Microdomains in the membrane landscape shape antigen-presenting cell function

Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells

(2013) Bo Yu et al.   BIOMATERIALS

Blueprints of Signaling Interactions between Pattern Recognition Receptors: Implications for the Design of Vaccine Adjuvants

(2013) Kim Timmermans et al.   Clinical and Vaccine Immunology

Multimolecular Signaling Complexes Enable Syk-Mediated Signaling of CD36 Internalization

(2013) Bryan Heit et al.   DEVELOPMENTAL CELL

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

Major Histocompatibility Complex (MHC) Class II-Peptide Complexes Arrive at the Plasma Membrane in Cholesterol-rich Microclusters

(2013) Berta Bosch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cavin1; a Regulator of Lung Function and Macrophage Phenotype

(2013) Praveen Govender et al.   PLoS One

Spatial partitioning improves the reliability of biochemical signaling

(2013) A. Mugler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caveolin-1 Plays a Critical Role in the Differentiation of Monocytes into Macrophages

(2012) Yi Fu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid rafts generate digital-like signal transduction in cell plasma membranes

(2012) Kenichi G. N. Suzuki   Biotechnology Journal

Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals

(2012) Rosa Lapalombella et al.   CANCER CELL

Molecular view on PRR cross-talk in antifungal immunity

(2012) S. Hontelez et al.   CELLULAR MICROBIOLOGY

The AC8 IgG3 monoclonal anti-cholesterol antibody modulates uptake and presentation of antigens for T cell activation

(2012) Emese Izsepi et al.   IMMUNOLOGY LETTERS

The Neck Region of the C-type Lectin DC-SIGN Regulates Its Surface Spatiotemporal Organization and Virus-binding Capacity on Antigen-presenting Cells

(2012) Carlo Manzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD151 restricts the  6 integrin diffusion mode

(2012) X. H. Yang et al.   JOURNAL OF CELL SCIENCE

Advances in high-resolution imaging - techniques for three-dimensional imaging of cellular structures

(2012) D. S. Lidke et al.   JOURNAL OF CELL SCIENCE

Dynamics within tetraspanin pairs affect MHC class II expression

(2012) T. van den Hoorn et al.   JOURNAL OF CELL SCIENCE

DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function

(2012) Eric A. Gurzell et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD81 regulates cell migration through its association with Rac GTPase

(2012) Emilio Tejera et al.   MOLECULAR BIOLOGY OF THE CELL

Lateral mobility of individual integrin nanoclusters orchestrates the onset for leukocyte adhesion

(2012) G. J. Bakker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoscale Membrane Organization: Where Biochemistry Meets Advanced Microscopy

(2011) Alessandra Cambi et al.   ACS Chemical Biology

MHC Class II and CD9 in Human Eosinophils Localize to Detergent-Resistant Membrane Microdomains

(2011) Praveen Akuthota et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dynamic Organizing Principles of the Plasma Membrane that Regulate Signal Transduction: Commemorating the Fortieth Anniversary of Singer and Nicolson's Fluid-Mosaic Model

(2011) Akihiro Kusumi et al.   Annual Review of Cell and Developmental Biology

STED Nanoscopy Reveals Molecular Details of Cholesterol- and Cytoskeleton-Modulated Lipid Interactions in Living Cells

(2011) V. Mueller et al.   BIOPHYSICAL JOURNAL

R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming

(2011) G. Singh et al.   BLOOD

Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function

(2011) Khuloud Jaqaman et al.   CELL

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

(2011) Bebhinn Treanor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Cofilin-Mediated F-Actin Severing Is Regulated by the Rap GTPase and Controls the Cytoskeletal Dynamics That Drive Lymphocyte Spreading and BCR Microcluster Formation

(2011) S. A. Freeman et al.   JOURNAL OF IMMUNOLOGY

n−3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

(2011) Saame Raza Shaikh et al.   MOLECULAR ASPECTS OF MEDICINE

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments

(2011) Akanksha Chaturvedi et al.   NATURE IMMUNOLOGY

Probing protein heterogeneity in the plasma membrane using PALM and pair correlation analysis

(2011) Prabuddha Sengupta et al.   NATURE METHODS

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Next-Generation Sequencing of a 40 Mb Linkage Interval Reveals TSPAN12 Mutations in Patients with Familial Exudative Vitreoretinopathy

(2010) Konstantinos Nikopoulos et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy

(2010) James A. Poulter et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A New Wave of Cellular Imaging

(2010) Derek Toomre et al.   Annual Review of Cell and Developmental Biology

Cholesterol Depletion Mimics the Effect of Cytoskeletal Destabilization on Membrane Dynamics of the Serotonin1A Receptor: A zFCS Study

(2010) Sourav Ganguly et al.   BIOPHYSICAL JOURNAL

Rituximab for the Treatment of Non-Hodgkinʼs Lymphoma and Chronic Lymphocytic Leukaemia

(2010) Fredrick Hagemeister   DRUGS

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Distinct MHC Class II Molecules Are Associated on the Dendritic Cell Surface in Cholesterol-dependent Membrane Microdomains

(2010) Sanjay Khandelwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

(2010) Mary E. Irwin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency

(2010) Menno C. van Zelm et al.   JOURNAL OF CLINICAL INVESTIGATION

A Complementary Role for the Tetraspanins CD37 and Tssc6 in Cellular Immunity

(2010) K. H. Gartlan et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids

(2010) S. J. Sahl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct mapping of nanoscale compositional connectivity on intact cell membranes

(2010) T. S. van Zanten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Effects of Fat and Fatty Acid Intake on Inflammatory and Immune Responses: A Critical Review

(2009) Claudio Galli et al.   ANNALS OF NUTRITION AND METABOLISM

A nanometer scale optical view on the compartmentalization of cell membranes

(2009) Thomas S. van Zanten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Rituximab inhibits B-cell receptor signaling

(2009) S. Kheirallah et al.   BLOOD

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

The C-type lectin DC-SIGN internalizes soluble antigens and HIV-1 virionsviaa clathrin-dependent mechanism

(2009) Alessandra Cambi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tetraspanin CD9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation

(2009) Mayumi Suzuki et al.   JOURNAL OF IMMUNOLOGY

The role of tetraspanins in the pathogenesis of infectious diseases

(2009) Annemiek B. van Spriel et al.   MICROBES AND INFECTION

Hotspots of GPI-anchored proteins and integrin nanoclusters function as nucleation sites for cell adhesion

(2009) T. S. van Zanten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Caught in the act: quantifying protein behaviour in living cells

(2009) Diane S. Lidke et al.   TRENDS IN CELL BIOLOGY

Fungal pattern-recognition receptors and tetraspanins: partners on antigen-presenting cells

(2009) Carl G. Figdor et al.   TRENDS IN IMMUNOLOGY

Both MHC Class II and its GPI-Anchored Form Undergo Hop Diffusion as Observed by Single-Molecule Tracking

(2008) Yasuhiro M. Umemura et al.   BIOPHYSICAL JOURNAL

GM1 Expression of Non-Hodgkin's Lymphoma Determines Susceptibility to Rituximab Treatment

(2008) C. Meyer zum Buschenfelde et al.   CANCER RESEARCH

Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC

(2008) Kuo-Ching Sheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The tetraspanin CD151 regulates cell morphology and intracellular signaling on laminin-511

(2008) Masashi Yamada et al.   FEBS Journal

Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo

(2008) Philip Meuleman et al.   HEPATOLOGY

Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse

(2008) Hae Won Sohn et al.   JOURNAL OF CELL BIOLOGY

Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms

(2008) Olga Barreiro et al.   JOURNAL OF CELL BIOLOGY

Single-molecule analysis of CD9 dynamics and partitioning reveals multiple modes of interaction in the tetraspanin web

(2008) Cedric Espenel et al.   JOURNAL OF CELL BIOLOGY

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Targeting of tetraspanin proteins — potential benefits and strategies

(2008) Martin E. Hemler   NATURE REVIEWS DRUG DISCOVERY