Highlighting the versatility of the Tracerlab synthesis modules. Part 2: fully automated production of [11C]-labeled radiopharmaceuticals using a Tracerlab FXC-Pro

The field of radiochemistry is moving toward exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move not only comes with many advantages but also presents radiochemists with the challenge of re-configuring synthesis modules for production of radiopharmaceuticals that require non-conventional radiochemistry while maintaining full automation. Herein, we continue our series of articles showcasing the versatility of the Tracerlab FX synthesis modules by presenting straightforward, fully automated methods for preparing a range of carbon-11 labeled radiopharmaceuticals using a Tracerlab FXC-Pro. Strategies for production of [11C]acetate, [11C]carfentanil, [11C]choline, [11C]3-amino-4-[2-[(di(methyl)amino)methyl]phenyl]sulfanylbenzonitrile ([11C]DASB), (+)-a-[11C]dihydroterabenazine ([11C]DTBZ), [11C]flumazenil ([11C]FMZ), meta-hydroxyephedrine ([11C]HED), [11C]methionine, [11C]PBR28, [11C]Pittsburgh Compound B ([11C]PiB), 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), and [11C]raclopride are presented. Copyright (C) 2011 John Wiley & Sons, Ltd.