Article
Pharmacology & Pharmacy
M. E. Abdel-Hameed, Nourihan S. Farrag, H. Aglan, Abeer M. Amin, M. A. Mahdy
Summary: This study highlights the effective use of silver nanoparticles in improving the tumor targeting efficiency of the chemotherapy agent epirubicin. The nanoparticles were conjugated with epirubicin and radio-iodinated, showing promising results in tumor targeting and imaging. The findings suggest the potential of using these nanoparticles for tumor treatment and imaging.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Rajan Radha Rasmi, V. B. Kadwad, Jayula Sarnaik, K. Bhasker Shenoy, H. M. Somashekarappa
Summary: C-Peptide radioimmunoassay is a valuable tool for diagnosing diabetes, insulinoma, and hypoglycemia. The developed assay using a polyclonal antibody for human C-peptide raised in rabbits has shown superior features such as a standard range of 0.3-18 ng/mL and low non-specific binding for routine clinical sample analysis.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jerome Lozada, Wen Xuan Lin, Rosana M. Cao-Shen, Ruyin Astoria Tai, David M. Perrin
Summary: In this study, a unprecedented salt metathesis between a variety of BF4- salts and a series of organoboronic acids yielding the corresponding organotrifluoroborates was reported. Conditions for fast and efficient fluoridation (<1 h) with minimal workup were identified. Fundamentally, this work discloses the proclivity of BF4- to exchange fluoride atoms with organoboronates, highlighting the lability of BF4-.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Medicinal
Archana Mukherjee
Summary: The field of nuclear medicine is rapidly evolving due to the high demand for radiopharmaceuticals for diagnostic and therapeutic applications. Kit formulations simplify the preparation of radiopharmaceuticals, enabling extensive applications of various isotopes for imaging and therapy.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Christine M. Le
Summary: This article examines the role of 2-[18F]fluoro-2-deoxyglucose and highlights how this radioactive sugar could be instrumental in saving lives.
Article
Biochemistry & Molecular Biology
Krishan Kumar, Karen Woolum
Summary: A novel reagent NH2Cl was developed and successfully used for radioiodine labeling of amino acids, peptides, and proteins with over 70% yield in non-radioactive iodine labeling reactions. The reagent demonstrated selectivity for iodinating the tyrosine residue in biomolecules.
Article
Biotechnology & Applied Microbiology
Xiumin Shi, Qing Li, Chuan Zhang, Hailong Pei, Guanglin Wang, Hui Zhou, Longfei Fan, Kai Yang, Bo Jiang, Feng Wang, Ran Zhu
Summary: A semiconducting polymer nano-radiopharmaceutical labeled with therapeutic radioisotope Lu-177 (Lu-177-SPN-GIP) was developed for combined radio- and photothermal therapy of pancreatic tumor, showing enhanced therapeutic capability compared to individual treatments. Lu-177-SPN-GIP demonstrated strong cell uptake, long retention in tumor site, and the ability to suppress tumor stem cell growth and reverse EMT, potentially reducing metastasis.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chao Li, Ran Ding, Heng-Yi Guo, Shuang Xia, Lei Shu, Pei-Long Wang, Hongji Li
Summary: In this study, we report a rare catalyst-free electrochemical cross-coupling reaction that can forge various types of chemical bonds at room temperature. The study also reveals the dual role of organotrifluoroborates as both coupling partner and electrolyte in the C-H functionalization reaction.
Article
Biochemistry & Molecular Biology
Mona O. Sarhan, Somaia S. Abd El-Karim, Manal M. Anwar, Raghda H. Gouda, Wafaa A. Zaghary, Mohammed A. Khedr
Summary: The newly synthesized 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl compound 2b showed potential anticancer activity against multiple cancer cell lines, with good stability and selective targeting of tumor cells demonstrated in molecular dynamic studies. It can be considered as a promising radiotheranostic agent for solid tumors.
Article
Chemistry, Inorganic & Nuclear
Yujue Wang, Truc T. Huynh, Nilantha Bandara, Hong-Jun Cho, Buck E. Rogers, Liviu M. Mirica
Summary: A new series of bifunctional chelators with high affinity for amyloid beta aggregates and strong binding affinity towards Cu(II) were reported, showing favorable lipophilicity for potential blood-brain barrier penetration. The compounds tested formed stable Cu-64-radiolabeled complexes with favorable partition coefficients, and two of them exhibited significant staining of amyloid plaques in ex vivo autoradiography studies.
DALTON TRANSACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Mai Lin, Ryan P. Coll, Allison S. Cohen, Dimitra K. Georgiou, Henry Charles Manning
Summary: Molecular imaging is a visual method used to study biological processes at the cellular or molecular level in living organisms. PET, among all imaging modalities, has significant advantages in sensitivity and quantification of imaging after corrections. PET, with the ability to label various biological molecules, has been widely used in molecular imaging. This article provides an overview of the recent advances in PET radiopharmaceuticals and their clinical applications in oncology.
Review
Pharmacology & Pharmacy
Giulia Poletto, Laura Evangelista, Francesca Venturini, Fabiana Gramegna, Flavio Seno, Stefano Moro, Roberto Vettor, Nicola Realdon, Diego Cecchin
Summary: This narrative review evaluates the use of nanoparticles (NPs) for delivering radionuclides to targets, focusing on systems tested in pre-clinical and clinical settings. A literature search retrieved data from significant studies, showing that all seven classes of nanoparticles have been extensively tested in clinical trials, but they have drawbacks. Liposomes are the only nanoparticles tested for clinical applications, but they have not been commercialized. Based on the current state, radiolabeled NPs require further investigation before finding their place in nuclear medicine.
Review
Biology
Deepak Kaushik, Pooja Jangra, Ravinder Verma, Deepika Purohit, Parijat Pandey, Sandeep Sharma, Rakesh Kumar Sharma
Summary: The article discusses the importance and development trends of radioisotopes and radiopharmaceuticals in modern healthcare, emphasizing safety and effectiveness issues in regulation, as well as the challenges and uncertainties that exist in the field.
JOURNAL OF BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stanislav A. Petrov, Mekhman S. Yusubov, Elena K. Beloglazkina, Valentine G. Nenajdenko
Summary: This review presents the progress made in the synthesis of radioiodinated compounds over the past decade. It discusses the possibilities and limitations of radiopharmaceuticals with different iodine isotopes, as well as the synthesis of low and high molecular weight compounds containing radioiodine. The review also analyzes synthesis strategies, substrate frameworks, isolation methods, and metabolic stability, and explores the potential for industrial production of radioiodinated organic derivatives for drug synthesis and diagnostics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Jon Ander Simon, Emilia Utomo, Felix Pareja, Maria Collantes, Gemma Quincoces, Aaron Otero, Margarita Ecay, Juan Dominguez-Robles, Eneko Larraneta, Ivan Penuelas
Summary: The use of intranasal implantable drug delivery systems has great potential for sustained drug delivery. This study presents a novel approach using radiolabeled risperidone intranasal implants, which can provide valuable data for the optimization of drug delivery systems. The implants were successfully administered to rats and showed a slow and steady release of the drug over a month. This experimental approach enables high-resolution imaging of drug release, contributing to the development of improved pharmaceuticals.
