Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids

β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels

(2015) Chuck T. Chen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lithium and the Other Mood Stabilizers Effective in Bipolar Disorder Target the Rat Brain Arachidonic Acid Cascade

(2014) Stanley I. Rapoport   ACS Chemical Neuroscience

Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model

(2014) Marc-Olivier Trépanier et al.   EPILEPSY & BEHAVIOR

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Inhibiting Mitochondrial β-Oxidation Selectively Reduces Levels of Nonenzymatic Oxidative Polyunsaturated Fatty Acid Metabolites in the Brain

(2013) Chuck T Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms

(2013) Chuck T. Chen et al.   JOURNAL OF LIPID RESEARCH

Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

(2013) Anthony F. Domenichiello et al.   JOURNAL OF LIPID RESEARCH

EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials

(2013) Julian G Martins   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: A randomized trial

(2013) Christopher E. Ramsden et al.   PAIN

Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses

(2012) Marc-Olivier Trépanier et al.   EPILEPSY RESEARCH

Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis

(2012) J G Martins et al.   MOLECULAR PSYCHIATRY

Dietary intake of n−3 and n−6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study

(2011) Michel Lucas et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's, and Other Neurodegenerative Diseases

(2011) Nicolas G. Bazan et al.   Annual Review of Nutrition

DHA is essential, EPA appears largely expendable, in meeting the n−3 long-chain polyunsaturated fatty acid requirements of juvenile cobia Rachycentron canadum

(2011) Jesse Trushenski et al.   AQUACULTURE

α-Synuclein Neuropathology is Controlled by Nuclear Hormone Receptors and Enhanced by Docosahexaenoic Acid in A Mouse Model for Parkinson's Disease

(2011) Eugenia Yakunin et al.   BRAIN PATHOLOGY

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Regulation of rat brain polyunsaturated fatty acid (PUFA) metabolism during graded dietary n-3 PUFA deprivation

(2011) Hyung-Wook Kim et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Linoleic acid recommendations—A house of cards

(2011) S.C. Cunnane et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

α-Linolenate reduces the dietary requirement for linoleate in the growing rat

(2011) P. Guesnet et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain

(2010) Hyung-Wook Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

(2010) Chuck T. Chen et al.   JOURNAL OF NEUROCHEMISTRY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

ESSENTIAL FATTY ACIDS

(2010) Ralph T. Holman   NUTRITION REVIEWS

Brain phospholipid arachidonic acid half-lives are not altered following 15 weeks of N-3 polyunsaturated fatty acid adequate or deprived diet

(2009) Joshua T. Green et al.   JOURNAL OF LIPID RESEARCH

Brain lipid concentrations in bipolar disorder

(2009) Miki Igarashi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Rapid β-oxidation of eicosapentaenoic acid in mouse brain: An in situ study

(2009) Chuck T. Chen et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats

(2008) Miki Igarashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mode of action of mood stabilizers: is the arachidonic acid cascade a common target?

(2008) J S Rao et al.   MOLECULAR PSYCHIATRY

Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease

(2008) Stanley I. Rapoport   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Nutritional Deprivation of α-Linolenic Acid Decreases but Does Not Abolish Turnover and Availability of Unacylated Docosahexaenoic Acid and Docosahexaenoyl-CoA in Rat Brain

(2002) Miguel A. Contreras et al.   JOURNAL OF NEUROCHEMISTRY