Review
Immunology
Mario Riera Romo
Summary: Regulated or programmed cell death is crucial for development, tissue organization, and immunity. Advancements in cellular and molecular research have expanded the understanding of various cell death modalities and their biochemical programs. Recent evidence points to the interconnectedness of cell death pathways and their roles in immune mechanisms.
Article
Chemistry, Multidisciplinary
Huizhe Wang, Xiaohui Xiong, Jiaqi Zhang, Meicen Wu, Yinhui Gu, Yanli Chen, Yueqing Gu, Peng Wang
Summary: This study found that CycNHOH NPs and CypNHOH NPs can activate innate immunity by accelerating the DNA damage process through phototherapy and releasing immunogenic cell death, providing a new direction for the development of photo-immunotherapy.
Review
Biochemistry & Molecular Biology
Abigail M. Shotland, Andrew P. Fontenot, Amy S. McKee
Summary: Our understanding of regulated-cell-death pathways has expanded in recent decades, including a diverse spectrum of pathways besides apoptosis and primary necrosis. Airway macrophages play a critical role in maintaining airway functionality and may induce various RCD pathways when exposed to pathogenic organisms or particles. These pathways trigger immune responses, offering protection against pathogens while potentially contributing to lung injury and pathogenic immune responses.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Matthaios Sertedakis, Konstantinos Kotsaridis, Dimitra Tsakiri, Glykeria Mermigka, Ana Dominguez-Ferreras, Vardis Ntoukakis, Panagiotis F. Sarris
Summary: The study investigated putative virulence proteins from different Xylella fastidiosa subspecies and their ability to activate defense in Nicotiana model plants. Various Xf proteins induced cell death-like phenotypes in different Nicotiana species, categorized based on enzymatic groups. Additionally, similar proteins were found to elicit varying cell death responses in different cultivars of the same plant species, providing insights into host defense activation and pathogen adaptation mechanisms.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Wang, Jing Xiong, Diwei Zhou, Shanfeng Zhang, Li Wang, Qingqing Tian, Changming Li, Jie Liu, Yaping Wu, Junying Li, Jun Wang
Summary: This study uncovered the role of TRIM34 in regulating IAV-induced programmed cell death by mediating the K63-linked polyubiquitination of ZBP1. The interaction between TRIM34 and ZBP1 protected mice from inflammatory responses and epithelial damage during IAV infection. Higher levels of ZBP1 were found to correlate with increased proinflammatory cytokines in IAV-infected patients.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Thibault Rosazza, Jordan Warner, Gabriel Sollberger
Summary: Cell death is a crucial part of infectious and sterile inflammatory reactions, with neutrophil extracellular traps (NETs) being a special form of lytic cell death. Recent research shows significant crosstalk between different cell death pathways, particularly apoptosis, pyroptosis, and necroptosis.
Article
Biochemistry & Molecular Biology
Anukriti Mathur, Callum Kay, Yansong Xue, Abhimanu Pandey, Jiwon Lee, Weidong Jing, Daniel Enosi Tuipulotu, Jordan Lo Pilato, Shouya Feng, Chinh Ngo, Anyang Zhao, Cheng Shen, Melanie Rug, Lisa A. Miosge, Ines I. Atmosukarto, Jason D. Price, Sidra A. Ali, Elizabeth E. Gardiner, Avril A. B. Robertson, Milena M. Awad, Dena Lyras, Nadeem O. Kaakoush, Si Ming Man
Summary: Two virulence factors, lecithinase and perfringolysin O, from the human bacterial pathogen Clostridium perfringens, activate the NLRP3 inflammasome in mice and humans, inducing inflammation and cell death. Lecithinase enters vesicular structures and induces lysosomal membrane destabilization, leading to the release of inflammatory cytokines IL-1β and IL-18.
Article
Fisheries
Yu Chen, Mengjing Zhao, Xiongwei Fan, Ping Zhu, Zhaobiao Jiang, Faxiang Li, Wuzhou Yuan, Shiqi You, Jimei Chen, Yunxuan Li, Yan Shi, Xiaolan Zhu, Xiangli Ye, Fang Li, Jian Zhuang, Yongqing Li, Zhigang Jiang, Yuequn Wang, Xiushan Wu
Summary: The expression of gcFKBP5 in the primary innate immune organs of grass carp was highly upregulated by SVCV within 24 hours, as well as in fish cells treated with poly(I:C). Overexpression of gcFKBP aggravated viral damage to cells and increased viral replication. Additionally, SVCV interacts with gcFKBP5 and TRAF2 to promote host cell apoptosis for supporting viral replication.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Microbiology
Yuki Shundo, Rintaro On, Takemasa Matsumoto, Hiroshi Ouchi, Masaki Fujita
Summary: This study investigated the role of apoptosis in mouse models of M. avium infection. The results showed that TNFR1-KO mice were more susceptible to M. avium infection compared to TNFR2-KO and wild-type mice. The induction of apoptosis played an important role in innate immunity against M. avium in mice.
Article
Fisheries
K. P. Madushani, K. A. S. N. Shanaka, H. M. S. M. Wijerathna, Chaehyeon Lim, Taehyug Jeong, Sumi Jung, Jehee Lee
Summary: In this study, Bcl2 in Amphiprion clarkii was identified as an anti-apoptotic protein with the highest expression level in blood, potentially facilitating the propagation of viral infections.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhi-Chao Hu, Ben Wang, Xiao-Gang Zhou, Hai-Feng Liang, Bing Liang, Hong-Wei Lu, Yu-Xiang Ge, Qing Chen, Qi-Wei Tian, Feng-Feng Xue, Li-Bo Jiang, Jian Dong
Summary: This study developed a Golgi apparatus-targeted photodynamic strategy to activate NLRP3 and found that it promoted the release of proinflammatory contents, enhancing innate immunity and tumor immunogenicity. Pyroptosis led to immunogenic cell death, promoted dendritic cell maturation, and effectively activated antitumor immunity and long-lived immune memory.
Article
Fisheries
Yankai Wang, Jing Diao, Bei Wang, Xi Xu, Minjie Gui, Chenghua Li, Ming Guo
Summary: In this study, the second FADD gene in sea cucumber Apostichopus japonicus (AjFADD-2) was cloned and its potential function in innate responses was analyzed. It was found that AjFADD-2 was significantly induced in response to pathogen challenge and played a positive role in regulating apoptosis in coelomocytes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Oncology
Xiuting Liu, Graham D. Hogg, David G. DeNardo
Summary: The success of checkpoint inhibitors in cancer treatment has highlighted the importance of the immune system, particularly in eliciting antitumor responses. While initially thought to primarily target T cells, recent research suggests that these inhibitors may also impact innate immunity, thus playing a significant role in clinical efficacy. Further investigation into the mechanisms of action of checkpoint therapies on innate antitumor responses is crucial for developing effective combination treatments to combat checkpoint resistance in refractory malignancies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Corinne Clave, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Lea Ibaelosa, Benoit Pinson, Russell E. Vance, Sven J. Saupe, Asen Daskalov
Summary: Gasdermins are a family of proteins that control cell death reactions in both mammals and fungi. This study reveals the proteolytic regulation of Gasdermins in fungi, showing an evolutionary parallel between fungal and mammalian cell death pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
