Article
Biochemistry & Molecular Biology
D. S. Albrecht, M. Kim, O. Akeju, A. Torrado-Carvajal, R. R. Edwards, Y. Zhang, C. Bergan, E. Protsenko, A. Kucyi, A. D. Wasan, J. M. Hooker, V Napadow, M. L. Loggia
Summary: This study found that negative affect in chronic pain patients is associated with elevated levels of the glial marker TSPO in the brain and changes in functional connectivity.
MOLECULAR PSYCHIATRY
(2021)
Article
Anesthesiology
Debora M. Hofer, Thomas Lehmann, Ruth Zaslansky, Michael Harnik, Winfried Meissner, Frank Stueber, Ulrike M. Stamer
Summary: This study investigated the incidence of Chronic Postsurgical Pain (CPSP) by combining pain intensity and pain-related interference with function in patient-reported outcomes (PROs). A more comprehensive assessment of pain and interference resulted in lower CPSP rates than previously reported.
Article
Psychology, Multidisciplinary
Giacomo Rossettini, Andrea Colombi, Elisa Carlino, Mattia Manoni, Mattia Mirandola, Andrea Polli, Eleonora Maria Camerone, Marco Testa
Summary: This Perspective applies the validated ViolEx Model to the recovery and maintenance of musculoskeletal pain, exploring the reasons behind the persistence of dysfunctional expectations and the perspective of Bayesian Brain. The importance of tailoring clinical strategies based on the nature and precision of expectations is emphasized.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Qiu-Qin Han, Yi Fu, Jia-Mei Le, Yu-Jie Ma, Xin-Dong Wei, Hou-Lin Ji, Haochen Jiang, Yueqiu Gao, Hailong Wu
Summary: Acupuncture and electroacupuncture have been proven beneficial for cancer patients in alleviating symptoms, reducing treatment-related side-effects, and relieving pain. Further research is needed to clarify the potential mechanisms behind their clinical application.
Article
Geriatrics & Gerontology
Christina M. Marini, Stephanie J. Wilson, Ashley M. Tate, Lynn M. Martire, Melissa M. Franks
Summary: The study found that the visibility of support plays a moderating role in the association between spousal instrumental support provision and negative affect, with spouses reporting higher levels of negative affect when their support is not recognized by patients.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2021)
Article
Neurosciences
Sarina J. Iwabuchi, Marianne M. Drabek, William J. Cottam, Arman Tadjibaev, Ali-Reza Mohammadi-Nejad, Stamatios Sotiropoulos, Gwen S. Fernandes, Ana M. Valdes, Weiya Zhang, Michael Doherty, David A. Walsh, Dorothee P. Auer
Summary: This study investigated the relationship between mediodorsal thalamic circuitry, negative affect, and pain severity in chronic musculoskeletal pain. The findings demonstrate altered functional connectivity of the mediodorsal thalamus with brain regions linked to mood disorders in chronic pain patients. Additionally, the burden of pain appears to enhance the affect sensitivity of mediodorsal thalamic functional connectivity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Anesthesiology
Megan E. McPhee, Thomas Graven-Nielsen
Summary: This study examines the influence of attentional and affective manipulation on conditioned pain modulation among patients with low back pain. The results suggest that attention and positive affect can alleviate the perception of conditioned pain, and patients with recurrent low back pain exhibit less shift in valence during affective processing.
Review
Psychology, Multidisciplinary
Ferozkhan Jadhakhan, Raghip Sobeih, Deborah Falla
Summary: This systematic review found that physical activity interventions/exercise can reduce kinesiophobia in patients with chronic non-specific spine-related pain, especially Pilates and strengthening training programs.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Zoe Zambelli, Elizabeth J. Halstead, Antonio R. Fidalgo, Dagmara Dimitriou
Summary: Individuals with chronic pain often experience co-existing sleep problems and depression-related states. Chronic pain, sleep problems, and depression interrelate, and have been shown to exacerbate one another, which negatively impacts quality of life. The study found that sleep quality may moderate the relationship between pain interference and depression among individuals with chronic pain.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Anesthesiology
Dana Vertsberger, Anat Talmon, Maisa Ziadni, Jiang-Ti Kong, Beth D. Darnall, Rachel Manber, Sean Mackey, James J. Gross
Summary: Chronic low back pain has a negative impact on daily functioning, and the study found that pain coping strategies can moderate this impact. Pain rumination strengthens the link between pain intensity and interference, while pain reappraisal and distraction weaken it.
Article
Cell Biology
Qiansen Zhang, Yimin Ren, Yiqing Mo, Peipei Guo, Ping Liao, Yuncheng Luo, Jie Mu, Zhuo Chen, Yang Zhang, Ya Li, Linghui Yang, Daqing Liao, Jie Fu, Juwen Shen, Wei Huang, Xuewen Xu, Yanyan Guo, Lianghe Mei, Yunxia Zuo, Jin Liu, Huaiyu Yang, Ruotian Jiang
Summary: This study discovered the expression of neuronal Hv1 in peripheral sensory neurons and found that its up-regulation is associated with aggravated inflammation and nociception. Inhibiting neuronal Hv1 can reduce inflammatory pain and morphine-induced hyperalgesia and tolerance.
Article
Neurosciences
Marta Ceko, Philip A. Kragel, Choong-Wan Woo, Marina Lopez-Sola, Tor D. Wager
Summary: This study combines functional magnetic resonance imaging and predictive modeling to investigate the representations of generalized and stimulus-type-specific negative affect in the brain. The results show that generalized negative affect is encoded in distributed brain regions, while stimulus-type-specific negative affect is encoded in early sensory pathways. Both types of representations are important for predicting subjective experience.
NATURE NEUROSCIENCE
(2022)
Article
Mechanics
Harshal P. Mahamure, Vagesh D. Narasimhamurthy, Lihao Zhao
Summary: This study investigates the dispersion of tiny inertial particles in the two-dimensional laminar wake of a pair of square cylinders placed side-by-side. The effect of varying the cross-stream spacing between the cylinders on the body impaction and dispersion of particles in the wake flow is examined. The results show that the impaction efficiency of different particles is dependent on the spacing ratio and their Stokes number.
INTERNATIONAL JOURNAL OF MULTIPHASE FLOW
(2023)
Article
Medicine, General & Internal
Elizabeth M. Magnan, Daniel J. Tancredi, Guibo Xing, Alicia Agnoli, Anthony Jerant, Joshua J. Fenton
Summary: Opioid tapering is associated with increased emergency department visits and hospitalizations, decreased primary care visits, and reduced medication adherence in patients on long-term opioid therapy. These findings highlight the unintended negative consequences of tapering and should be considered by policy makers and clinicians.
Article
Anesthesiology
Josep Roman-Juan, Elisabet Sanchez-Rodriguez, Ester Sole, Elena Castarlenas, Mark P. Jensen, Jordi Miro
Summary: The purpose of this study was to examine the associations between anxiety, depressive symptoms, and pain catastrophizing with pain medication use in adolescents with chronic pain, and to explore if these associations differed by sex. The results showed that pain catastrophizing was a unique predictor of pain medication use. There was no moderating effect of sex on the associations between psychological factors and pain medication use.
Article
Anesthesiology
Asimina Lazaridou, Marc O. Martel, Marise Cornelius, Olivia Franceschelli, Claudia Campbell, Michael Smith, Jennifer A. Haythornthwaite, John R. Wright, Robert R. Edwards
Article
Anesthesiology
Timothy H. Wideman, Robert R. Edwards, David M. Walton, Marc O. Martel, Anne Hudon, David A. Seminowicz
CLINICAL JOURNAL OF PAIN
(2019)
Article
Anesthesiology
Jeungchan Lee, Ishtiaq Mawla, Jieun Kim, Marco L. Loggia, Ana Ortiz, Changjin Jung, Suk-Tak Chan, Jessica Gerber, Vincent J. Schmithorst, Robert R. Edwards, Ajay D. Wasan, Chantal Berna, Jian Kong, Ted J. Kaptchuk, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Article
Anesthesiology
Samantha M. Meints, Ishtlaq Mawla, Vitaly Napadow, Jian Kong, Jessica Gerber, Suk-Tak Chan, Ajay D. Wasan, Ted J. Kaptchuk, Christina McDonnell, Junie Carriere, Bruce Rosen, Randy L. Gollub, Robert R. Edwards
Article
Anesthesiology
Jieun Kim, Ishtiaq Mawla, Jian Kong, Jeungchan Lee, Jessica Gerber, Ana Ortiz, Hyungjun Kim, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Review
Clinical Neurology
Alex M. Dressler, Andrea G. Gillman, Ajay D. Wasan
JOURNAL OF PAIN RESEARCH
(2019)
Article
Anesthesiology
Binlong Zhang, Minyoung Jung, Yiheng Tu, Randy Gollub, Courtney Lang, Ana Ortiz, Joel Park, Georgia Wilson, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay Wasan, Robert Edwards, Jeungchan Lee, Vitaly Napadow, Ted Kaptchuk, Bruce Rosen, Jian Kong
BRITISH JOURNAL OF ANAESTHESIA
(2019)
Article
Health Care Sciences & Services
Yannick Tousignant-Laflamme, Chad E. Cook, Annie Mathieu, Florian Naye, Frederic Wellens, Timothy Wideman, Marc-Olivier Martel, Olivier Tri-Trinh Lam
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2020)
Review
Clinical Neurology
Alberto Babiloni, Beatrice P. De Koninck, Gabrielle Beetz, Louis De Beaumont, Marc O. Martel, Gilles J. Lavigne
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Neurosciences
Hyungjun Kim, Ishtiaq Mawla, Jeungchan Lee, Jessica Gerber, Kathryn Walker, Jieun Kim, Ana Ortiz, Suk-Tak Chan, Marco L. Loggia, Ajay D. Wasan, Robert R. Edwards, Jian Kong, Ted J. Kaptchuk, Randy L. Gollub, Bruce R. Rosen, Vitaly Napadow
Article
Multidisciplinary Sciences
Benedict J. Alter, Nathan P. Anderson, Andrea G. Gillman, Qing Yin, Jong-Hyeon Jeong, Ajay D. Wasan
Summary: This study utilized an algorithmic approach to group patients by pain distribution, finding that pain distribution subgroups were significantly associated with differences in pain intensity, impact, and clinically relevant outcomes.
Editorial Material
Anesthesiology
Connor Richardson, Harry Burke, Zach Frabitore, Ruth Segall, Malcolm Moses-Hampton, Raj Kubendran, Kevin Woeppel, Ajay D. Wasan, Trent Emerick
Article
Anesthesiology
Ajay D. Wasan, Robert R. Edwards, Kevin L. Kraemer, Jong Jeong, Megan Kenney, Kevin Luong, Marise C. Cornelius, Caitlin Mickles, Bhagya Dharmaraj, Essa Sharif, Anita Stoltenberg, Trent Emerick, Jordan F. Karp, Matt J. Bair, Steven Z. George, William M. Hooten
Summary: The study aims to investigate the prevalence of comorbid depression or anxiety disorders in patients with chronic low back pain (CLBP). The presence of negative affect (NA) in CLBP patients is associated with increased pain, worse treatment outcomes, and higher rates of prescription opioid misuse. The SYNNAPTIC protocol is designed to evaluate the effectiveness of antidepressants, fear-avoidance rehabilitation, or their combination in treating CLBP patients with high NA.
Article
Psychology, Clinical
M. Gabrielle Page, Daniel Ziemianski, Marc Olivier Martel, Yoram Shir
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2019)
Article
Neuroimaging
Wei Shen, Yiheng Tu, Randy L. Gollob, Ana Ortiz, Vitaly Napadow, Siyi Yu, Georgia Wilson, Joel Park, Courtney Lang, Minyoung Jung, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay D. Wasan, Robert R. Edwards, Ted Kaptchuk, Shasha Li, Bruce Rosen, Jian Kong
NEUROIMAGE-CLINICAL
(2019)
