Journal
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
Volume 31, Issue 20, Pages 3132-3142Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10826070802480081
Keywords
Charged aerosol detector; Detection; High performance liquid chromatography; Mass spectrometry; Purity
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A new procedure for the determination of novel discovery drug substance purity was developed using LC-MS coupled with charged aerosol detection (CAD) in a walk up open access system and chromatographic purity service. Chemists require an accurate high throughput methodology to monitor reactions and to provide good assurance of final compound quality. There is a need for detection methodologies, which are accurate and precise and offer rapid, inexpensive evaluation of research compound purity without the need for specific validated drug reference standards. This new approach resulted in a more accurate assessment of purity in comparison to the standard UV approach. This technique has been successful as an approach for a walk up service for chemists and also as a chromatographic purity service at low pH.
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