A novel MEK2/PI3Kδ pathway controls the expression of IL-1 receptor antagonist in IFN-β-activated human monocytes

Toll-Like Receptor-Mediated Production of IL-1Ra Is Negatively Regulated by GSK3 via the MAPK ERK1/2

(2014) K. Rehani et al.   JOURNAL OF IMMUNOLOGY

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways

(2011) Jose R. Bayascas   CELL CYCLE

Akt and mRNA translation by interferons

(2010) Surinder Kaur et al.   CELL CYCLE

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration

(2010) Catherine Qiurong Pan et al.   JOURNAL OF CELL SCIENCE

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

(2010) Alex Berndt et al.   Nature Chemical Biology

Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2

(2010) Hao Zhang et al.   VIRUS RESEARCH

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

(2009) Boon Chua et al.   Molecular Cancer

A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal

(2009) Federica Catalanotti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1  in human monocytes and multiple sclerosis

(2009) D. Burger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAP kinase: It’s been longer than fifteen minutes

(2008) Thomas W. Sturgill   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

(2008) Laure Voisin et al.   BMC CANCER

Induction of serum soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin-1 receptor antagonist (IL-1ra) by interferon beta-1b in patients with progressive multiple sclerosis

(2008) M. Comabella et al.   JOURNAL OF NEUROLOGY

Differential regulation of cytokine production by PI3Kδ in human monocytes upon acute and chronic inflammatory conditions

(2008) Nicolas Molnarfi et al.   MOLECULAR IMMUNOLOGY

MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments

(2007) Ellen Skarpen et al.   FASEB JOURNAL