Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression

Causal reasoning on biological networks: interpreting transcriptional changes

(2012) Leonid Chindelevitch et al.   BIOINFORMATICS

Dihydroceramide-based Response to Hypoxia

(2011) Cecilia M. Devlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroceramide desaturase activity is modulated by oxidative stress

(2010) Jolanta Idkowiak-Baldys et al.   BIOCHEMICAL JOURNAL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Identification and Characterization of Dual Inhibitors for Phospholipid Transfer Protein and Microsomal Triglyceride Transfer Protein

(2010) Y. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol☆

(2009) Zhiqiang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic nuclear factor 1-α: inflammation, genetics, and atherosclerosis

(2009) Angela D Armendariz et al.   CURRENT OPINION IN LIPIDOLOGY

Inherited lipodystrophies and hypertriglyceridemia

(2009) Vinaya Simha et al.   CURRENT OPINION IN LIPIDOLOGY

Analysis of Development of Lesions in Mice with Serine Palmitoyltransferase (SPT) Deficiency

(2009) Etsuko OHTA et al.   EXPERIMENTAL ANIMALS

The SPTLC3 Subunit of Serine Palmitoyltransferase Generates Short Chain Sphingoid Bases

(2009) Thorsten Hornemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels

(2009) Zhiqiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells

(2009) Wu Zhou et al.   MOLECULAR CARCINOGENESIS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages

(2008) Liliana Håversen et al.   ATHEROSCLEROSIS

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

SPTLC1 Binds ABCA1 To Negatively Regulate Trafficking and Cholesterol Efflux Activity of the Transporter†

(2008) Norimasa Tamehiro et al.   BIOCHEMISTRY

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

(2008) Steve S Choi et al.   CURRENT OPINION IN LIPIDOLOGY

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

(2008) J. M. Haus et al.   DIABETES

Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights fromin VivoManipulation of Sphingolipid Metabolism

(2008) William L. Holland et al.   ENDOCRINE REVIEWS

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

(2008) Susanne Schiffmann et al.   JOURNAL OF LIPID RESEARCH

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HMDB: a knowledgebase for the human metabolome

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

(2008) T PARK et al.   PHARMACOLOGICAL RESEARCH

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR