Article
Biochemistry & Molecular Biology
Darshan Mehta, Sayoni Roy, Priyanka Joshi, Mitali Parab, Sanjeev K. Waghmare
Summary: Breast cancer stem cells (BCSCs) are slow cycling cells that escape traditional chemo-radiotherapy, contributing to resistance and recurrence. This study isolated BCSCs using the marker CD44+/CD24-/low and found that they had a high percentage of mammospheres in the CSC population. The tumorigenic potential of BCSCs was observed in vivo, and the overexpression of sPLA2-IIA in breast cancer cells was found to be associated with cell proliferation and metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Syed Nasir Abbas Bukhari
Summary: Complex diseases such as cancer are often caused by various disorders, gene mutations, or pathways. This study synthesized and tested several chalcone compounds for their anticancer activity and found that most of them showed strong activity against multiple cancer cell lines. Two compounds in particular exhibited excellent antiproliferative activity compared to the positive control. Further structural and docking studies provided insights into their possible binding patterns, suggesting potential for developing multitarget anticancer agents.
Article
Pharmacology & Pharmacy
Milica Markovic, Shimon Ben-Shabat, Jagadeesh Nagendra Manda, Karina Abramov-Harpaz, Clil Regev, Yifat Miller, Aaron Aponick, Ellen M. Zimmermann, Arik Dahan
Summary: This study developed a prodrug using phospholipid to specifically target and treat inflammation in the gastrointestinal tract. The prodrug was activated by the enzyme phospholipase A(2), which is overexpressed in diseased tissues. The results showed successful activation of the prodrug in diseased tissues, validating the drug targeting strategy.
Article
Cell Biology
Yu Maw Htwe, Huashan Wang, Patrick Belvitch, Lucille Meliton, Mounica Bandela, Eleftheria Letsiou, Steven M. Dudek
Summary: The study demonstrates the important role of gVPLA(2) in mediating lung endothelial permeability and ALI induced by MRSA. This suggests that gVPLA(2) may be a novel therapeutic target for ALI/ARDS caused by bacterial infection.
Article
Immunology
M. D. Milan Gowda, K. Jayachandra, Vikram Joshi, Vaddarahally N. Manjuprasanna, Gotravalli Rudresha, Devadasan Velmurugan, Raman Pachaiappan, Noor Mohamed Jameel, Bannikuppe S. Vishwanath
Summary: This study aimed to investigate the potential anti-inflammatory properties of a molecule called syringol isolated from Eleusine coracana. The molecule exhibited significant inhibition of enzymes involved in inflammation and reduced the expression of inflammation-related proteins in edematous tissues. These findings suggest that syringol may serve as a potent anti-inflammatory molecule.
INFLAMMOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Frans A. Kuypers, Christina A. Rostad, Evan J. Anderson, Ann Chahroudi, Preeti Jaggi, Jens Wrammert, Grace Mantus, Rajit Basu, Frank Harris, Bradley Hanberry, Andres Camacho-Gonzalez, Shaminy Manoranjithan, Miriam Vos, Lou Ann Brown, Claudia R. Morris
Summary: sPLA2 levels were found to be significantly elevated in children hospitalized with severe COVID-19, compared to adults with recent COVID-19 infection and asymptomatic individuals. Acute MIS-C in children was also associated with higher sPLA2 levels, suggesting a role in disease pathogenesis and potential use as a biomarker for risk stratification and patient management. Therapeutic compounds targeting sPLA2 and inflammasome activation may be worth considering based on these findings.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Surgery
Anna K. Gergen, Michael J. Jarrett, Anqi Li, Allana M. White, Xianzhong Meng, David A. Fullerton, Michael J. Weyant
Summary: Inhibiting sPLA(2) in human Barrett's cells can decrease cellular adhesive properties and NF-kappa B activation, as well as reduce cell proliferation, indicating a downregulation of the inflammatory response and potential attenuation of cellular malignant properties. This suggests that sPLA(2) inhibition could be a chemopreventive target for premalignant lesions of the esophagus.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhang Shan, Gong Wei-Kang, Zhang Na, Li Chun-Hua
Summary: This study analyzed the dynamics and allosteric behavior of human sPLA2-IIA members, and explored the relationship between their shared/specific dynamics and functions. The results showed that certain regions had high mobility, which correlated with specific functions, while other residues with low sensitivity played a role in maintaining structural stability.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Akhlaq A. Farooqui, Tahira Farooqui, Grace Y. Sun, Teng-Nan Lin, Daniel B. L. Teh, Wei-Yi Ong
Summary: Although the underlying mechanism(s) of how oxidative stress and inflammation induced by COVID-19 contribute to thrombosis risk and severity is not fully understood, this review highlights the role of blood lipids, particularly sPLA(2)-IIA metabolites, in COVID-19-associated coagulopathy (CAC). Increased levels of sPLA(2)-IIA and its metabolites, such as arachidonic acid and lysophospholipids, have been observed in the serum of COVID-19 patients. These lipid mediators can induce pro-coagulation and vasoconstriction, as well as trigger clotting mechanisms like NETosis. The findings suggest that blood lipid analysis may provide insights into the pathogenesis of CAC in COVID-19.
Article
Neurosciences
Wei-Yi Ong, Mei-Lin Go, De-Yun Wang, Irwin Kee-Mun Cheah, Barry Halliwell
Summary: COVID-19 affects not only peripheral organs but also the central nervous system, and antimalarials have unique properties that enable them to cross the blood-brain barrier and inhibit inflammatory responses.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ole G. Mouritsen, Lars Duelund, Mikael Agerlin Petersen, Anna Loraine Hartmann, Michael Bom Frost
JOURNAL OF APPLIED PHYCOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Jose Lucas Perez-Llorens, Ole G. Mouritsen, Prannie Rhatigan, M. Lynn Cornish, Alan T. Critchley
JOURNAL OF APPLIED PHYCOLOGY
(2020)
Article
Chemistry, Applied
Charlotte Vinther Schmidt, Karsten Olsen, Ole G. Mouritsen
Summary: The study measured the FAA contents of selected fermented beverages using UHPLC and found that sakes, beers, wines, and champagnes with long yeast contact contain significant amounts of free glutamate. The results suggest that combining these fermented beverages with food rich in free nucleotides can achieve umami synergy.
Article
Multidisciplinary Sciences
Charlotte Vinther Schmidt, Karsten Olsen, Ole G. Mouritsen
SCIENTIFIC REPORTS
(2020)
Article
Food Science & Technology
Charlotte Vinther Schmidt, Mahesha M. Poojary, Ole G. Mouritsen, Karsten Olsen
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2020)
Article
Food Science & Technology
Charlotte Vinther Schmidt, Lorenz Plankensteiner, Peter Lionet Faxholm, Karsten Olsen, Ole G. Mouritsen, Michael Bom Frost
Summary: This study assessed the effects of sous vide cooking time and temperature on the eating quality of squid, finding that cooking at 55 degrees Celsius provides a good compromise between texture and juiciness.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2021)
Article
Food Science & Technology
Charlotte Vinther Schmidt, Lorenz Plankensteiner, Mathias Porsmose Clausen, Anders Runge Walhter, Jacob Judas Kain Kirkensgaard, Karsten Olsen, Ole G. Mouritsen
Summary: The study focused on sous vide cooking of squid mantles at various temperatures and times, analyzing the macroscopic textural properties, collagen content, and structural changes. Collagen was found to be the major protein responsible for cooking loss and both collagen and actin significant for mechanical textural changes. Lower temperature cooking resulted in decreased cooking loss with minimal changes in most textural parameters. Further investigation into optimized cooking conditions is recommended, potentially enhancing the gastronomic use of squid mantles as a nutritious protein resource.
JOURNAL OF FOOD SCIENCE
(2021)
Review
Food Science & Technology
Charlotte Vinther Schmidt, Ole G. Mouritsen
Summary: Foods are complex systems with hierarchical structures that influence texture and taste. Cephalopods, known for their challenging texture, are rich in compounds that elicit umami taste. Scientific investigations of cephalopods as foods require mechanical studies, physicochemical measurements, and chemical analysis. The combination of basic science and exploration of gastronomic potential is called gastrophysics.
Review
Biotechnology & Applied Microbiology
J. L. Perez-Llorens, A. T. Critchley, M. L. Cornish, O. G. Mouritsen
Summary: The benefits of various seaweeds have long been recognized by humans, especially by coastal dwellers and those who use seaweeds as food and medicine. Their positive effects are likely due to the presence of hydrocolloids and bioactive compounds. This compilation of excerpts from major medical publications and esteemed writers provides a rich background supporting the positive applications of seaweeds for various human ailments.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Food Science & Technology
Ole G. Mouritsen
Summary: Roe refers to the eggs or whole gonads of fish, crustaceans, mollusks, and echinoderms. It is not only a source of nutrients for animals in the sea, but also a popular food among humans. From cod roe to caviar, roe is consumed in various forms and holds a rich gastronomic history. With its high omega-3 fatty acid content and unique taste, roe is valued for its nutrition and culinary uses. This article explores the diverse types of roe beyond sturgeon, such as flat fish, codfish, mullet, smelt, trout, herring, crab, shrimp, and octopus, as well as caviar substitutes made from fish meat and seaweeds. It argues for the sustainable and creative use of roe, including enhancing the umami flavor of vegetable and green dishes.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Letter
Food Science & Technology
Ole G. Mouritsen
Article
Biotechnology & Applied Microbiology
Ole G. Mouritsen, Prannie Rhatigan, M. Lynn Cornish, Alan T. Critchley, Jose Lucas Perez-Llorens
Summary: Seaweeds are crucial contributors to Earth's production of organic matter and oxygen, as well as a nutritious food source. Throughout history, seaweeds have played a significant role in saving humans during times of crises. Lessons learned from these interactions can guide us in how to utilize seaweeds to address future challenges.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Psychology, Multidisciplinary
Ole G. Mouritsen, Charlotte Vinther Schmidt
FRONTIERS IN PSYCHOLOGY
(2020)
Article
Psychology, Multidisciplinary
Charlotte Vinther Schmidt, Ole G. Mouritsen
FRONTIERS IN PSYCHOLOGY
(2020)
Review
Food Science & Technology
Pia M. Sorensen, Ole G. Mouritsen
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2019)