☆ 4.3 Article

Benzo[h]quinoline based Macrocyclic Copper(II), Cobalt(II) Complexes: Synthesis, Characterization and Light induced DNA Cleavage Studies

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY (2009)

Journal

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY

Volume 46, Issue 8, Pages 790-795

Publisher

TAYLOR & FRANCIS INC

DOI: 10.1080/10601320903004558

Keywords

Benzo[h]quinoline-macrocycles; Co(II); Cu(II) complexes; photo-induced DNA cleavage

Categories

Polymer Science

Funding

Kuvempu University

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Abstract

A new ligand dibenzo[h]quinolineno[1,3,7,9] tetraazacyclododecine-7,15 (14H, 16H)-dibenzene (L) and its Co(II)/Cu(II) metal complexes of type [MLX2] (Where (M = Co(II) (5), Cu(II) (6) and X = Cl) were synthesized and are well characterized by FT-IR, 1H-NMR, FAB mass elemental analysis, and electronic spectral data. The role of the cobalt/copper metals in photo-induced DNA cleavage reactions was explored by designing complex molecules having macrocyclic structure. Finally, we have shown that photocleavage of plasmid DNA is more efficiently enhanced when this macrocyclic ligand is irradiated in the presence of copper(II) than that of cobalt metal.

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