Investigation of Poly(styrene-alt-maleic anhydride) Copolymer for Controlled Drug Delivery of Ceftriaxone Antibiotic

Delivery of drugs by new technologies is a highly topical challenge of polymer chemistry. This report describes the preparation of antibacterial activated poly(styrene-alt-maleic anhydride) (PSMA) in which ceftriaxone antibiotic is covalently bonded onto the polymeric framework. The chemical grafting reaction of ceftriaxone antibiotic on PSMA was carried out in various ratios. In addition, PSMA was modified by isopropyle amine for preparation of PSMA-Isopropyle amide (PSMA-IPA) pH sensitive hydrogel. The physical loading of ceftriaxone antibiotic on PSMA-IPA in various ratios was carried out. The prepared copolymers were purified and their structures characterized by FT-IR and 1H-NMR spectroscopy. In vitro drug releasing was performed under specific conditions to investigate the influence of pH on the releasing rate.