Article
Biochemistry & Molecular Biology
Haiyan Zhou, Tangting Chen, Yongjie Li, Jingcan You, Xin Deng, Ni Chen, Tian Li, Youkun Zheng, Rong Li, Mao Luo, Jianbo Wu, Liqun Wang
Summary: This study found that Tie-2 is modified by AGEs in diabetes, leading to the inhibition of Ang-1 signaling activation and angiogenesis. This finding provides a novel mechanism for Ang-1/Tie-2 signal dysfunction and angiogenesis failure in diabetic ischemic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fang-Yuan Liu, Guo Nan Yin, Jiyeon Ock, Fitri Rahma Fridayana, Lashkari Niloofar, Yan Huang, Minh Nhat Vo, Jun-Kyu Suh, Soon-Sun Hong, Ju-Hee Kang, Ji-Kan Ryu
Summary: Severe vascular and nerve damage from diabetes leads to erectile dysfunction and poor response to oral phosphodiesterase 5 inhibitors. The study showed that administration of Ago2 can effectively improve penile erection in diabetic mice by enhancing cavernous endothelial cell angiogenesis and survival. Ago2 administration reduces reactive oxygen species production and improves signaling pathways, leading to improved cellular functions and erectile function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Gwang Hyeon Choi, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong
Summary: Plasma levels of Ang-2 in HCC patients correlated with liver function, tumor stage, and tumor invasiveness, showing better performance in predicting OS and PFS compared to AFP, Ang-1, or VEGF.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Anna M. W. ten Voorde, Annemijn P. A. Wierenga, Rogier J. Nell, Pieter A. van der Velden, Gregorius P. M. Luyten, Robert M. Verdijk, Martine J. Jager
Summary: In uveal melanoma, ANG-2 is identified as an important prognostic factor, with high expression associated with high-risk tumors and metastasis development, making it a potential therapeutic target.
Article
Pharmacology & Pharmacy
Xiang Zhou, Shangqian Wang, Ruhua Zhou, Tongtong Zhang, Yichun Wang, Qijie Zhang, Rong Cong, Chengjian Ji, Jiaochen Luan, Liangyu Yao, Xuan Zhou, Ninghong Song
Summary: ED is comorbid with hypospadias in rat models induced by DBP, which might be explained by penile fibrosis, testosterone deficiency, and endothelial dysfunction. These effects are likely mediated through the activation of certain pathways and the suppression of others.
Article
Chemistry, Multidisciplinary
Kishore Naidu Killari, Haritha Polimati, D. S. N. B. K. Prasanth, Gagandeep Singh, Siva Prasad Panda, Girija Sastry Vedula, Vinay Bharadwaj Tatipamula
Summary: This study demonstrates that Salazinic acid (Sa) found in certain lichen genera can counteract the detrimental effects of streptozotocin-induced diabetes on the male reproductive system of rats. By modulating hormone levels and antioxidant status, Sa restores reproductive organ weight, sperm characteristics, and testicular histological structure.
Article
Chemistry, Medicinal
Sang Hong Bak, Jae Heon Kim, Seung U. Kim, Dong-Seok Lee, Yun Seob Song, Hong J. Lee
Summary: This study aimed to establish immortalized rat penile cavernous endothelial cells (rEC) and investigate how they could repair erectile dysfunction in rats with cavernous nerve injury (CNI). The findings showed that transfected rECs expressed CD31 and vWF consistently and were able to repair erectile dysfunction caused by CNI. Therefore, this cell line may be valuable for studying the mechanisms and drug screening of erectile dysfunction in rats.
Article
Endocrinology & Metabolism
Yinghao Yin, Yihong Zhou, Jun Zhou, Liangyu Zhao, Hongji Hu, Ming Xiao, Bin Niu, Jingxuan Peng, Yingbo Dai, Yuxin Tang
Summary: This study investigated the effect of CDDP on erectile function and its possible mechanism. The results showed that CDDP treatment could induce erectile dysfunction by affecting the content of endothelial and smooth muscle and causing cellular senescence and cell death. Clinicians should pay more attention to the erectile function of cancer patients who receive CDDP treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Andrology
Li Liu, Xiao Wang, Kang Liu, Jiaqi Kang, Shangren Wang, Yuxuan Song, Kechong Zhou, Lu Yi, Xiaoqiang Liu
Summary: This study investigated the role of iNOS in diabetes mellitus erectile dysfunction (DMED) and confirmed that upregulation of iNOS leads to microvascular dysfunction in patients with ED. Inhibiting iNOS showed beneficial effects in the treatment of ED, suggesting further exploration of its mechanism is warranted.
Article
Chemistry, Multidisciplinary
Mengmeng Zhao, Xiaoxia Wu, Zengda Yu, Yunkai Sun, Zhao Liu, Jinqiao Yuan, Hu Liu, Yiping Jin
Summary: This study investigates the impurities of Avanafil using a newly developed UPLC method and successfully detects and infers the structures of four impurities. The study also develops an efficient method to separate these impurities and validates its specificity, linearity, precision, accuracy, and sensitivity. These findings are crucial for the quality control of the drug.
Article
Biochemistry & Molecular Biology
Ayokunle O. Ademosun, Ganiyu Oboh, Adeniyi A. Adebayo, Tosin A. Olasehinde, Olamide W. Fasakin
Summary: Grapefruit peel extract has the potential to enhance erectile function and protect against erectile dysfunction induced by paroxetine.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Xiang Zhou, Tongtong Zhang, Lebin Song, Yichun Wang, Qijie Zhang, Rong Cong, Chengjian Ji, Jiaochen Luan, Liangyu Yao, Wei Zhang, Ninghong Song, Shangqian Wang
Summary: The study found that prenatal exposure to DBP can lead to erectile dysfunction in male adult rats, potentially by activating the Akt/Bad/Bax/caspase-3 pathway and suppressing the NOS/cGMP pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Chun-Hou Liao, Kau-Han Lee, Shiu-Dong Chung, Kuo-Chiang Chen, Chellappan Praveen Rajneesh, Bo-He Chen, Jai-Hong Cheng, Wang-Ying Lin, Han-Sun Chiang, Yi-No Wu
Summary: This study aimed to explore the potential of platelet-rich plasma (PRP) treatment for erectile dysfunction (ED) induced by diabetes mellitus (DM). The results showed that PRP treatment significantly improved erectile function in ED patients, reduced atrophy of myelinated nerves, and improved post-surgery survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gianmaria Salvio, Alessandro Ciarloni, Melissa Cutini, Giancarlo Balercia
Summary: Erectile Dysfunction (ED) is linked to cardiovascular conditions, with hyperhomocysteinemia playing a central role in causing endothelial damage and affecting male sexual function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shuying Dong, Zhuxin Li, Jian Kong, Shilun Wu, Jun Gao, Wenbing Sun
Summary: This study found that arsenic trioxide (ATO) can block the paracrine signaling of angiopoietin-1 and angiopoietin-2 by inhibiting p-Akt/Hif-1 alpha, thereby suppressing angiogenesis in hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA).
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Urology & Nephrology
Gwang-Won Kim, Yun-Hyeon Kim, Kwangsung Park, Gwang-Woo Jeong
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2019)
Article
Chemistry, Physical
Sang Jin Lee, Mi Eun Kim, Haram Nah, Ji Min Seok, Myung Ho Jeong, Kwangsung Park, Il Keun Kwon, Jun Sik Lee, Su A. Park
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Endocrinology & Metabolism
Kyung-Jin Oh, Ho Song Yu, Jinju Park, Hyun-Suk Lee, Su A. Park, Kwangsung Park
Article
Chemistry, Analytical
Hyeryun Jeong, Myeongsu Seong, Hyun-Suk Lee, Kwangsung Park, Sucbei Moon, Jae Gwan Kim
Editorial Material
Urology & Nephrology
Kwangsung Park
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Editorial Material
Urology & Nephrology
Kwangsung Park
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Taehee Kim, Ho Seok Chung, Hyun-Suk Lee, Saji Uthaman, In-Kyu Park, Kwangsung Park
Summary: This study aimed to develop HA-based, RA-containing nanomicelles and investigate their effects on regeneration of the vaginal epithelium and AQP3 expression in a murine menopause model. After 4 weeks of treatment, the thickness of the vaginal mucosal epithelial layer and AQP3 expression was increased in the HA-C18-RA group compared with the HA-C18 vehicle group.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Jee Hee Yoon, Ho Seok Chung, A. Ram Hong, Hee Kyung Kim, Ho-Cheol Kang, Myung Soo Kim, Eu Chang Hwang, Seung Il Jung, Kwangsung Park, Dongdeuk Kwon
Summary: This study aimed to investigate kidney outcomes after laparoscopic adrenalectomy for primary aldosteronism, finding that postoperative acute kidney injury (AKI) was not directly correlated with chronic kidney disease (CKD) progression. Preoperative albuminuria may be an independent predictor of CKD progression in patients without preoperative CKD.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Urology & Nephrology
Ho Seok Chung, Hyun-Suk Lee, Kwangsung Park
Summary: This study investigated the effects of estrogen on vaginal epithelial progenitor cells in oophorectomized female rat model. The results showed that estrogen replacement therapy helped restore the expression levels of EPCs in the vagina.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Optics
Hyeryun Jeong, Myeongsu Seong, Kwangsung Park, Jae Gwan Kim
CURRENT OPTICS AND PHOTONICS
(2020)
Article
Urology & Nephrology
Ju Yong Oh, Ho Seok Chung, Seong Hyeon Yu, Myung Soo Kim, Ho Song Yu, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Kwangsung Park, Dongdeuk Kwon
INVESTIGATIVE AND CLINICAL UROLOGY
(2020)
Article
Urology & Nephrology
Jae Young Park, Kwangsung Park, Seong Jin Jeong
INVESTIGATIVE AND CLINICAL UROLOGY
(2020)
Meeting Abstract
Urology & Nephrology
S. H. Yu, J. Y. Oh, S. J. Eun, T. H. Kim, D. G. Lim, J. Kim, Y. H. Seo, S. Kim, H. S. Chung, H. S. Yu, E. C. Hwang, S. -O. Kim, K. J. Oh, S. I. Jung, T. W. Kang, D. Kwon, K. Park
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
J. Y. Oh, Y. H. Seo, S. H. Yu, H. S. Chung, H. S. Yu, S. -O. Kim, K. J. Oh, E. C. Hwang, S. I. Jung, T. W. Kang, D. Kwon, K. Park
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
M. S. Kim, J. Y. Oh, S. J. Eun, T. H. Kim, D. G. Lim, J. Kim, Y. H. Seo, S. H. Yu, H. S. Chung, H. S. Yu, E. C. Hwang, S-O. Kim, K. J. Oh, S. I. Jung, T. W. Kang, D. Kwon, K. Park
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
