Article
Biochemistry & Molecular Biology
Letizia Lombardelli, Federica Logiodice, Ornela Kullolli, Herman Haller, Chiara Agostinis, Roberta Bulla, Daniel Rukavina, Marie-Pierre Piccinni
Summary: The role of IL-35 in human pregnancy was investigated. It was found that human trophoblast cells produced IL-35 and could polarize T cells. Low concentrations of IL-35 not only did not suppress Th cell proliferation but also stimulated IL-4 and IL-10 production. IL-35 was crucial for the differentiation of IL-35+, IL-10+, IL-4+ Th2-type cells in successful pregnancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Yan Li, Feng Lan, Yiran Yang, Yingjie Xu, Yalin Chen, Xiaofeng Qin, Zhe Lv, Wei Wang, Sun Ying, Luo Zhang
Summary: This study investigated the role of IL-9 on ILC2 and Th2 cells in a murine model of asthma. The results showed that IL-9 promotes the proliferation and cytokine production of type 2 cells. This suggests that IL-9 may be a potential therapeutic target for asthma treatment.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Florian Sicklinger, Ingmar Soren Meyer, Xue Li, Daniel Radtke, Severin Dicks, Moritz P. Kornadt, Christina Mertens, Julia K. Meier, Kory J. Lavine, Yunhang Zhang, Tim Christian Kuhn, Tobias Terzer, Jyoti Patel, Melanie Boerries, Gabriele Schramm, Norbert Frey, Hugo A. Katus, David Voehringer, Florian Leuschner
Summary: The study show that basophils play a crucial role in promoting tissue repair after myocardial infarction by increasing levels of IL-4 and IL-13 in the heart. Depletion of basophils leads to an increase in inflammatory response, scar thinning, and deterioration of cardiac function post-MI.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Hematology
Johanna Melo-Cardenas, Lavanya Bezavada, Jeremy Chase Crawford, Sandeep Gurbuxani, Anitria Cotton, Guolian Kang, Jeffrey Gossett, Christian Marinaccio, Rona Weinberg, Ronald Hoffman, Anna Rita Migliaccio, Yan Zheng, Marta Derecka, Ciro R. Rinaldi, John D. Crispino
Summary: This study analyzed MF mouse models and samples from MF patients, and found that high levels of IL-13 are associated with MF progression and fibrosis. Inhibition of the IL-13/IL-4 signaling pathway may serve as a novel therapeutic target for treating MF.
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noemie Caillot, Fabien Colaone, Samir Hamdi, Raissa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, Francois Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurelie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Geraldine Grouard-Vogel, Laurent L. Reber
Summary: The study developed vaccines targeting IL-4 and IL-13, demonstrating promising prophylactic and therapeutic effects in mouse models of asthma. Vaccines specific for human IL-4 and IL-13 also showed efficient neutralization of these cytokines in mice, suggesting a potential long-term therapeutic strategy for allergic asthma.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Georgia Pappa, Dimitrios Sgouros, Konstantinos Theodoropoulos, Antonios Kanelleas, Evangelia Bozi, Stamatios Gregoriou, Konstantinos Krasagakis, Alexander C. Katoulis
Summary: Atopic dermatitis is a complex inflammatory skin disease with multiple underlying factors. Recent studies have highlighted the important roles of interleukins-4 and -13 in the pathogenesis of atopic dermatitis. Novel therapeutic approaches targeting Th2 cytokines and their pathways offer potential for optimizing the treatment of atopic dermatitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Sunil Tomar, Varsha Ganesan, Ankit Sharma, Chang Zeng, Lisa Waggoner, Andrew Smith, Chang H. Kim, Paula Licona-Limon, Richard L. Reinhardt, Richard A. Flavell, Yui-Hsi Wang, Simon P. Hogan
Summary: This study found that IL-4Ra signaling directly modulates MMC9 function and exacerbates experimental IgE-mediated food allergic reactions. IL-4Ra regulation of MMC9s is partly BATF-dependent and occurs via modulation of metabolic transcriptional programs.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Masato Kubo
Summary: IL-4 is a key regulatory cytokine secreted by T(H)2 and T-FH cells, playing a crucial role in humoral immune responses, particularly in B-cell help and antibody formation processes.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Hyeong Rok Yun, Sang Woo Ahn, Bomin Seol, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han, Kyung Soo Ko, Byoung Doo Rhee, Jung Eun Seol, Hyoung Kyu Kim
Summary: The study demonstrated the anti-inflammatory effects of Echinochrome A (Ech A) extracted from sea urchins in alleviating atopic dermatitis (AD) like skin lesions in an NC/Nga mouse model. Ech A treatment improved clinical symptoms of AD, reduced water loss, enhanced stratum corneum hydration, and suppressed inflammatory response and cytokine expression in skin lesions.
Review
Immunology
Celina Dubin, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis is a common inflammatory skin disease with a complex pathophysiology involving immune dysregulation and barrier defects. The IL-4, IL-13, and IL-31 pathways play key roles in the disease's pathogenesis, and novel therapeutics targeting these pathways are being developed for potential treatments.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Chun Yang, Jianhong Lin, Hongyan Liang, Li Xue, Ariel Kwart, Meng Jiang, Jianjun Zhao, Huan Ren, Xiaofeng Jiang, Nikhil C. Munshi
Summary: The CD44 v5 domain plays a crucial role in Th2 cell differentiation by interfering with the interaction between CD44 v5 domain and IL-4R alpha, leading to accelerated degradation of IL-4R alpha and subsequent inhibition of Th2 cells. Blocking or ablating the CD44 v5 domain could disrupt this process.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guodong Cai, Shuangshuang Liu, Fang Zhong, Jianhong Gu, Yan Yuan, JiaQiao Zhu, Guoqiang Zhu, Zongping Liu, Hui Zou, Jianchun Bian
Summary: The study revealed that ZEA, DON, and ZEA + DON exacerbate spleen damage and inhibit Th2 cell differentiation after Listeria infection. These toxins suppress the differentiation of Th2 cells by affecting the synthesis of IL-4R in CD4+ T cells, indicating impaired immune response to pathogens after mycotoxin poisoning.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Na Song, Jae-Won Lee, Hyung Won Ryu, Jae Kyoung Lee, Eun Sol Oh, Doo-Young Kim, Hyunju Ro, Dahye Yoon, Ji-Yoon Park, Sung-Tae Hong, Mun-Ock Kim, Su Ui Lee, Dae Young Lee
Summary: Black ginseng extract (BGE) has preventive effects on respiratory inflammatory diseases such as asthma by inhibiting cytokine production and the activation of protein kinase C theta (PKC?) and its downstream signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mengdie Li, Fengrun Sun, Jinfeng Qian, Lanting Chen, Dajin Li, Songcun Wang, Meirong Du
Summary: Establishing maternal-fetal tolerance and successful placentation are crucial for a successful pregnancy, as disruption of immune balance and inadequate placental perfusion can lead to pregnancy-related complications. Extravillous trophoblasts play a key role in regulating decidual immune cells for fetal tolerance. Blocking Tim-3 and CTLA-4 pathways can lead to abnormal interaction between decidual immune cells and extravillous trophoblasts, resulting in poor placental development and increased fetal loss. IL-4 and IL-10 treatment may rescue the adverse effects of targeting Tim-3 and CTLA-4 on pregnancy outcomes, suggesting them as potential therapeutic strategies to prevent pregnancy loss induced by checkpoint inhibition.
Article
Gastroenterology & Hepatology
Yoon Seok Choi, Min Kyung Jung, Jeewon Lee, Seong Jin Choi, Sung Hoon Choi, Hyun Woong Lee, Jong-Joo Lee, Hyung Joon Kim, Sang Hoon Ahn, Dong Hyeon Lee, Won Kim, Su-Hyung Park, Jun R. Huh, Hyoung-Pyo Kim, Jun Yong Park, Eui-Cheol Shin
Article
Dermatology
Tae-Gyun Kim, Sung Hee Kim, Jeyun Park, Wanho Choi, Moah Sohn, Hye Young Na, Minseok Lee, Jae Won Lee, Soo Min Kim, Do-Young Kim, Hyoung-Pyo Kim, Jae-Noon Choi, Chae Gyu Park, Min-Geol Lee
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Cell Biology
Eun-Seok Choi, Hanna Lee, Jee Young Sung, Chang-Hun Lee, Hyonchol Jang, Kyung Tae Kim, Yong-Nyun Kim, Hyoung-Pyo Kim, Sung-Ho Goh
CELL DEATH & DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Ji-Hyun Ma, Hyoung-Pyo Kim, Jinwoong Bok, Jeong-Oh Shin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Dasom Son, Hyun-Kyung Kong, Yesol Kim, Min-Ji Song, Hyong Pyo Kim, Han Woong Lee, Jong Hoon Park
Article
Biochemistry & Molecular Biology
Ji-Hyun Ma, Hyoung-Pyo Kim, Jeong-Oh Shin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Nawapol Kunkeaw, Yeon-Su Lee, Wonkyun Ronny Im, Jiyoung Joan Jang, Min-Ji Song, Bobae Yang, Jong-Lyul Park, Seon-Young Kim, Yongsuk Ku, Yoosik Kim, Sangmin Kang, Hye-ram Jo, Jae-Hoon Jeong, Hyun-Sung Lee, Ju-Seog Lee, Hyoung-Pyo Kim, Betty H. Johnson, In-Hoo Kim, Yong Sun Lee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Chul Min Yang, Moo-Koo Kang, Woong-Jae Jung, Jung-Sik Joo, Yong-Jin Kim, Yeeun Choi, Hyoung-Pyo Kim
Summary: p53, a critical tumor suppressor protein, influences drug sensitivity in a transcription-independent manner by regulating chromatin accessibility of genes associated with cell apoptosis. Treatment with 5-FU leads to global increases in chromatin accessibility, with chromatin organization in specific genomic regions being influenced by p53 expression status.
Article
Biochemistry & Molecular Biology
Ryanggeun Lee, Moo-Koo Kang, Yong-Jin Kim, Bobae Yang, Hwanyong Shim, Sugyung Kim, Kyungwoo Kim, Chul Min Yang, Byeong-gyu Min, Woong-Jae Jung, Eun-Chong Lee, Jung-Sik Joo, Gunhee Park, Won-Ki Cho, Hyoung-Pyo Kim
Summary: CTCF plays a crucial role in RNA polymerase II (Pol II)-mediated chromatin interactions at super-enhancers, forming spatial clusters. CTCF clustering is resistant to liquid-liquid phase separation and has a significant instructive function in the formation of transcriptional condensates. Furthermore, depletion and restoration of CTCF affect the dissolution and reinstatement of Pol II, BRD4, and MED1 clusters, indicating the importance of CTCF in higher-order chromatin organization.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell & Tissue Engineering
Hyoeun Kim, Hyeong-Jin Kim, Jaewon Oh, Seung-Tae Lee, Dongju Won, Hyo-Kyoung Choi, Jong Rak Choi, Sangwoo Kim, Hyoung-Pyo Kim, Seok-Jun Kim, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: In this study, we reprogrammed PBMCs from a HCM patient into iPSCs carrying a heterozygous ACTA1 mutation. The generated iPSCs exhibited pluripotency and differentiation potential. This cell line serves as a valuable tool for investigating the pathogenesis of HCM.
STEM CELL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Sae-Bom Jeon, Hyoeun Kim, Kyeong-Hyeon Chun, Jaewon Oh, Chulan Kwon, Hyo-Kyoung Choi, Sangwoo Kim, Hyoung-Pyo Kim, In-Cheol Kim, Jung-Yoon Yoo, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: TNNT2 gene with p. Arg205Trp mutation is strongly linked to dilated cardiomyopathy (DCM). A human induced pluripotent stem cell (hiPSC) line, YCMi007-A, was generated from a DCM patient and showed high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Therefore, YCMi007-A could be a valuable tool for investigating DCM.
STEM CELL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Bobae Yang, Sueun Kim, Woong-Jae Jung, Kyungwoo Kim, Sugyung Kim, Yong-Jin Kim, Tae-Gyun Kim, Eun-Chong Lee, Jung-Sik Joo, Chae Gyu Park, Sumin Oh, Kyung Hyun Yoo, Hyoung-Pyo Kim
Summary: This study demonstrates that activation of bone marrow-derived dendritic cells induces extensive reprogramming of chromatin looping and enhancer activity, which are both implicated in the dynamic changes in gene expression. Depletion of CTCF attenuates GM-CSF-mediated JAK2/STAT5 signaling, resulting in defective NF-kappa B activation. Moreover, CTCF is necessary for establishing NF-kappa B-dependent chromatin interactions and maximal expression of pro-inflammatory cytokines.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yun Ji Jung, Yeji Lee, Hayan Kwon, Hyoung-Pyo Kim, Han-Sung Kwon, Eunhyang Park, JoonHo Lee, Young-Han Kim, Yong-Sun Maeng, Ja-Young Kwon
Summary: In pre-eclampsia, decidual lymphatic endothelial cells (dLECs) induce the polarization of decidual macrophages into the proinflammatory M1 phenotype through the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) via the NF-κB-dependent pathway.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Oncology
Hyehyun Min, Hyoung-Pyo Kim, Jeong-Oh Shin
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jeong-Oh Shin, Jong-Joo Lee, Mikyoung Kim, Youn Wook Chung, Hyehyun Min, Jae-Yoon Kim, Hyoung-Pyo Kim, Jinwoong Bok
MOLECULES AND CELLS
(2018)