Article
Spectroscopy
Shin A. Yoon, Lavanya Gopala, Min Hee Lee
Summary: In this study, a biocompatible and activatable fluorescent molecular probe was developed to detect H2S generation in living cells with high selectivity and sensitivity. The probe showed specific response to H2S and emitted detectable fluorescence at 530 nm. It exhibited significant fluorescence responses to changes in endogenous H2S levels in living cells, allowing for real-time monitoring of endogenous H2S generation as an antioxidant defense response.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Medicinal
Baohui Qi, Fei Wang, Huan He, Mengmeng Fan, Liping Hu, Li Xiong, Guowei Gong, Shengmin Shi, Xiaomeng Song
Summary: In this study, a series of novel quinoline derivates were designed, synthesized, and evaluated for their biological activity. Compound 8m showed potent c-Met and Ron inhibitory activity, as well as cytotoxic activity against various cancer cell lines. Isomer (S)-8m demonstrated high selectivity towards COLO 205 cells and low cytotoxicity against normal tissue cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Hosam Choi, Joohee Choi, Jongyeol Han, Kiyoun Lee
Summary: A seven step asymmetric total synthesis of gymnothelignan N is presented, which is based on an early-stage one-carbon homologative lactonization reaction. The synthesis method allows for the rapid and effective assembly of optically active compounds using the same chiral intermediate. This represents one of the shortest and highest-yielding syntheses reported to date.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jin Huang, Hao Wang, Chunyang Chen, Shengzhong (Frank) Liu
Summary: All-inorganic perovskite CsPbI3 is a promising light-absorbing layer material, but defects can negatively affect the performance of perovskite solar cells (PSCs). To improve the performance of CsPbI3, a new additive PB is introduced, which can improve the morphology of the perovskite film, reduce the density of defect states, and enhance carrier transport properties. The optimized CsPbI3 PSC achieved high efficiency and improved stability.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Organic
Xinyu Xu, Mingjie Ou, Yan-En Wang, Tingzhi Lin, Dan Xiong, Fei Xue, Patrick J. Walsh, Jianyou Mao
Summary: In this study, a novel method was developed for the synthesis of 7-azaindoles and 7-azaindolines, which are important in medicinal chemistry. The chemoselectivity of the reaction depends on the counterions used, with different products obtained using LiN(SiMe3)(2) and KN(SiMe3)(2). Various substituents can also be introduced under these conditions.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Mariana Alves Ribeiro, Iolanda Frota de-Farias, Paulo Tarso Cavalcante Freire, Alejandro Pedro Ayala, Gustavo Antonio Ferreira de-Melo, Daniel Linhares Militao Vasconcelos, Antonio Cesar Honorato Barreto, Francisco Wagner Queiroz Almeida-Neto, Debora Hellen Almeida de-Brito, Paulo Nogueira Bandeira, Helcio Silva-dos-Santos, Telma Leda Gomes de-Lemos, Alexandre Magno Rodrigues Teixeira
Summary: This study investigates the structural, vibrational, electronic, and non-linear optical properties of a novel chalcone crystal. The crystal was characterized using various techniques such as X-ray diffraction, Raman spectroscopy, infrared spectroscopy, and UV-Vis spectroscopy. The results show that the crystal has a monoclinic structure and exhibits good optical and thermal stability.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Engineering, Environmental
Lun Huang, Shaohua Jin, Fang Bao, Shuxian Tang, Jueying Yang, Kelin Peng, Yu Chen
Summary: This study successfully prepared a hydrogel for NTO wastewater treatment by screening polymer materials, investigating its structure and adsorption performance, and further studying the adsorption kinetics, isotherm, and thermodynamics, ultimately achieving successful release and recovery of adsorbed NTO.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biology
Li Xu, Hong-Bo Jiang, Jie-Ling Yu, Deng Pan, Yong Tao, Quan Lei, Yang Chen, Zhao Liu, Jin-Jun Wang
Summary: Gravid female fruit flies show a strong preference for 1-octen-3-ol, a volatile compound from mango, and two odorant receptors have been identified as key receptors for 1-octen-3-ol perception. This research may contribute to the development of attractants for fruit flies.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Summary: In this study, the efficacy of milademetan, an MDM2 inhibitor, was assessed in various MCC models, showing significant inhibition on WT p53 MCC tumors. Useful in vitro and in vivo models for future MCC studies were also reported.
Article
Crystallography
Marcin Rojkiewicz, Piotr Kus, Joachim Kusz, Maria Ksiazek, Dorota Staszek
Summary: This paper describes and characterizes two cathinone derivatives, 4F-3Me-a-PVP and N-ethylheptedrone, seized on the illegal drug market in Poland through various instrumental analytical methods. The compounds were identified using electrospray ionization mass spectrometry, high-resolution mass spectrometry, gas chromatography-mass spectrometry, infrared spectroscopy, X-ray crystallography, thermogravimetric analysis, differential scanning calorimetry, and nuclear magnetic resonance spectroscopy. These analytical data are important for the rapid and reliable identification of compounds for forensic and toxicological purposes.
Article
Chemistry, Inorganic & Nuclear
Nane A. Avagyan, Pavel S. Lemport, Vitaly A. Roznyatovsky, Mariia V. Evsiunina, Petr I. Matveev, Mikhail A. Gerasimov, Konstantin A. Lyssenko, Victoria E. Goncharenko, Victor N. Khrustalev, Pavel V. Dorovatovskii, Boris N. Tarasevich, Alexei A. Yakushev, Alexei D. Averin, Igor P. Gloriozov, Vladimir G. Petrov, Yuri A. Ustynyuk, Valentine G. Nenajdenko
Summary: A highly efficient synthetic approach was developed for the synthesis of unsymmetrical 1,10-phenanthroline-2,9-diamides with different substituents. The structures of these ligands were confirmed and their binding properties with lanthanide nitrates were investigated. The study also quantitatively measured the binding constants and performed extraction experiments for these compounds.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Jianli Zheng, Yingqian Xu, Shaorui Song, Ling Huang, Dongdong Cao, Aiguo Zhong, Jianguo Yang, Dingben Chen
Summary: The photoredox-catalyzed 1,6-difluoromethylation of 3-methyl-4-nitro-5-styrylisoxazole with HCF2SO2Na has been developed, yielding structurally diverse difluoromethylated products. The di-, tri-, and monofluoromethylation were compared, showing the highest yield for difluoromethylation. DFT calculations revealed the nucleophilicity of CF2H radical and the lowest transition state activation energy in the difluoromethylation reaction.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Analytical
Anna Kielbasa, Boguslaw Buszewski, Renata Gadzala-Kopciuch
Summary: Breast milk is a valuable source of nutrients, including important fatty acids such as polyunsaturated fatty acids. The content of fatty acids in breast milk is influenced by various factors, and a method for isolating and quantifying these fatty acids can be effectively used in research and analysis.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
A. Thamarai, M. Raja, S. Sakthivel, S. Kumaran, S. Muthu, B. Narayana, P. Ramesh, S. Sevvanthi, Saleem Javed, B. Nagaraja Naick, Ahmad Irfan
Summary: In this study, a chlorophenyl substituted chalcone derivative molecule, BCPO, was synthesized and characterized using spectroscopic techniques. The molecular structures of BCPO and its derivatives, BHPO and BNPO, were optimized, and their vibration frequencies were compared with experimental data. The molecular reactivity and properties of BCPO, BHPO, and BNPO were investigated using various computational methods. The antimalarial activities of these molecules were also evaluated using molecular docking analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Immunology
Angela Corona, Rita Meleddu, Olivier Delelis, Frederic Subra, Filippo Cottiglia, Francesca Esposito, Simona Distinto, Elias Maccioni, Enzo Tramontano
Summary: New HIV-1 inhibitors targeting multiple viral enzymatic functions with a single molecule have been discovered, maintaining dual inhibitory activity in the low micromolar range. Compound 10a shows the most potential for further development as a multitarget compound, particularly against HIV-1 integrase.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
