Review
Oncology
Zidi Zhou, Zhilong Yang, Jingzhi Wang, Qiang Wang, Heng Zhang, Xiaoli Ju
Summary: Tumour-associated macrophages (TAMs) play a crucial role in gastric cancer, with their quantity predicting disease progression and metastasis, significantly impacting the treatment and prognosis of patients with gastric cancer.
Article
Oncology
Shuo Wang, Haiyang Jiang, Caiwei Zheng, Ming Gu, Xinyu Zheng
Summary: In this study, the role of tumor-associated macrophages (TAMs) in promoting breast cancer microcalcifications by secreting bone morphogenetic protein 2 (BMP-2) was elucidated. It was found that the presence of microcalcifications was significantly associated with the increased expression of CD168 and BMP-2, as well as poor prognosis. These findings suggest that TAMs contribute to the formation of microcalcifications in breast cancer cells through multiple pathways involving BMP-2 and its downstream factors.
Article
Cell Biology
Makon-Sebastien Njock, Tina O'Grady, Olivier Nivelles, Michelle Lion, Sophie Jacques, Maureen Cambier, Stephanie Herkenne, Florian Muller, Aurelie Christian, Claire Remacle, Julien Guiot, Souad Rahmouni, Franck Dequiedt, Ingrid Struman
Summary: This study found that endothelial cell-derived extracellular vesicles (EVs) participate in the recruitment of macrophages within the tumour in the tumour microenvironment, leading to a change in the immunomodulatory phenotype and promoting tumour growth.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Oncology
Li-Ren Jiang, Ning Zhang, Si-Teng Chen, Jin He, Yong-Hua Liu, Ya-Qin Han, Xiao-Qin Shi, Ji-Ji Yang, Dong-Yun Mu, Guo-Hui Fu, Feng Gao
Summary: PD-1-positive TAMs may serve as a negative survival indicator in MIBC patients, and their mechanistic effects could result from a combination of PD-1 and CD68 activity. High immune score and M2 TAMs are strongly associated with poor clinical outcomes in MIBC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhongwei Li, Pengfei Wang, Wenjie Cui, Hongmei Yong, Diandian Wang, Tiesuo Zhao, Wenwen Wang, Ming Shi, Junnian Zheng, Jin Bai
Summary: The study found that DNMT1 is overexpressed in breast cancer and promotes tumorigenesis and metastasis by activating its expression through ZEB1 and P300, and increasing its expression through the IL-6-pSTAT3-ZEB1-DNMT1 axis in the tumor microenvironment.
CELL AND BIOSCIENCE
(2022)
Review
Cell Biology
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Summary: Tumour-Associated Macrophages (TAMs) are a key component of the tumour microenvironment, with complex roles in cancer immunity. TAMs can exhibit both pro-tumour and anti-cancer activities. Advanced single-cell technology has revealed novel dedifferentiation phenomena of TAMs. Additionally, TAMs show potential in cancer immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Constanze L. Kemmerer, Jens Schittenhelm, Evelyn Dubois, Laura Neumann, Lisa M. Haesler, Marius Lambert, Mirjam Renovanz, Stephan A. Kaeser, Ghazaleh Tabatabai, Ulf Ziemann, Ulrike Naumann, Markus C. Kowarik
Summary: Diffuse gliomas are common malignant brain tumors with poor treatment outcomes. This study found that immune cell infiltration in these tumors is generally low and does not correlate with cytokine concentrations in the cerebrospinal fluid. However, macrophage infiltrates are associated with cytokine changes in the CSF, potentially shaping the tumor microenvironment. Further research is needed to fully understand the role of the immune system in these tumors.
Article
Medical Laboratory Technology
Mohammed Haseeb Chohan, Matthew Perry, Paul Laurance-Young, Vehid M. Salih, Andrew D. Foey
Summary: Oral squamous cell carcinoma (OSCC) is a common malignant cancer in humans. Tumour associated macrophages (TAMs) and PD-L1 play different roles in the prognosis of OSCC patients.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Yu Wang, Muhan Xu, Jian Sun, Xiaoxiao Li, Huazheng Shi, Xuefeng Wang, Benming Liu, Tao Zhang, Xu Jiang, Liangyu Lin, Qing Li, Yin Huang, Yong Liang, Mingyuan Hu, Fanjun Zheng, Fengyu Zhang, Jian Sun, Yufang Shi, Ying Wang
Summary: In this study, the researchers investigate how interactions between neutrophils and T cells in lymphoid tissues away from the tumour area, as well as metabolic competition between these immune cell populations, impair anti-tumour immunity in breast cancer. They found that the spleens of both humans and mice with breast cancer undergo metabolic reprogramming to a glycolytic state, which influences the microenvironment and negatively affects T cell responses. They also discovered that the CCL9 chemokine produced by splenic stromal cells is crucial for neutrophil accumulation, and blocking the CCR1 receptor promotes tumour eradication.
Article
Oncology
Zijian Wang, Zhixiang Du, Haoyu Sheng, Xiuliang Xu, Wenjie Wang, Jian Yang, Jian Sun, Jianghua Yang
Summary: Schistosomal CRC and non-schistosomal CRC patients exhibit different clinicopathological features and prognosis, with schistosomiasis being a risk factor for CRC and M2 TAMs serving as independent prognostic factors for OS.
Article
Peripheral Vascular Disease
Xiao-Jing Chen, Wen-Fei Wei, Zi-Ci Wang, Nisha Wang, Chu-Hong Guo, Chen-Fei Zhou, Luo-Jiao Liang, Sha Wu, Li Liang, Wei Wang
Summary: A novel lymphatic pattern LVEM encapsulating lymphatic vessels by TAMs in the hypoxic TME promotes metastasis of CSCC. IL-10 derived from hypoxic TAMs induces Sp1 upregulation in LECs, facilitating LVEM formation and a positive feedback loop that strengthens LNM. Knockdown of Sp1 or blockage of CCL1 disrupts LVEM formation and attenuates LNM.
Article
Oncology
Mieke C. Zwager, Rico Bense, Stijn Waaijer, Si-Qi Qiu, Hetty Timmer-Bosscha, Elisabeth G. E. de Vries, Carolien P. Schroder, Bert van der Vegt
Summary: The purpose of this study was to optimize the assessment of tumour-associated macrophage subsets in different breast cancer subtypes and relate them to clinicopathological characteristics and clinical outcomes. The results showed that CD68+, CD163+, and CSF-1R+ macrophages correlated with tumour grade in Luminal-B breast cancer. However, total or subset TAM numbers did not correlate with disease outcome in any breast cancer subtype.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Gastroenterology & Hepatology
Yongsheng Li, Zhiyong Shen, Zhen Chai, Yizhi Zhan, Yaowei Zhang, Zhengyu Liu, Yuechen Liu, Zhenkang Li, Mingdao Lin, Zhanqiao Zhang, Wei Liu, Shenyuan Guan, Jinchao Zhang, Junying Qian, Yi Ding, Guoxin Li, Yuan Fang, Haijun Deng
Summary: This study found that the transmembrane protein MS4A4A, selectively expressed in tumor-associated macrophages (TAMs), can suppress the efficacy of immune checkpoint inhibitors. Blockade of MS4A4A can inhibit tumor growth and improve the efficacy of immune checkpoint inhibitors. This research reveals the role of MS4A4A in tumor immune escape and proposes a new anticancer immunotherapy targeting MS4A4A.
Article
Oncology
Shenshan Jia, Yanying Wang, Hongjiang He, Cheng Xiang
Summary: The study demonstrated that superselective neck dissection (SSND) removing lymph nodes in levels IIA and III is safe and effective for patients with supraglottic squamous cell carcinoma (SCC) of the larynx and clinically negative neck. The spinal accessory nerve function was maintained without compromising clinical outcome.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
