Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk
Published 2011 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk
Authors
Keywords
-
Journal
JOURNAL OF LIPID RESEARCH
Volume 52, Issue 11, Pages 1885-1926
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2011-08-24
DOI
10.1194/jlr.r017855
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Combined Effects of Ezetimibe and Phytosterols on Cholesterol Metabolism
- (2011) Xiaobo Lin et al. CIRCULATION
- Molecular Basis of Autosomal Dominant Hypercholesterolemia
- (2011) Anouk van der Graaf et al. CIRCULATION
- PCSK9: an emerging target for treatment of hypercholesterolemia
- (2011) Christopher J Duff et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B
- (2011) Wei Qiu et al. HEPATOLOGY
- Phytosterol ester processing in the small intestine: impact on cholesterol availability for absorption and chylomicron cholesterol incorporation in healthy humans
- (2011) Marie Josèphe Amiot et al. JOURNAL OF LIPID RESEARCH
- Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway
- (2011) Eric A. Fisher et al. JOURNAL OF LIPID RESEARCH
- Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease)
- (2011) Amandine Georges et al. Orphanet Journal of Rare Diseases
- A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice
- (2011) Gemma Brufau et al. PLoS One
- The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation
- (2011) Hyock Joo Kwon et al. PLoS One
- Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability
- (2011) Serena Sanna et al. PLoS Genetics
- Safety and Efficacy of Ezetimibe/Simvastatin Combination Versus Atorvastatin Alone in Adults ≥65 Years of Age With Hypercholesterolemia and With or at Moderately High/High Risk for Coronary Heart Disease (the VYTELD Study)
- (2010) JoAnne M. Foody et al. AMERICAN JOURNAL OF CARDIOLOGY
- Detection of Mutations and Large Rearrangements of the Low-Density Lipoprotein Receptor Gene in Taiwanese Patients With Familial Hypercholesterolemia
- (2010) Kuan-Rau Chiou et al. AMERICAN JOURNAL OF CARDIOLOGY
- Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System
- (2010) Jennifer Lippincott-Schwartz et al. Annual Review of Biophysics
- Familial Defective Apolipoprotein B-100 and Increased Low-Density Lipoprotein Cholesterol and Coronary Artery Calcification in the Old Order Amish
- (2010) Haiqing Shen et al. ARCHIVES OF INTERNAL MEDICINE
- Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans
- (2010) Lena Persson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Increased Secretion of Lipoproteins in Transgenic Mice Expressing Human D374Y PCSK9 Under Physiological Genetic Control
- (2010) Bronwen Herbert et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
- (2010) Dawn M. Waterworth et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population
- (2010) Anette Varbo et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Update of the Portuguese Familial Hypercholesterolaemia Study
- (2010) A.M. Medeiros et al. ATHEROSCLEROSIS
- Bile Acids Stimulate ATP Hydrolysis in the Purified Cholesterol Transporter ABCG5/G8
- (2010) Brandy J. Harvey Johnson et al. BIOCHEMISTRY
- Interfacial Properties of Apolipoprotein B292−593 (B6.4−13) and B611−782 (B13−17). Insights into the Structure of the Lipovitellin Homology Region in Apolipoprotein B
- (2010) Libo Wang et al. BIOCHEMISTRY
- Molecular Basis for the Differences in Lipid and Lipoprotein Binding Properties of Human Apolipoproteins E3 and E4
- (2010) David Nguyen et al. BIOCHEMISTRY
- Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assemblyThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.
- (2010) Angela C. Rutledge et al. Biochemistry and Cell Biology
- Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
- (2010) Michael L. Wang et al. Cell Metabolism
- Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export
- (2010) Mads Kjolby et al. Cell Metabolism
- Competitive solubilization of cholesterol and six species of sterol/stanol in bile salt micelles
- (2010) Keisuke Matsuoka et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese
- (2010) Yumiko Hiura et al. CIRCULATION JOURNAL
- Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease
- (2010) Daniel Teupser et al. Circulation-Cardiovascular Genetics
- Moderate phenotypic expression of familial hypercholesterolemia in Tunisia
- (2010) Awatef Jelassi et al. CLINICA CHIMICA ACTA
- Ezetimibe; More Than a Low Density Lipoprotein Cholesterol Lowering Drug? An Update After 4 Years
- (2010) Eirini Lioudaki et al. Current Vascular Pharmacology
- Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents
- (2010) Marianne Abifadel et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- NPC1L1 and cholesterol transport
- (2010) Jenna L. Betters et al. FEBS LETTERS
- Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population
- (2010) Stefan Stender et al. HEPATOLOGY
- Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica
- (2010) R. Gupta et al. HUMAN GENETICS
- Identification by whole-genome resequencing of gene defect responsible for severe hypercholesterolemia
- (2010) J. Rios et al. HUMAN MOLECULAR GENETICS
- Molecular Spectrum of Autosomal Dominant Hypercholesterolemia in France
- (2010) Marie Marduel et al. HUMAN MUTATION
- Molecular characterization of Polish patients with familial hypercholesterolemia: novel and recurrentLDLR mutations
- (2010) M. Chmara et al. JOURNAL OF APPLIED GENETICS
- Molecular Characterization of the NPC1L1 Variants Identified from Cholesterol Low Absorbers
- (2010) Li-Juan Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of Apolipoprotein B in the Kidney Attenuates Renal Lipid Accumulation
- (2010) Marcin Krzystanek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Bile Acid Synthesis by Fat-soluble Vitamins A and D
- (2010) Daniel R. Schmidt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Angiopoietin-like Protein 3 Inhibits Lipoprotein Lipase Activity through Enhancing Its Cleavage by Proprotein Convertases
- (2010) Jun Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin
- (2010) A. Wahe et al. JOURNAL OF CELL SCIENCE
- Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice
- (2010) Ralph Burkhardt et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic cholesterol transporterABCG8polymorphisms in gallstone disease in an Indian population
- (2010) Siva Prasad Siddapuram et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Clinical observations, molecular genetic analysis, and treatment of sitosterolemia in infants and children
- (2010) Dau-Ming Niu et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Gallstone disease in Swedish twins: risk is associated with ABCG8 D19H genotype
- (2010) D. Katsika et al. JOURNAL OF INTERNAL MEDICINE
- Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
- (2010) Roman Chrast et al. JOURNAL OF LIPID RESEARCH
- Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
- (2010) Jeffrey D. Browning et al. JOURNAL OF LIPID RESEARCH
- Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men
- (2010) André J. Tremblay et al. JOURNAL OF LIPID RESEARCH
- A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
- (2010) Yan G. Ni et al. JOURNAL OF LIPID RESEARCH
- Human luteinized granulosa cells secrete apoB100-containing lipoproteins
- (2010) Thomas Gautier et al. JOURNAL OF LIPID RESEARCH
- Malformation syndromes caused by disorders of cholesterol synthesis
- (2010) Forbes D. Porter et al. JOURNAL OF LIPID RESEARCH
- ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis
- (2010) Lily Jakulj et al. JOURNAL OF LIPID RESEARCH
- Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population
- (2010) Ilaria Guella et al. JOURNAL OF LIPID RESEARCH
- Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
- (2010) Bin Dong et al. JOURNAL OF LIPID RESEARCH
- High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
- (2010) Greg Welder et al. JOURNAL OF LIPID RESEARCH
- Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry
- (2010) I. Miljkovic et al. JOURNAL OF LIPID RESEARCH
- Structure of the Minimal Interface Between ApoE and LRP
- (2010) Miklos Guttman et al. JOURNAL OF MOLECULAR BIOLOGY
- Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches
- (2010) Anton I. Rosenbaum et al. JOURNAL OF NEUROCHEMISTRY
- PCSK9R46L, Low-Density Lipoprotein Cholesterol Levels, and Risk of Ischemic Heart Disease
- (2010) Marianne Benn et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Unknown
- (2010) Gie Ken-Dror et al. MOLECULAR MEDICINE
- From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
- (2010) Kiran Musunuru et al. NATURE
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin
- (2010) Fenghua Hu et al. NEURON
- Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia
- (2010) Kiran Musunuru et al. NEW ENGLAND JOURNAL OF MEDICINE
- The role of ezetimibe in the prevention of cardiovascular disease: Where do we stand after ARBITER 6-HALTS
- (2010) Wm.J. Howard NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers
- (2010) Noel Peretti et al. Orphanet Journal of Rare Diseases
- The effect of simvastatin on the proteome of detergent-resistant membrane domains: Decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate
- (2010) Jovita Ponce et al. PROTEOMICS
- A double heterozygote for familial hypercholesterolaemia and familial defective apolipoprotein B-100
- (2010) A. Taylor et al. ANNALS OF CLINICAL BIOCHEMISTRY
- APOE Genotype, Lipids, and Coronary Heart Disease Risk
- (2009) Heather Ward et al. ARCHIVES OF INTERNAL MEDICINE
- PCSK9 Dominant Negative Mutant Results in Increased LDL Catabolic Rate and Familial Hypobetalipoproteinemia
- (2009) Bertrand Cariou et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Proprotein Convertase Subtilisin Kexin Type 9 Null Mice Are Protected From Postprandial Triglyceridemia
- (2009) Cédric Le May et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Identification of Genetic Variants Associated With Response to Statin Therapy
- (2009) Jessica L. Mega et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Commentary PCSK9 variants: A new database
- (2009) Sarah E.A. Leigh et al. ATHEROSCLEROSIS
- Prevalence and clinical features of heterozygous carriers of autosomal recessive hypercholesterolemia in Sardinia
- (2009) Fabiana Filigheddu et al. ATHEROSCLEROSIS
- Familial hypobetalipoproteinemia due to apolipoprotein B R463W mutation causes intestinal fat accumulation and low postprandial lipemia
- (2009) Davide Noto et al. ATHEROSCLEROSIS
- Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
- (2009) Patrick Linsel-Nitschke et al. ATHEROSCLEROSIS
- Statins inhibit Akt/PKB signaling via P2X7 receptor in pancreatic cancer cells
- (2009) Oras Mistafa et al. BIOCHEMICAL PHARMACOLOGY
- The Role of Calcium in Lipoprotein Release by the Low-Density Lipoprotein Receptor
- (2009) Zhenze Zhao et al. BIOCHEMISTRY
- Decoding of Lipoprotein−Receptor Interactions: Properties of Ligand Binding Modules Governing Interactions with Apolipoprotein E
- (2009) Miklos Guttman et al. BIOCHEMISTRY
- Apolipoproteins A-I, A-II and E are independently distributed among intracellular and newly secreted HDL of human hepatoma cells
- (2009) Baiba K. Gillard et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
- (2009) Hyock Joo Kwon et al. CELL
- The Vps10p-domain receptor family
- (2009) Guido Hermey CELLULAR AND MOLECULAR LIFE SCIENCES
- Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K
- (2009) Yu Sun et al. CIRCULATION RESEARCH
- Longitudinal Association of PCSK9 Sequence Variations With Low-Density Lipoprotein Cholesterol Levels
- (2009) Chiang-Ching Huang et al. Circulation-Cardiovascular Genetics
- An apparent inconsistency in parent to offspring transmission of point mutations of LDLR gene in Familial Hypercholesterolemia
- (2009) Claudio Rabacchi et al. CLINICA CHIMICA ACTA
- Severe hyperthyroidism: aetiology, clinical features and treatment outcome
- (2009) P. Iglesias et al. CLINICAL ENDOCRINOLOGY
- Silent exonic mutations in the low-density lipoprotein receptor gene that cause familial hypercholesterolemia by affecting mRNA splicing
- (2009) JC Defesche et al. CLINICAL GENETICS
- Multiplex ligation-dependent probe amplification analysis to screen for deletions and duplications of theLDLRgene in patients with familial hypercholesterolaemia
- (2009) A Taylor et al. CLINICAL GENETICS
- Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project
- (2009) A Taylor et al. CLINICAL GENETICS
- Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer
- (2009) Peter JH Jones et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes
- (2009) Jibin Zeng et al. EXPERIMENTAL CELL RESEARCH
- The molecular basis of familial hypercholesterolemia in Lebanon: Spectrum ofLDLRmutations and role ofPCSK9as a modifier gene
- (2009) Marianne Abifadel et al. HUMAN MUTATION
- Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease
- (2009) Marianne Abifadel et al. HUMAN MUTATION
- A Unified Scheme for Initiation and Conformational Adaptation of Human Apolipoprotein E N-terminal Domain upon Lipoprotein Binding and for Receptor Binding Activity
- (2009) Arun Sivashanmugam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nonsynonymous Mutations withinAPOBin Human Familial Hypobetalipoproteinemia
- (2009) Shumei Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic and Metabolic Determinants of Plasma PCSK9 Levels
- (2009) Susan G. Lakoski et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- A Stretch of 17 Amino Acids in the Prosaposin C Terminus Is Critical for Its Binding to Sortilin and Targeting to Lysosomes
- (2009) Libin Yuan et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
- (2009) Jiang Wang et al. JOURNAL OF LIPID RESEARCH
- The National Niemann-Pick Type C1 Disease Database: correlation of lipid profiles, mutations, and biochemical phenotypes
- (2009) William S. Garver et al. JOURNAL OF LIPID RESEARCH
- VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation
- (2009) Sarada D. Tetali et al. JOURNAL OF LIPID RESEARCH
- Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor
- (2009) Sha Huang et al. JOURNAL OF LIPID RESEARCH
- HNF1α and SREBP2 are important regulators of NPC1L1 in human liver
- (2009) Camilla Pramfalk et al. JOURNAL OF LIPID RESEARCH
- Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly
- (2009) Eliana Polisecki et al. JOURNAL OF LIPID RESEARCH
- Bile acids: regulation of synthesis
- (2009) John Y. L. Chiang JOURNAL OF LIPID RESEARCH
- Genetic diagnosis of familial hypercholesterolaemia: the importance of functional analysis of potential splice-site mutations
- (2009) M Bourbon et al. JOURNAL OF MEDICAL GENETICS
- Large scale replication analysis of loci associated with lipid concentrations in a Japanese population
- (2009) K Nakayama et al. JOURNAL OF MEDICAL GENETICS
- Rapid constitutive and ligand-activated endocytic trafficking of P2X3receptor
- (2009) Fabrizio Vacca et al. JOURNAL OF NEUROCHEMISTRY
- Novel Missense Mutations of SAR1B Gene in an Infant With Chylomicron Retention Disease
- (2009) Suporn Treepongkaruna et al. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
- The Type of LDLR Gene Mutation Predicts Cardiovascular Risk in Children with Familial Hypercholesterolemia
- (2009) Ornella Guardamagna et al. JOURNAL OF PEDIATRICS
- Variable phenotypic expression of chylomicron retention disease in a kindred carrying a mutation of the Sara2 gene
- (2009) Angelo B. Cefalù et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Chylomicron retention disease: A long term study of two cohorts
- (2009) Noel Peretti et al. MOLECULAR GENETICS AND METABOLISM
- Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae
- (2009) E. E. Kenny et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Model of human low-density lipoprotein and bound receptor based on CryoEM
- (2009) G. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
- (2009) L. Abi-Mosleh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
- (2009) Noam Zelcer et al. SCIENCE
- Update and Analysis of the University College London Low Density Lipoprotein Receptor Familial Hypercholesterolemia Database
- (2008) S. E. A. Leigh et al. ANNALS OF HUMAN GENETICS
- Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13
- (2008) Ralph Burkhardt et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Absence of Hyperlipidemia in LDL Receptor-Deficient Mice Having Apolipoprotein B100 Without the Putative Receptor-Binding Sequences
- (2008) Lance A. Johnson et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice
- (2008) Michael Altenburg et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Relationship of the ApoE polymorphism to plasma lipid traits among South Asians, Chinese, and Europeans living in Canada
- (2008) Debika Burman et al. ATHEROSCLEROSIS
- Degradation of LDLR protein mediated by ‘gain of function’ PCSK9 mutants in normal and ARH cells
- (2008) Tommaso Fasano et al. ATHEROSCLEROSIS
- Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study†
- (2008) Yuko Yamauchi et al. BIOCHEMISTRY
- Significant association ofABCG5604Q andABCG8D19H polymorphisms with gallstone disease
- (2008) K.‐K. Kuo et al. BRITISH JOURNAL OF SURGERY
- Structural Basis for Cargo Regulation of COPII Coat Assembly
- (2008) Scott M. Stagg et al. CELL
- The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1
- (2008) Liang Ge et al. Cell Metabolism
- Genetic Loci Associated With Plasma Concentration of Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, Triglycerides, Apolipoprotein A1, and Apolipoprotein B Among 6382 White Women in Genome-Wide Analysis With Replication
- (2008) Daniel I. Chasman et al. Circulation-Cardiovascular Genetics
- Higher frequency of abnormal serum angiopoietin-like protein 3 than abnormal cholesteryl ester transfer protein in Japanese hyperalphalipoproteinemic subjects
- (2008) Hyun Duk Moon et al. CLINICA CHIMICA ACTA
- Identification of a novel mutation for phytosterolemia. Genetic analyses of 2 cases
- (2008) Masako Togo et al. CLINICA CHIMICA ACTA
- Identification of patients with abetalipoproteinemia and homozygous familial hypobetalipoproteinemia in Tunisia
- (2008) Mohamed Najah et al. CLINICA CHIMICA ACTA
- Hypocholesterolemia in adult patients with thalassemia: a link with the severity of genotype in thalassemia intermedia patients
- (2008) Paolo Ricchi et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules
- (2008) Arthur Kaser et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Identification of two novel mutations and long-term follow-up in abetalipoproteinemia: a report of four cases
- (2008) Laurence Chardon et al. EUROPEAN JOURNAL OF PEDIATRICS
- Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes
- (2008) Saleemah Fahmi et al. HUMAN MOLECULAR GENETICS
- APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels
- (2008) Kathy Klos et al. HUMAN MOLECULAR GENETICS
- Regulation of ApoB Secretion by the Low Density Lipoprotein Receptor Requires Exit from the Endoplasmic Reticulum and Interaction with ApoE or ApoB
- (2008) Daniel A. Blasiole et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microsomal Triglyceride Transfer Protein Enhances Cellular Cholesteryl Esterification by Relieving Product Inhibition
- (2008) Jahangir Iqbal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms
- (2008) Lu Shan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Charged Amino Acid Residues 997–1000 of Human Apolipoprotein B100 Are Critical for the Initiation of Lipoprotein Assembly and the Formation of a Stable Lipidated Primordial Particle in McA-RH7777 Cells
- (2008) Medha Manchekar et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and dynamic interfacial properties of the lipoprotein initiating domain of apolipoprotein B
- (2008) Aubrey S. Ledford et al. JOURNAL OF LIPID RESEARCH
- Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8
- (2008) Weiqing Tang et al. JOURNAL OF LIPID RESEARCH
- Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
- (2008) Philipp Wiesner et al. JOURNAL OF LIPID RESEARCH
- Functional analysis of sites within PCSK9 responsible for hypercholesterolemia
- (2008) Shilpa Pandit et al. JOURNAL OF LIPID RESEARCH
- PCSK9: a convertase that coordinates LDL catabolism
- (2008) Jay D. Horton et al. JOURNAL OF LIPID RESEARCH
- Frequency of Low-Density Lipoprotein Receptor Gene Mutations in Patients With a Clinical Diagnosis of Familial Combined Hyperlipidemia in a Clinical Setting
- (2008) Fernando Civeira et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Niemann-Pick C1-Like 1 Mediates -Tocopherol Transport
- (2008) K. Narushima et al. MOLECULAR PHARMACOLOGY
- Abetalipoproteinemia: two case reports and literature review
- (2008) Rola Zamel et al. Orphanet Journal of Rare Diseases
- Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
- (2008) Patrick Linsel-Nitschke et al. PLoS One
- Extracellular loop C of NPC1L1 is important for binding to ezetimibe
- (2008) A. B. Weinglass et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
- (2008) D.-W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
- (2008) Y. Urano et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High-resolution melting analysis for detection of familial ligand-defective apolipoprotein B-100 mutations
- (2008) Khemanganee E Liyanage et al. ANNALS OF CLINICAL BIOCHEMISTRY
- Femoral Atherosclerosis In Heterozygous Familial Hypercholesterolemia
- (2007) Mireia Junyent et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Familial hypercholesterolaemia in Portugal
- (2007) M. Bourbon et al. ATHEROSCLEROSIS
- AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes
- (2007) Maryssa Canuel et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Common and Rare Alleles in Apolipoprotein B Contribute to Plasma Levels of Low-Density Lipoprotein Cholesterol in the General Population
- (2007) Marianne Benn et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Anderson or chylomicron retention disease: Molecular impact of five mutations in the SAR1B gene on the structure and the functionality of Sar1b protein
- (2007) Mathilde Charcosset et al. MOLECULAR GENETICS AND METABOLISM
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search