Journal
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume 29, Issue 8, Pages 1038-1041Publisher
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2014.29.8.1038
Keywords
Immunity; Innate; Diabetes Mellitus; Autoimmunity; Lipids; Toll-like Receptor; Nod-like Receptor
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Funding
- Global Research Laboratory Grant of National Research Foundation of Korea [K21004000003-10A0500-00310]
- Bio Research & Development Program [2008-04090]
- National Research Foundation of Korea [2010-00347] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.
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