Journal
JOURNAL OF LUMINESCENCE
Volume 205, Issue -, Pages 385-392Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jlumin.2018.09.054
Keywords
Photodynamic therapy; Cinnamic acid phthalocyanine; Magnetic nanoparticles; Singlet oxygen quantum yield
Categories
Funding
- African Laser Centre (ALC)
- Department of Science and Technology (DST)
- CSIR National Laser Centre
- Rental Pool Program
- National Research Foundation (NRF) of South Africa through DST/NRF South African Research Chairs Initiative for Professor of Medicinal Chemistry and Nanotechnology [UID 62620]
- Rhodes University
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This work reports on the synthesis, photophysico-chemical properties and photodynamic therapy activity of novel zinc (1) and indium (2) tetra substituted cinnamic acid phthalocyanine (Pc) complexes linked to amino functionalized magnetic nanoparticles (AMNPs) through an amide bond. Asymmetric ZnPc complex (3) showed better triplet and singlet oxygen quantum yields as compared to its symmetrical analogues (1 and 2). The AMNPs (1-AMNPs and 2-AMNPs) linked conjugates depicted increased triplet quantum yields in comparison to their unlinked Pcs, while 3-AMNPs showed a decrease compared to 3. The complexes showed increased in-vitro photocytotoxic effect against MCF-7 cells with an increase in drug concentration. At 80 mu g/mL, 2 and 3, 2-AMNPs and 3-AMNPs with higher singlet oxygen quantum yields caused more cytotoxic effect on the cancer cells in the presence of light as compared to 1 and 1-AMNPs respectively.
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