Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 90, Issue 5, Pages 1017-1026Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0910520
Keywords
hCG; immune tolerance; pregnancy; transplant
Categories
Funding
- Kulturstiftung Essen (Germany)
Ask authors/readers for more resources
hCG hormone is a naturally occurring, immune-modulating agent, which is highly expressed during pregnancy and causes improvements of some autoimmune diseases such as multiple sclerosis and Crohn's disease. Little is known about its immune-modulating effects. This study in MNCs of women who received hCG as preconditioning prior to IVF demonstrates that hCG increases anti-inflammatory IL-27 expression and reduces inflammatory IL-17 expression. In addition, we found increased IL-10 levels and elevated numbers of Tregs in peripheral blood of women after hCG application. Rejection of allogeneic skin grafts was delayed in female mice receiving hCG. We conclude that hCG may be useful for the induction of immune tolerance in solid organ transplantation. J. Leukoc. Biol. 90: 1017-1026; 2011.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available