Review
Pharmacology & Pharmacy
Elena V. V. Shmendel, Pavel A. A. Puchkov, Michael A. A. Maslov
Summary: The delivery of therapeutic nucleic acids is a promising approach for treating both inherited and acquired diseases. Folic acid and its lipoconjugates, which have low immunogenicity, high tumor penetration, and high affinity for a wide range of tumor cells, are used for targeted delivery. Liposomal gene delivery systems using folate lipoconjugates are discussed, along with important development steps such as rational design and size control.
Article
Multidisciplinary Sciences
Praneeth R. Kuninty, Karin Binnemars-Postma, Ahmed Jarray, Kunal P. Pednekar, Marcel A. Heinrich, Helen J. Pijffers, Hetty ten Hoopen, Gert Storm, Peter van Hoogevest, Wouter K. den Otter, Jai Prakash
Summary: In this study, engineered nanoliposomes mimic peroxidated phospholipids and specifically target tumor-associated macrophages. The nanoliposomes are efficiently taken up by M2 macrophages and can reduce premetastatic niche or tumor growth in vivo upon treatment with inhibitors or drugs.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Maxwell W. G. Miner, Heidi Liljenback, Jenni Virta, Salli Karna, Riikka Viitanen, Petri Elo, Maria Gardberg, Jarmo Teuho, Piritta Saipa, Johan Rajander, Hasan Mansour A. Mansour, Nathan A. Cleveland, Philip S. Low, Xiang-Guo Li, Anne Roivainen
Summary: Non-invasive imaging techniques, such as PET, are crucial for cancer detection, especially in difficult to biopsy or delicate organs like the brain. This study investigated the use of the folate analogue [F-18]FOL to detect orthotopic gliomas in a rat model and found that it accumulated primarily in tumor cells with an overexpression of folate receptors. Furthermore, the study showed an upregulation of folate receptors in human glioblastoma samples.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Eleonora Colombo, Davide Andrea Coppini, Simone Maculan, Pierfausto Seneci, Benedetta Santini, Filippo Testa, Lucia Salvioni, Giovanni Maria Vanacore, Miriam Colombo, Daniele Passarella
Summary: This study reports the self-assembly of hetero-nanoparticles composed of a conjugate with folic acid as the targeting agent and another conjugate with paclitaxel as the active agent. The hetero-nanoparticles with varying percentages of folic acid conjugates are characterized, and their biological activity is determined.
Article
Medicine, Research & Experimental
Juliana de Oliveira Silva, Renata Salgado Fernandes, Janaina de Alcantara Lemos, Geovanni Dantas Cassali, Adriano de Paula Sabino, Danyelle M. Townsend, Monica Cristina Oliveira, Andre Luis Branco de Barros
Summary: Recently, folate-coated pH-sensitive liposomes have been studied as a tool to enhance cellular uptake and antitumor activity of paclitaxel and doxorubicin. This study demonstrated the importance of folate functionalization in doxorubicin-loaded liposomes and showed their significant reduction in cardiac toxicity. This provides a promising drug delivery strategy for the treatment of breast tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Ruo-Yun Zhang, Kai Cheng, Yang Xuan, Xiao-Quan Yang, Jie An, Yong-Guo Hu, Bo Liu, Yuan-Di Zhao
Summary: In this study, a new enteric-coated granule was designed for the combined sonodynamic-chemotherapy treatment of inflammatory colorectal cancer in a mouse model. The granule showed effective targeting and controlled release, resulting in desired treatment outcomes and prognosis.
Article
Immunology
Milena Kalaitsidou, Owen R. Moon, Martina Sykorova, Leyuan Bao, Yun Qu, Sujita Sukumaran, Michael Valentine, Xingliang Zhou, Veethika Pandey, Kay Foos, Sergey Medvedev, Daniel J. Powell Jr, Akshata Udyavar, Eric Gschweng, Ruben Rodriguez, Mark E. Dudley, Robert E. Hawkins, Gray Kueberuwa, John S. Bridgeman
Summary: Transfer of autologous tumor infiltrating lymphocytes (TIL) has shown clinical efficacy in refractory melanoma patients, but extending this benefit to other cancers is challenging. In this study, a chimeric costimulatory receptor called CoStAR was developed, which enhances T cell activity and improves TIL therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xu Zhou, Dandan Huang, Runkong Wang, Mingquan Wu, Liyang Zhu, Wei Peng, He Tu, Xuangeng Deng, He Zhu, Zhong Zhang, Xinming Wang, Xi Cao
Summary: The use of folic acid-modified liposomes containing triptolide has been shown to be effective in treating rheumatoid arthritis by targeting M1 macrophages and repolarizing macrophages from M1 to M2 subtypes, achieving precise inflammation therapy.
Article
Biochemistry & Molecular Biology
Yoonyoung Kim, Yu Seok Youn, Kyung Taek Oh, Dongin Kim, Eun Seong Lee
Summary: The strategy of transient hole formation on liposomes allows safe encapsulation of high-molecular weight antibodies, leading to enhanced release and biological effects in vivo.
Review
Pharmacology & Pharmacy
Joel Hardwick, Jack Taylor, Meenu Mehta, Saurabh Satija, Keshav R. Paudel, Philip M. Hansbro, Dinesh K. Chellappan, Mary Bebawy, Kamal Dua
Summary: Curcumin, a compound found in turmeric, has various therapeutic properties and has been used for centuries in treating different ailments. Recent studies have focused on its potential as a novel therapeutic agent in cancer treatment, although its mechanisms of action are still not fully understood. Improving its bioavailability and stability through advancements in drug delivery systems, such as nanoparticle-based vesicular drug delivery platforms, holds promise for enhancing its therapeutic effects. Specifically, curcumin-encapsulated niosomes show potential in improving the delivery of challenging small molecules and may pave the way for innovative pharmaceutical drug delivery applications in various industries.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Biochemistry & Molecular Biology
Xiao Fu, Yingni He, Mu Li, Zezhi Huang, Masoud Najafi
Summary: The tumor microenvironment consists of various cells and molecules that influence the survival and growth of cancer cells, understanding the impact of immunosuppressive cells on tumors is crucial for cancer treatment. Curcumin has been shown to have the ability to inhibit cancer cell growth and modulate immunosuppressive cells, making it beneficial for tumor therapy.
Article
Nanoscience & Nanotechnology
Sendibitiyosi Gandidzanwa, Natasha Beukes, Sinelizwi Joseph, Arno Janse Van Vuuren, Philani Mashazi, Jonathan Britton, Gareth Kilian, Saartjie Roux, Tebello Nyokong, Michael E. Lee, Carminita L. Frost, Zenixole R. Tshentu
Summary: Folate receptor-targeted therapy shows promise in breast cancer treatment. Folate-conjugated palladium-based nanoparticles with non-toxic concentrations were utilized to specifically target breast cancer cells with overexpressed folate receptors. The nanoparticles were found to selectively accumulate in cancer cells relative to normal cells, as demonstrated by qualitative and quantitative analysis using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. These findings support the potential use of folate-conjugated palladium nanoparticles in targeting breast cancer cells for radiopharmaceutical applications.
Article
Chemistry, Multidisciplinary
Yong Il Park, Seung-Hae Kwon, Gibok Lee, Keiichi Motoyama, Min Woo Kim, Min Lin, Takuro Niidome, Jung Hoon Choi, Ruda Lee
Summary: NSCLC is the leading cause of lung cancer-related deaths, with TAMs and CAPN2 playing important roles. It is crucial to develop smart drug delivery systems with specific targeting ability and controlled release mechanisms to enhance anticancer drug efficacy and reduce side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Nanoscience & Nanotechnology
Cuiping Qi, Di Wang, Xue Gong, Qiyang Zhou, Xinxin Yue, Chenglei Li, Zhipeng Li, Guixiang Tian, Bo Zhang, Qing Wang, Xiuhong Wei, Jingliang Wu
Summary: Recent studies have shown that the low survival rate of liver cancer is attributed to drug resistance and metastasis. In this study, a novel multifunctional liposome was developed for dual-targeting liver cancer by inhibiting the activation of hepatic stellate cells and the migration of tumor cells, demonstrating superior antitumor effects in in vivo models.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Changwei Hu, Xirui Wang, Yabin Li, Xiaoyong Han, Baowen Ren, Gangfeng Yin
Summary: In this study, folate-conjugated dual-drug loaded double liposomes with high target specificity towards pituitary adenomas were synthesized. These liposomal formulations were highly targeted, with suitable size to evade body clearance mechanisms, and exhibited high specificity towards the targeted tissue through cellular uptake studies. This approach showed promising potential as a low cytotoxicity and high-specificity therapy for the future.
JOURNAL OF EXPERIMENTAL NANOSCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Jun Hu, Ashkan Dehsorkhi, Wafa T. Al-Jamal, Yan Zhang, Siying Chen, Chuanyu Yang, Dan Tan, Qing Zhao, Chang Yang, Yonglin Wang
NANOSCIENCE AND NANOTECHNOLOGY LETTERS
(2017)
Article
Nanoscience & Nanotechnology
Nan Ding, Yao Lu, Robert J. Lee, Chang Yang, Lei Huang, Jian Liu, Guangya Xiang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2011)
Article
Nanoscience & Nanotechnology
Santana Bala Lakshmanan, Xiaoju Zou, Marius Hossu, Lun Ma, Chang Yang, Wei Chen
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2012)
Article
Nanoscience & Nanotechnology
Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken, Renfei Feng, Guangya Xiang, Wei Chen
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2013)
Article
Pharmacology & Pharmacy
Xiaolan Qu, Chang Yang, Jing Zhang, Nan Ding, Yao Lu, Lei Huang, Guangya Xiang
JOURNAL OF DRUG TARGETING
(2010)
Article
Pharmacology & Pharmacy
Chang Yang, Nan Ding, Yibing Xu, Xiaolan Qu, Jing Zhang, Chaoyang Zhao, Liang Hong, Yao Lu, Guangya Xiang
JOURNAL OF DRUG TARGETING
(2009)
Article
Nanoscience & Nanotechnology
Yi-Hsuan Tseng, Yuan He, Santana Lakshmanan, Chang Yang, Wei Chen, Long Que
Article
Biochemical Research Methods
Ebenezer Addae, Xiuli Dong, Eric McCoy, Chang Yang, Wei Chen, Liju Yang
JOURNAL OF BIOLOGICAL ENGINEERING
(2014)
Article
Integrative & Complementary Medicine
Hui-Yuan Sun, Lin Zheng, Zi-Peng Gong, Yue-Ting Li, Chang Yang, Jie Pan, Yong-Lin Wang, Ai-Min Wang, Yong-Jun Li, Yong Huang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Biochemical Research Methods
Chang Yang, Tao Xia, Changquan Wang, Huiyuan Sun, Yongjun Li, Zipeng Gong, Yueting Li, Lin Zheng, Yong Huang
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Medicine, Research & Experimental
Chang Yang, Qing Zhao, Shanshan Yang, Libin Wang, Xingyuan Xu, Lisu Li, Wafa T. Al-Jamal
Summary: This study investigates the protective effect of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with scutellarin (SCU) in reducing cerebral ischemia/reperfusion (I/R) injury. The results show that SCU-PLGA NPs can increase SCU levels in the ischemic brain, reduce cerebral infarct volume, reverse histopathological changes, and attenuate cell apoptosis in the brain tissue.
MOLECULAR PHARMACEUTICS
(2022)