Article
Multidisciplinary Sciences
Cajetan Immanuel Lang, Praveen Vasudevan, Piet Doering, Ralf Gaebel, Heiko Lemcke, Tobias Lindner, Gustav Steinhoff, Bernd Joachim Krause, Brigitte Vollmar, Felix G. Meinel, Seyrani Yuecel, Alper Oener, Hueseyin Ince, Robert David
Summary: This study investigated post-infarct remodeling after acute myocardial infarction using mouse models and magnetic resonance imaging. The results showed differences in cardiac remodeling between the permanent ligation (PL) and ischemia reperfusion (I/R) models. Different methods of analysis revealed that PL resulted in significant left ventricle dilation and decreased contractile function, while the effects were less pronounced in the I/R model.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Medicine, General & Internal
Jane A. Leopold, Darren B. Taichman
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, the mortality rate after coronary-artery revascularization procedures is around 50%. Mechanical circulatory support, such as extracorporeal life support with venoarterial extracorporeal membrane oxygenation, can improve perfusion and workload for patients with persistent hemodynamic compromise and organ hypoperfusion.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xavier Dieu, Floris Chabrun, Fabrice Prunier, Denis Angoulvant, Nathan Mewton, Francois Roubille, Pascal Reynier, Marc Ferre, Valerie Moal, Laurane Cottin, Alain Furber, Gabriel Garcia, Loic Biere, Delphine Mirebeau-Prunier
Summary: Machine learning approach improves the risk prediction of 3-month left ventricular remodeling occurrence after myocardial infarction. Compared to traditional methods, machine learning shows higher sensitivity in predicting post-MI left ventricular remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Masashi Tomimatsu, Kotaro Matsumoto, Moe Ashizuka, Shohei Kumagai, Shota Tanaka, Takafumi Nakae, Kosei Yokota, Shunsuke Kominami, Ryota Kajiura, Daisuke Okuzaki, Daisuke Motooka, Aki Shiraishi, Takaya Abe, Hideo Matsuda, Yoshiaki Okada, Makiko Maeda, Shigeto Seno, Masanori Obana, Yasushi Fujio
Summary: Runx2 plays an important role in cardiac remodeling after myocardial infarction, with its deficiency leading to cardiac dysfunction and exacerbated fibrosis, possibly through regulating endothelial cell function.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Ke Shi, Hua-yan Xu, Yong He, Min Ma, Lu Zhang, Jun-long Wang, Xue-sheng Li, Chuan Fu, Hong Li, Bin Zhou, Xiao-yue Zhou, Zhi Yang, Ying-kun Guo, Zhi-gang Yang
Summary: This study aimed to assess inflammation in the remote myocardium post-myocardial infarction (MI) and its association with left ventricular (LV) remodeling using T2 mapping. The results found significant increases in remote T2 post-MI, indicating potential inflammatory response and pathological changes. Both animal and human experiments demonstrated remote myocardial alterations in T2, with variations in remote T2 independently associated with LV remodeling in patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Natalie N. N. Khalil, Megan L. L. McCain
Summary: Myocardial infarctions are a common form of cardiac injury and death globally, with the reparative process ultimately leading to scar tissue formation and heart failure. Traditional approaches to studying post-infarct cellular microenvironments have limited control over relevant features, while Organ on a Chip models have emerged as new paradigms for dissecting this complex environment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-xi Yang, Yong He, Min Ma, Qin Zhao, Hua-yan Xu, Chun-chao Xia, Wan-lin Peng, Zhen-lin Li, Hong Li, Ying-kun Guo, Zhi-gang Yang
Summary: ECVAI is associated with LV remodeling in all patients while native T1(AI) may be feasible when MVO is absent.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Article
Cardiac & Cardiovascular Systems
Pasquale Paolisso, Alberto Foa, Luca Bergamaschi, Francesco Donati, Michele Fabrizio, Chiara Chiti, Francesco Angeli, Sebastiano Toniolo, Andrea Stefanizzi, Matteo Armillotta, Paola Rucci, Gianmarco Iannopollo, Gianni Casella, Cinzia Marrozzini, Nazzareno Galie, Carmine Pizzi
Summary: The study confirmed the association of hyperglycemic obs-AMI with elevated inflammatory markers and larger infarct sizes. MINOCA patients showed modest myocardial damage, regardless of admission glucose levels.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Holger Thiele, Uwe Zeymer, Ibrahim Akin, Michael Behnes, Tienush Rassaf, Amir Abbas Mahabadi, Ralf Lehmann, Ingo Eitel, Tobias Graf, Tim Seidler, Andreas Schuster, Carsten Skurk, Daniel Duerschmied, Peter Clemmensen, Marcus Hennersdorf, Stephan Fichtlscherer, Ingo Voigt, Melchior Seyfarth, Stefan John, Sebastian Ewen, Axel Linke, Eike Tigges, Peter Nordbeck, Leonhard Bruch, Christian Jung, Jutta Franz, Philipp Lauten, Tomaz Goslar, Hans-Josef Feistritzer, Janine Poess, Eva Kirchhof, Taoufik Ouarrak, Steffen Schneider, Steffen Desch, Anne Freund, ECLS-SHOCK Investigators
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, early extracorporeal life support (ECLS) combined with standard medical treatment did not reduce mortality.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yinong Wang, Wufan Chen, Qing Wang
Summary: This study aims to develop a method for quantitatively analyzing segmental and transmural myocardial motion in MI rats. The results showed that this method successfully evaluated the reductions in systolic myocardial contractility induced by MI as well as the recovery induced by reperfusion. Therefore, this ultrasound-based quantitative estimation framework has great potential for non-invasive, novel, and early MI detection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David Schumacher, Adelina Curaj, Mareike Staudt, Franziska Cordes, Andreea R. Dumitrascu, Benjamin Rolles, Christian Beckers, Josefin Soppert, Mihaela Rusu, Sakine Simsekyilmaz, Kinan Kneizeh, Chrishan J. A. Ramachandra, Derek J. Hausenloy, Elisa A. Liehn
Summary: Phosphatidylserine has shown significant cardiomyocyte protection and improvement in heart function in both acute and chronic mouse models of myocardial infarction. The main mechanism of action seems to be through up-regulation of protein kinase C-epsilon. Additionally, pre-treatment with phosphatidylserine before AMI induction selectively inhibits neutrophil activation without affecting healing and fibrosis, suggesting a potential novel strategy for reducing infarct size and preventing myocardial injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
He Zhang, Zhaoxin Tian, Huaibi Huo, Han Li, Hui Liu, Yang Hou, Xu Dai, Ting Liu, Shiqi Jin
Summary: The location of myocardial infarction does not significantly affect the morphology and function of the left atrium, while patients with MI size greater than 15% are more likely to experience post-infarction left atrial remodeling and dysfunction than patients with MI size smaller than or equal to 15%.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Itai Rotem, Tal Konfino, Tal Caller, Yeshai Schary, Olga Shaihov-Teper, Dahlia Palevski, Nir Lewis, Daria Lendengolts, Nili Naftali-Shani, Jonathan Leor
Summary: Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. Recombinant osteopontin (OPN) has been found to play a significant role in myocardial healing by stimulating cardiac cell growth, cell-cycle re-entry, and migration. OPN also promotes proliferation and migration of non-cardiomyocytes. In animal models, OPN injection improves scar formation, cardiac function, and left ventricular remodeling. OPN may serve as a promising cell-free therapy for optimizing infarct repair.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Robert D. Hume, Shaan Kanagalingam, Tejas Deshmukh, Siqi Chen, Suzanne M. Mithieux, Fairooj N. Rashid, Iman Roohani, Juntang Lu, Tram Doan, Dinny Graham, Zoe E. Clayton, Eugene Slaughter, Eddy Kizana, April S. Stempien-Otero, Paula Brown, Liza Thomas, Anthony S. Weiss, James J. H. Chong
Summary: This study demonstrated that tropoelastin can improve post-MI healing by enhancing cardiac repair and reducing scar formation. Tropoelastin injection significantly improved left ventricular function, reduced scar size, and increased scar elastin content. Furthermore, it promoted elastic fiber formation and reduced immune response. The findings suggest potential therapeutic strategies for manipulating scar synthesis after MI.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yi Kei Tse, Hang Long Li, Si Yeung Yu, Mei Zhen Wu, Qing Wen Ren, Jiayi Huang, Hung Fat Tse, Jeroen J. Bax, Kai Hang Yiu
Summary: This study examines the predictors, changes, and prognostic implications of right ventricular (RV) remodelling in patients undergoing double-valve surgery. The study found that RV remodelling is strongly related to adverse outcomes and should be considered in risk assessment and decision-making for double-valve surgery.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Endocrinology & Metabolism
Mei-zhen Wu, Tiew-Hwa Katherine Teng, Wan-Ting Tay, Qing-wen Ren, Jasper Tromp, Wouter Ouwerkerk, Chanchal Chandramouli, Jia-Yi Huang, Yap-Hang Chan, Kanako Teramoto, Si-Yeung Yu, Claire Lawson, Hang-Long Li, Yi-Kei Tse, Xin-li Li, Denise Hung, Hung-Fat Tse, Carolyn S. P. Lam, Kai-Hang Yiu
Summary: Cardiorenal complications are common in patients with new-onset type 2 diabetes and are associated with a higher risk of mortality. Close surveillance of these complications is crucial to reduce the burden of disease.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Raymond Hang-Wun Li, Michele Mae-Ann Yuen, Carol Ho-Yi Fong, Ambrose Pak-Wah Leung, Justin Chiu-Man Chu, Loey Lung-Yi Mak, Tai-Hing Lam, Jean Woo, Yu-Cho Woo, Aimin Xu, Hung-Fat Tse, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Man-Fung Yuen, Karen Siu-Ling Lam
Summary: This study investigated whether incorporating additional metabolic risk factors improved liver fibrosis risk stratification in non-diabetic overweight/obese MAFLD individuals. The results showed that abnormal AST and HOMA-IR levels were independently associated with higher liver fibrosis risk, and a sequential screening algorithm using these factors was developed for risk identification.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin Y. F. So, Chun Ka Wong, Gordon Chun Kau Chan, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: Hypernatraemia is common in COVID-19 patients, especially during the Omicron era. Patients with hypernatraemia have higher 30-day mortality and longer hospital stays. This study provides insights into the epidemiology and clinical outcomes of hypernatraemia in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Gordon Chun Kau Chan, Chun Ka Wong, Benjamin Y. F. So, Jack Kit Chung Ng, Grace Chung Yan Lui, Cheuk Chun Szeto, Ivan Fan Ngai Hung, Hung Fat Tse, Sydney C. W. Tang, Tak Mao Chan, Kai Ming Chow, Desmond Y. H. Yap
Summary: This study investigates the epidemiology and outcomes of COVID-19 patients with hyponatremia. The results show that hyponatremic patients have higher 30-day mortality, prolonged hospitalization, and increased ICU admissions. Hyponatremia may serve as a prognostic indicator for unfavorable outcomes in COVID-19.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Chun-Ka Wong, Tsun-Ho Lam, Song-Yan Liao, Yee-Man Lau, Hung-Fat Tse, Benjamin Y. F. So
Summary: Despite the success of immune checkpoint inhibitors (ICIs) in cancer treatment, the occurrence of immune-related adverse events (IRAEs) is a major concern. ICI-induced myocarditis is a severe form of IRAE, and understanding its pathogenesis and treatment is still limited. Mouse models have been developed to study ICI-induced myocarditis, but additional interventions are required to mimic the pathology in humans. This review focuses on the immunopathogenesis of ICI-induced myocarditis and its potential implications for treatment.
Article
Cardiac & Cardiovascular Systems
Calvin Ka-Lam Leung, Lok-Yee Lam, Kwan-Yu Li, Yundi Feng, Gaozhen Cao, Min Wu, Run Wang, Mei-Zhen Wu, Qing-Wen Ren, Si-Yeung Yu, Yi-Kei Tse, Hang-Long Li, Shuk-Yin Yu, Hung-Fat Tse, Bo Xu, Kai-Hang Yiu
Summary: This study evaluated the prognostic value of computational pressure-flow dynamics-derived FFR in patients with stable coronary artery disease. The results showed that PCI was associated with a lower risk of adverse cardiovascular events in ischemic patients, but not in non-ischemic patients. Adherent-to-caFFR treatment was also associated with a lower risk of adverse events.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Xuxiao Ye, Caige Huang, Vincent Ka Chun Yan, Wei Kang, Min Fan, Gigi Kwan Chi Tsang, Clarissa Mung Yee Ho, Gregory Y. H. Lip, Kai-Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Eric Yuk Fai Wan, Xue Li, Cheuk Kwong Lee, Ivan Fan Ngai Hung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study aimed to evaluate the risk of ischaemic stroke or systemic embolism and bleeding following COVID-19 vaccination in patients with atrial fibrillation (AF), with a focus on sex differences. The results showed that there was an increased risk of ischaemic stroke or systemic embolism in female patients with AF after receiving the first dose of BNT162b2 or CoronaVac. However, the risk was even higher after COVID-19 infection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Marco Proietti, Tatjana Potpara, Moussa Mansour, Irina Savelieva, Hung Fat Tse, Andreas Goette, A. John Camm, Carina Blomstrom-Lundqvist, Dhiraj Gupta, Giuseppe Boriani
Summary: Stroke prevention in patients with atrial fibrillation has significantly improved with the introduction of non-vitamin K antagonist oral anticoagulants. Early rhythm control and cardiovascular risk factor management are also crucial in reducing the risk of stroke. Left atrial appendage occlusion or exclusion may be considered for patients who cannot undergo long-term oral anticoagulation. A holistic approach to atrial fibrillation management is recommended.
Article
Medicine, General & Internal
Eloi Marijon, Kumar Narayanan, Karen Smith, Sergio Barra, Cristina Basso, Marieke Blom, Lia Crotti, Andre D'Avila, Rajat Deo, Florence Dumas, Anastase Dzudie, Audrey Farrugia, Kaitlyn Greeley, Gerhard Hindricks, Wei Hua, Jodie Ingles, Taku Iwami, Juhani Junttila, Rudolph W. Koster, Jean-Benoit Le Polain De Waroux, Theresa M. Olasveengen, Marcus E. H. Ong, Michael Papadakis, Comilla Sasson, Sang Do Shin, Hung-Fat Tse, Zian Tseng, Christian Van Der Werf, Fredrik Folke, Christine M. Albert, Bo Gregers Winkel
Summary: Despite advancements in cardiovascular medicine, sudden cardiac death (SCD) remains a major challenge. Prevention efforts need to improve risk prediction and address arrhythmogenesis, while also strengthening community interventions and emergency medical systems. International collaboration and policy changes are crucial for further progress in tackling SCD.
Article
Cell & Tissue Engineering
Jingzhou Li, Fei Song, Ruolan Chen, Jinjuan Yang, Jie Liu, Li Huang, Fuyu Duan, Meng Kou, Boon Xuan Lian, Xiaoxia Zhou, Weimin Han, Liang Mao, Chan Wu, Weiyin Wu, Rui Wei, Hao Chen, Aimin Xu, Hung-Fat Tse, Qizhou Lian, Gang Li, Yan Wang
Summary: This study aimed to identify the active components of exosomes from bradykinin-pretreated cardiac-specific c-kit(+) cells and elucidate their underlying protective mechanisms in promoting angiogenesis against hindlimb ischemia.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Chi Ting Kwan, On Hang Samuel Ching, Pui Min Yap, Sau Yung Fung, Hok Shing Tang, Wan Wai Vivian Tse, Cheuk Nam Felix Kwan, Yin Hay Phoebe Chow, Nga Ching Yiu, Yung Pok Lee, Jessica Wing Ka Lau, Ambrose Ho Tung Fong, Qing-Wen Ren, Mei-Zhen Wu, Eric Yuk Fai Wan, Ka Chun Kevin Lee, Chun Yu Leung, Andrew Li, David Montero, Varut Vardhanabhuti, Jojo Siu Han Hai, Chung-Wah Siu, Hung-Fat Tse, Valentin Zingan, Xiaoxi Zhao, Haonan Wang, Dudley John Pennell, Raad Mohiaddin, Roxy Senior, Kai-Hang Yiu, Ming-Yen Ng
Summary: This study aimed to differentiate HFpEF patients from non-HFpEF patients and asymptomatic controls using intraventricular four-dimensional flow phase-contrast cardiovascular magnetic resonance. The results showed that CMR 4D flow derived LV direct flow and residual volume could effectively differentiate HFpEF patients from non-HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Correction
Cardiac & Cardiovascular Systems
Candela Diaz-Canestro, Hung-Fat Tse, Kai-Hang Yiu, David Montero
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Xuxiao Ye, Caige Huang, Yue Wei, Silvia T. H. Li, Vincent K. C. Yan, Kai -Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine S. L. Chui, Francisco T. T. Lai, Xue Li, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong, Esther W. Chan
Summary: This study aimed to investigate the safety of two COVID-19 vaccines, BNT162b2 and CoronaVac, in patients with heart failure (HF). The study found that there were no increased risks of hospitalization for HF, major adverse cardiovascular events (MACE), or all hospitalization after receiving these vaccines in patients with HF.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
X. Ye, E. S. Y. Chan, K. K. C. Man, C. K. Wong, H. F. Tse, E. W. Chan
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
