Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

(2011) Min Wan et al.   Cell Metabolism

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Positional Cloning of a Type 2 Diabetes Quantitative Trait Locus; Tomosyn-2, a Negative Regulator of Insulin Secretion

(2011) Sushant Bhatnagar et al.   PLoS Genetics

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

(2010) P. Chakrabarti et al.   DIABETES

Role of the TSC1-TSC2 Complex in the Integration of Insulin and Glucose Signaling Involved in Pancreatic β-Cell Proliferation

(2010) Alberto Bartolomé et al.   ENDOCRINOLOGY

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet-induced hepatocellular carcinoma in genetically predisposed mice

(2009) A. E. Hill-Baskin et al.   HUMAN MOLECULAR GENETICS

Renal and liver tumors in Tsc2+/- mice, a model of tuberous sclerosis complex, do not respond to treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

(2009) G. A. Finlay et al.   MOLECULAR CANCER THERAPEUTICS

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

(2009) Hui H. Zhang et al.   PLoS One

AMPK represses TOP mRNA translation but not global protein synthesis in liver

(2008) Ali K. Reiter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD)

(2008) Masato Yoneda et al.   BMC GASTROENTEROLOGY

Widespread hyperplasia induced by transgenic TGF  in ApcMin mice is associated with only regional effects on tumorigenesis

(2008) A. Bilger et al.   CARCINOGENESIS

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA