Article
Chemistry, Multidisciplinary
Yonggang Zhang, Jiaping Li, Vivian Hilda Maria Mouser, Nadia Roumans, Lorenzo Moroni, Pamela Habibovic
Summary: A biomimetic composite inspired by the composition and microstructure of natural bone was developed, showing excellent mechanical properties and bioactivity. It can serve as a load-bearing bone graft substitute and a 3D platform for studying cell-extracellular matrix interactions in bone tissue.
Article
Polymer Science
Sin Ting Ngo, Wei-Fang Lee, Yi-Fan Wu, Eisner Salamanca, Lwin Moe Aung, Yan-Qiao Chao, Ting-Chia Tsao, Hao-Wen Hseuh, Yi-Huan Lee, Ching-Chiung Wang, Wei-Jen Chang
Summary: Manufacturing 3D objects with polymers/bioceramic composite materials has been explored recently. This study focused on creating and assessing a solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (b-TCP) composite fiber as a scaffold material for 3D printing. Different ratios of b-TCP mixed with PCL were investigated to determine the optimal feedstock material for 3D printing. The addition of 20% b-TCP significantly improved the mechanical properties, biocompatibility, and osteogenic ability of the PCL/b-TCP mixture. These findings suggest that the solvent-free PCL-20 and PCL-30 fibers are promising materials for 3D printing customized bone scaffolds promptly, sustainably, and cost-effectively.
Article
Materials Science, Ceramics
C. Ruiz-Aguilar, U. Olivares-Pinto, I Alfonso
Summary: In this study, six different compositions of β-TCP scaffolds were produced using sodium chloride as a porogen at varying concentrations. The scaffolds showed promising physical, chemical, mechanical, and in vitro properties, with the formation of new crystalline phases and favorable bioactivity observed.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Pejman Ghaffari-Bohlouli, Hafez Jafari, Alireza Khatibi, Mamak Bakhtiari, Beeta Tavana, Payam Zahedi, Amin Shavandi
Summary: By reinforcing electrospun PLDLLA/PVA nanofibers with PCCNWs, the hydrophilicity, degradation rate, and mechanical properties of the composite material were enhanced, promoting cellular activity and showing potential for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Junge Wei, Rui Qu, Yanhe Wang, Lei Liu, Jie Yang, Huidi Xu, Xiaohong Hu, Xiaofeng Song
Summary: The study investigates the combination strategy of degradable SMP with drug release, showing that SMPs loaded with drugs have better shape recovery rate and drug release capability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Zihan Lu, Bowen Zhang, Hugh Gong, Jiashen Li
Summary: Two methods were developed to fabricate porous poly(L-lactide) (PLLA) fibres with good internal pore connection, including the removal of a pore-forming agent and non-solvent induced recrystallization. The results showed that the porous structures were successfully achieved in PLLA fibres with higher crystallization, leading to improved mechanical properties.
Article
Chemistry, Multidisciplinary
Rami Hador, Michael Shuster, Vincenzo Venditto, Moshe Kol
Summary: This study proposes a new approach to tolerate stereoerrors in the polymer by crowding them in a stereogradient copolymer. A zirconium complex of an amine tris(phenolate) ligand is used as a catalyst for the ring opening polymerization of meso-lactide at room temperature, and stereogradient copolymers are formed in the polymerization of mixtures of meso-lactide/L-lactide at 180 degrees C. These stereogradient copolymers exhibit enhanced crystallinities compared to stereorandom copolymers obtained with tin octanoate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: The study shows that the compatibility between PLLA and PLDLA-m decreases as the L-lactate unit content in PLDLA-m decreases, impacting the crystallization and compatibility of the blends.
Article
Biochemistry & Molecular Biology
Xiaohong Hu, Xiaofeng Song, Mengfei Xu, Yanhe Wang, Chuanming Zhu, Wanting Yu, Yuze Zhao
Summary: In this study, a shape memory composite was constructed by blending poly(epsilon-caprolactone) with TiO2 nanomaterial. The composite showed excellent shape fixing and recovery ratio, with a short recovery time at a low temperature. Moreover, the composite exhibited good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: By investigating the thermal properties, morphology, and thermal stability of PLLA/PDLA blends, a new stereoamorphous mesophase (sam-PLA) structure was discovered, and the relationship between different phases in the PLLA/PDLA blends was explored.
Article
Pharmacology & Pharmacy
Noha H. Radwan, Maha Nasr, Rania A. H. Ishak, Gehanne A. S. Awad
Summary: This study successfully synthesized composite scaffolds with different CaP phases, demonstrating good sustained release of MOX and adequate porosity. Cell viability tests showed that the selected composite scaffold maintained cellular proliferation and differentiation, while also reducing bacterial load and inflammation in bones.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Manjushree M. Bahir, Archana Rajendran, Deepak Pattanayak, Nibedita Lenka
Summary: This study successfully fabricated 3D composite scaffolds mimicking the ECM of bone tissue using collagen type I and calcium phosphate nanomaterials. The scaffolds exhibited similar microstructure, surface area, porosity, and mechanical strength as trabecular bone, and influenced the bioactivity, biocompatibility, and osteogenic differentiation potential of gingival-derived mesenchymal stem cells. Among the three types of scaffolds, BCP/Col-I showed the highest surface area and porosity, and promoted the maximum osteogenic differentiation of gMSCs. Additionally, the release of low concentrations of Ca2+ ions from the scaffolds also facilitated the osteogenic differentiation of mesenchymal stem cells.
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Engineering, Biomedical
Si-Yao Zheng, Zhi-Wei Liu, Hong-Lei Kang, Fan Liu, Guo-Ping Yan, Feng Li
Summary: Three-dimensional (3D)-printed scaffolds made of biodegradable polymers have been found to be effective in bone repair and regeneration, with low cytotoxicity, good biocompatibility, and the ability to enhance osteoblast proliferation.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biochemistry & Molecular Biology
Fen Ma, Chenguang Jiang, Wenyuan Xie, Defeng Wu
Summary: Using polysaccharide nanocrystals, such as chitin nanocrystals, as nanofillers for biodegradable aliphatic polymers is an attractive method for developing fully degradable nanocomposites. The incorporation of chitin nanocrystals in poly(L-lactide)/poly(D-lactide) blends promotes the formation of stereocomplex crystallites and accelerates overall crystallization kinetics. The nanocomposites exhibit higher stereocomplex crystallization temperatures and lower activation energy compared to the blend. However, the presence of chitin nanocrystals reduces the fraction of stereocomplex crystallites due to the nucleation effect, despite an increased rate of homocrystallization. This study provides valuable information for the use of chitin nanocrystals as nucleators for polylactide stereocomplexes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
