Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Latifa Alketbi, Abeer Al-Ali, Iman M. Talaat, Qutayba Hamid, Khuloud Bajbouj
Summary: Colorectal cancer (CRC) is a common malignancy worldwide, ranked fourth in cancer-related deaths. Mutations in oncogenes, tumor suppressor genes, and DNA repair genes contribute to the development of CRC. Chemoresistance is one of the major challenges in CRC treatment, and the overexpression of ATP-binding cassette (ABC) transporters has been identified as a facilitating mechanism for chemoresistance. ABC transporters are involved in lipid transport and homeostasis, which play a crucial role in tumor development and progression. Altered expression of ABCA transporters in CRC is associated with poor prognosis and overall survival. This minireview suggests that ABCA transporters could serve as potential diagnostic and therapeutic targets in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Simiao Yu, Xue Qiao, Ying Yang, Xiaoyu Gu, Wending Sun, Xiyang Liu, Dan Zhang, Lingling Wang, Linsheng Song
Summary: In this study, a homologue of ABCG2 named CgABCG2 was identified in Pacific oyster C. gigas. CgABCG2 was mainly distributed on the cell membrane of haemocytes and its mRNA expression level increased significantly after Vibrio splendidus stimulation. Interference of CgABCG2 expression led to reduced proliferation of haemocytes, down-regulation of hematopoiesis-related transcription factors, and arrest at the G0/G1 phase of the cell cycle. These findings suggest that CgABCG2 is involved in the proliferation of haemocytes in oyster C. gigas.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao
Summary: In this study, a scavenger receptors AI (SR-AI) targeted theranostic nanoparticles were constructed to target foam cells and atherosclerotic plaques via ABCA1 activation. The SAU-NPs showed more active targeting to plaque lesions compared to non-SR-AI targeted nanoparticles. SAU-NPs carrying 5242331 inhibited the transformation to foam cells and effectively reduced cholesterol deposition through activating the LXR & alpha;-ABCA1/ABCG1/SR-BI pathway.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Min Zhu, Longfei Jia, Jianping Jia
Summary: The study identified miR-96-5p as the upstream miRNA for ABCA1, and inhibition of miR-96-5p in AD models could reduce A beta(42)/A beta(40) ratios by upregulating the expression of ABCA1, indicating an important role of miR-96-5p in regulating A beta content.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-ichi Yamada, Makoto Suematsu, Masaki Ieda, Motoaki Sano
Summary: This study found that glutathione release during ischemia-reperfusion (IR) is primarily dependent on the transporter MRP1, and its release induces ferroptosis. Suppression of glutathione release attenuates ferroptosis and reduces myocardial infarct size following IR.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Su Mon Shwe, Sivaprasath Prabu, Dapeng Jing, Kanglai He, Zhenying Wang
Summary: The Cry1Ah and Vip3Aa19 proteins have a synergistic interaction in controlling the Yellow peach moth. Cry1Ah has a higher binding affinity for midgut receptors compared to Vip3Aa19, and there is no competition between them.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Silpa Narayanan, Nehaben A. Gujarati, Jing-Quan Wang, Zhuo-Xun Wu, Jagadish Koya, Qingbin Cui, Vijaya L. Korlipara, Charles R. Ashby, Zhe-Sheng Chen
Summary: The study showed that the novel benzamide derivative VKNG-2 can reverse MDR caused by overexpression of ABCG2 transporter in colon cancer cells; VKNG-2 significantly improves the efficacy of anticancer drugs in vitro and works by inhibiting the efflux function of the ABCG2 transporter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Fiza Liaquat, Muhammad Farooq Hussain Munis, Samiah Arif, Muhammad Aamir Manzoor, Urooj Haroon, Iftikhar Hussain Shah, Muhammad Ashraf, Hyun Seok Kim, Shengquan Che, Liu Qunlu
Summary: This study investigated the differential gene expression of Schima superba under Mn metal stress through transcriptomic analysis. The differentially expressed genes were found to be involved in defense, signaling pathways, oxidative burst, transcription factors, and stress responses. The results provide insights into the metal resistance mechanisms and contribute to the understanding of heavy metal tolerance and detoxification.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rossana Visigalli, Bianca Maria Rotoli, Francesca Ferrari, Maria Di Lascia, Benedetta Riccardi, Paola Puccini, Valeria Dall'Asta, Amelia Barilli
Summary: In this study, the expression and activity of ABC transporters in human alveoli were analyzed. The results showed that MRP1 was the only transporter expressed and functional at the basolateral side, while the other studied transporters were not expressed on the apical membrane. This suggests the presence of unidentified transporters involved in drug efflux from alveolar epithelium.
Article
Biochemistry & Molecular Biology
Yaolei Mi, Xue Cao, Xuewen Zhu, Weiqiang Chen, Xiangxiao Meng, Huihua Wan, Wei Sun, Sifan Wang, Shilin Chen
Summary: This study identified and characterized 113 ABC transporters in C. sativa, and proposed seven core transporters that may participate in cannabinoid transport. These candidate genes showed high correlation with cannabinoid biosynthetic pathway genes and content, and were highly expressed in cannabinoid biosynthesis and accumulation sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Feng Cheng, Mengfei Song, Mengru Zhang, Gaohui Zha, Juan Yin, Chunyan Cheng, Jinfeng Chen, Qunfeng Lou
Summary: Leaf architecture, including leaf position and morphology, plays a crucial role in determining plant appearance and productivity. In this study, we identified a mutant cucumber with an erect and compact leaf architecture caused by a mutation in the CsABCB19 gene. Histological examination revealed that asymmetric cell expansion was responsible for the phenotypic variation in the mutant. Transcriptome analysis showed differential expression of auxin and polarity-related genes in mutant tissues. Further investigations demonstrated that CsABCB19 regulates leaf architecture by mediating auxin accumulation and transport. This study provides new insights into the genetic mechanisms controlling leaf development in cucumber.
Article
Pharmacology & Pharmacy
Maria Lajarin-Reinares, Iria Naveira-Souto, Mireia Mallandrich, Joaquim Suner-Carbo, Montserrat Llagostera Casas, Maria Angels Calvo, Francisco Fernandez-Campos
Summary: This study aimed to develop and optimize a mucoadhesive drug delivery system for the local administration of disulfiram. The results showed that these gels had antifungal activity against Candida albicans, Candida parapsilosis, and Nakaseomyces glabratus. The physicochemical properties and release profiles of the gels were also characterized and investigated.