Preparation and characterization of thermosensitive nanoparticles for targeted drug delivery

In this study, we have reported novel thermosensitive nanoparticles formulated by an emulsion-solvent evaporation technique using acetaminophen (AAP) as a model drug. The high entrapment efficiency of nanoparticles was 68.56%, particle size about 240.6 nm and zeta potential -27 mV. Furthermore, the drug release was also investigated both at 37 degrees C and 42 degrees C, respectively. The goal of our study was to obtain a targeted drug delivery system, exploiting the temperature-sensitive behavior. In contrary to normal temperature (37 degrees C), the release rate of AAP was found to noticeably increase at high temperature (42 degrees C) with a larger cumulative amount of drug released. In this way, it would lead to production of nanoparticles having a high thermosensitive behavior on drug release. Thus, this new strategy has the potential to control drug release at the diseased site for targeted drug delivery system (TDDS) with positive temperature-controlled.