice resolution and better T-2 fitting. It is concluded that T-2 mapping using optimized 3D FSE sequences can offer high-resolution benefits and accuracy comparable to 2D methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nima Mehdizadeh, Alan H. Wilman
Summary: This study introduces a new method using a rapid B-1(+) mapping sequence to improve the calculation of myelin water fraction (MWF). Results show that utilizing an independent B-1(+) map can increase mean MWF and reduce the coefficient of variation.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Biophysics
Nashwan Naji, M. Louis Lauzon, Peter Seres, Emily Stolz, Richard Frayne, Catherine Lebel, Christian Beaulieu, Alan H. Wilman
Summary: This study investigates the reproducibility of QSM and R-2* at 3 T using locally optimized sequences from different centers and vendors. The results show that the measurements of the same subject's region of interest for QSM and R-2* at different sites are highly correlated and reproducible. The reproducibility is also good within the same site. Postprocessing approaches can help reduce cross-site variability.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Jeff Snyder, Peter Seres, Robert W. Stobbe, Justin G. Grenier, Penelope Smyth, Gregg Blevins, Alan H. Wilman
Summary: A fast T2 mapping reconstruction method is proposed and compared with a previous modeling approach. The results show that the new method significantly reduces computation time and enables real-time generation of T2 maps on the MRI console.
NMR IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashmita De, Hongfu Sun, Derek J. Emery, Kenneth S. Butcher, Alan H. Wilman
Summary: The purpose of this study was to optimize quantitative susceptibility-weighted imaging for strong susceptibility sources like hemorrhage and compare it to standard susceptibility-weighted imaging and quantitative susceptibility mapping. The results showed that quantitative susceptibility-weighted imaging minimized blooming effects and phase wrap artifacts observed in susceptibility-weighted imaging. However, it requires an altered upper threshold for best hemorrhage depiction.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Nabeela Nathoo, Myrlene Gee, Krista Nelles, Jacqueline Burt, Hongfu Sun, Peter Seres, Alan H. Wilman, Christian Beaulieu, Fang Ba, Richard Camicioli
Summary: This study found that susceptibilities in basal ganglia and extra-basal ganglia structures are related to qualitative measures of gait impairment and freezing of gait in Parkinson's disease.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jinming Qiu, Guanru Tan, Yan Lin, Jitian Guan, Zhuozhi Dai, Fei Wang, Caiyu Zhuang, Alan H. Wilman, Huaidong Huang, Zhen Cao, Yanyan Tang, Yanlong Jia, Yan Li, Teng Zhou, Renhua Wu
Summary: The study evaluated the feasibility of using deep learning to automatically detect intracranial arterial steno-occlusive lesions and developed a deep learning algorithm based on the YOLOv5 model. The algorithm showed a sensitivity of 64.2% and a positive predictive value of 83.7% for detecting lesions, with the highest detection sensitivity in the internal carotid artery.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Biophysics
Jeff Snyder, Peter Seres, Alan H. Wilman
Summary: Three-dimensional fast spin echo imaging with long echo trains combines high resolution with reasonable acquisition times, reduced specific absorption rate, and low refocusing flip angles. The inclusion of selective pulse and spoiler gradients results in a signal-to-noise ratio (SNR) penalty for slab select excitation, and the SNR decreases further due to B1(+) variation and T2/T1 times. Therefore, choosing slab-selective excitation should consider the required SNR, chosen anatomy, and sequence restrictions.
NMR IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Seyed Amir Ali Adel, Sarah Treit, Wasan Abd Wahab, Graham Little, Laura Schmitt, Alan H. Wilman, Christian Beaulieu, Donald W. Gross
Summary: This study found stable volume, MD, and T2 changes in sclerotic hippocampi of TLE patients over time, with good sensitivity and specificity in detecting subfield neuron loss on postsurgical histology using MD and T2 maps. Therefore, high-resolution hippocampal DTI and T2 may have the potential to diagnose HS subtype before surgery.
Article
Biophysics
Diana Valdes Cabrera, Gregg Blevins, Penelope Smyth, Derek Emery, Kevin Grant Solar, Christian Beaulieu
Summary: High-resolution DTI and T2 mapping revealed abnormalities in the hippocampus of patients with multiple sclerosis. In patients with cognitive impairment, higher MD and T2 values and lower FA and volume were observed. These abnormalities may be associated with demyelination, neuron loss, and/or inflammation.
NMR IN BIOMEDICINE
(2023)
