Still another activity by the highly promiscuous enzyme CYP3A4: 25-hydroxylation of cholesterol: Fig. 1.

Inhibition of Human Cytochrome P450 3A4 by Cholesterol

(2011) Raku Shinkyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol 25-hydroxylation activity of CYP3A

(2011) Akira Honda et al.   JOURNAL OF LIPID RESEARCH

4β-hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans

(2010) Ulf Diczfalusy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide

(2009) Ulf Diczfalusy et al.   JOURNAL OF LIPID RESEARCH

25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production

(2009) D. R. Bauman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time course of the increase in 4β-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy

(2008) Katarina Wide et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY