Article
Biochemistry & Molecular Biology
Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi
Summary: Research suggests that CEACAM1 can regulate mature B cell activation mediated by BCR, playing an important role in immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Markus Lechner, Thomas Engleitner, Tea Babushku, Marc Schmidt-Supprian, Roland Rad, Lothar J. Strobl, Ursula Zimber-Strobl
Summary: FoB and MZB cells are functionally distinct mature B cell populations in the spleen, which can be re-programmed through Notch2 activation. The study demonstrates plasticity between these cell types and suggests a potential pathway for MZB cell development in vivo, driven by a singular signaling event.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Laura Quotti Tubi, Elisa Mandato, Sara Canovas Nunes, Arash Arjomand, Fortunato Zaffino, Sabrina Manni, Alessandro Casellato, Paolo Macaccaro, Nicola Vitulo, Sara Zumerle, Odile Filhol, Brigitte Boldyreff, Christian W. Siebel, Antonella Viola, Giorgio Valle, Federica Mainoldi, Stefano Casola, Valeria Cancila, Alessandro Gulino, Claudio Tripodo, Marco Pizzi, Angelo Paolo Dei Tos, Livio Trentin, Gianpietro Semenzato, Francesco Piazza
Summary: The role of CK2 in B-cell development and activation is not well understood. Using a CK2 beta(KO) mouse model, we found that CK2 beta(KO) mice exhibit increased marginal zone (MZ) B cells and reduced follicular B cells, suggesting a role for CK2 in the regulation of BCR and NOTCH2 signaling pathways. Further analysis revealed enhanced activation of the NOTCH2 pathway in CK2 beta(KO) mice, supporting MZ B-cell development. Additionally, CK2 beta(KO) mice showed alterations in immune response and B-cell activation processes. In vitro assays demonstrated impaired signaling downstream of BCR, Toll-like receptor, CD40, and IL-4R in B cells lacking CK2 beta.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lu Yang, Na Li, Di Yang, Anwei Chen, Jianlong Tang, Yukai Jing, Danqing Kang, Panpan Jiang, Xin Dai, Li Luo, Qiuyue Chen, Jiang Chang, Ju Liu, Heng Gu, Yanmei Huang, Qianglin Chen, Zhenzhen Li, Yingzi Zhu, Heather Miller, Yan Chen, Liru Qiu, Heng Mei, Yu Hu, Quan Gong, Chaohong Liu
Summary: The study revealed that deficiency of CCL2 enhances BCR signaling, leading to reduced marginal zone B cells and increased germinal center B cells, which can be rescued by mTORC1 inhibition. Additionally, CCL2 deficiency also promotes early activation of B cells.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Yongguang Zhang, Dongya Cui, Miaohui Huang, Yongwei Zheng, Baijiao Zheng, Liling Chen, Qi Chen
Summary: The protein NONO is a multifunctional nuclear protein that regulates transcriptional regulation, mRNA splicing, and DNA repair. This study shows that NONO has a critical role in B-cell development and B-cell activation. Deletion of NONO impairs early B-cell development and B-cell maturation, as well as the activation of pathways involved in B-cell activation, such as ERK, AKT, and NF-kappa B.
Article
Immunology
Kristina Ottens, Anne B. Satterthwaite
Summary: Strict control of B lymphocyte development is crucial for mounting immune responses effectively while maintaining self-tolerance.One of the key transcription factors, IRF4, plays a significant role in regulating different developmental stages and subtypes of B cells. Its unique functions range from limiting marginal zone B cell development to promoting plasma cell differentiation, highlighting its dominant role in early B lymphopoiesis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Artur Kibler, Bettina Budeus, Ralf Kueppers, Marc Seifert
Summary: The composition of human splenic marginal zone (sMZ) B cells changes significantly with age, with a major population of lowly Ig-mutated CD27neg but antigen-experienced B cells early in life.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daniel Michaud, Bhalchandra Mirlekar, Colleen Steward, Gail Bishop, Yuliya Pylayeva-Gupta
Summary: B cells can suppress anti-tumor T cell immunity in pancreatic cancer through the expression of IL-35. The synergy between BCR and TLR4 signaling pathways induces IL-35 expression in B cells. B cell receptor activation, rather than MyD88 signaling, is crucial for B cell-mediated suppression and promotion of pancreatic cancer growth. PKD2 is identified as a key downstream regulator of IL-35 expression in B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Anna-Karin E. Palm, Sandra Kleinau
Summary: Marginal zone (MZ) B cells are a subset of innate-like B cells mainly found in the spleen, participating in quick responses to blood-borne pathogens and secreting natural antibodies. While typically non-pathogenic, they may contribute to breaking immunological tolerance under specific stimuli.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Immunology
Timothy C. Borbet, Marcus J. Hines, Sergei B. Koralov
Summary: B lymphocytes play a central role in host immune defense, and their development and function are regulated by miRNAs. Studies have found that miRNAs are crucial for B cell development in the bone marrow and their subsequent population of the peripheral immune system, preventing autoimmunity by regulating downstream signaling of the B cell antigen receptor.
IMMUNOLOGICAL REVIEWS
(2021)
Article
Cell Biology
Andrea Harzschel, Lixia Li, Peter W. Krenn, Eva Szenes-Nagy, Geoffroy Andrieux, Elisabeth Bayer, Dietmar Pfeifer, Laura Polcik, Ursula Denk, Jan P. Hopner, Elif Karabatak, Danielle-Justine Danner, Simone Tangermann, Lukas Kenner, Hassan Jumaa, Richard Greil, Melanie Borries, Raphael Ruppert, Palash C. Maity, Tanja Nicole Hartmann
Summary: The lack of Kindlin-3 leads to a reduction in the number of B cells, especially late immature, mature, and recirculating B cells in the bone marrow, as well as a decrease in marginal zone B cells and an increase in follicular B cells in the spleen.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Cell Biology
Eirini Sevdali, Violeta Block, Marie Lataretu, Huiying Li, Cristian R. Smulski, Jana-Susann Briem, Yannic Heitz, Beate Fischer, Neftali-Jose Ramirez, Bodo Grimbacher, Hans-Martin Jack, Reinhard E. Voll, Martin Holzer, Pascal Schneider, Hermann Eibel
Summary: The binding of BAFF to BAFFR activates PI3K/AKT signaling in mature B cells, regulating protein synthesis, metabolic fitness, and survival. While both naive and memory B cells express the same levels of BAFFR, only memory B cells can survive without BAFF. BAFF activates PI3K/AKT specifically in naive B cells and affects the expression of genes involved in migration, proliferation, growth, and survival. The activation of PI3K/AKT by BAFF requires direct interactions between BAFFR and BCR components CD79A and CD79B, and is enhanced by the AKT coactivator TCL1A. Compared to memory B cells, naive B cells have more surface BCRs that interact better with BAFFR, allowing stronger responses to BAFF. BAFFR also acts as an intrinsic factor for B cell survival as its ablation in both naive and memory B cells leads to cell death independent of BAFF-induced signaling.
Article
Medicine, Research & Experimental
Brian T. Gaudette, Carly J. Roman, Trini A. Ochoa, Daniela Gomez Atria, Derek D. Jones, Christian W. Siebel, Ivan Maillard, David Allman
Summary: Little is known about how cells regulate and integrate distinct biosynthetic pathways governing differentiation and cell division. For B lineage cells it is widely accepted that activated cells must complete several rounds of mitosis before yielding antibody-secreting plasma cells. However, we report that marginal zone (MZ) B cells, innate-like naive B cells known to generate plasma cells rapidly in response to blood-borne bacteria, generate functional plasma cells despite cell-cycle arrest. Further, short-term Notch2 blockade in vivo reversed division-independent differentiation potential and decreased transcript abundance for numerous mTORC1-and Myc-regulated genes. Myc loss compromised plasma cell differentiation for MZ B cells, and reciprocally induced ectopic mTORC1 signaling in follicular B cells enabled division-independent differentiation and plasma cell-affiliated gene expression. We conclude that ongoing in situ Notch2/mTORC1 signaling in MZ B cells establishes a unique cellular state that enables rapid division-independent plasma cell differentiation.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cell Biology
Anwen Ren, Jianxuan Sun, Wei Yin, Lisa S. Westerberg, Heather Miller, Pamela Lee, Fabio Candotti, Fei Guan, Jiahui Lei, Quan Gong, Yan Chen, Chaohong Liu
Summary: B cells play a crucial role in humoral immune responses, with ongoing research into their development and signaling pathways offering new possibilities for disease treatment.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Li-Wen Lo, Chia-Wei Chang, Ming-Feng Chiang, I-Ying Lin, Kuo- Lin
Summary: Recent studies have shown that MZ B cells play a crucial role in regulating neutrophil migration in the spleen during systemic S. aureus infection, contributing to pathogen clearance. The upregulation of IL-6 and CXCL1/CXCL2 in MZ B cells post-infection promotes neutrophil recruitment. Interaction between neutrophils and MZ B cells is pivotal for IgM-secreting cell differentiation and overall immune response.
FRONTIERS IN IMMUNOLOGY
(2021)