Article
Endocrinology & Metabolism
Jing Gao, Yuan Wang, Ya-Nan Yang, Xiao-Yuan Wu, Yan Cui, Zhong-He Zou, Zhuang Cui, Yin Liu
Summary: In patients with premature myocardial infarction (PMI), hyperglycemia indicates more severe lesions, metabolic syndrome (MS) as a whole is an independent risk factor for major adverse cardiovascular events (MACE), and BMI >= 28.0 kg/m(2) and hyperglycemia are associated with MACE.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zegui Huang, Xianxuan Wang, Xiong Ding, Zefeng Cai, Weijian Li, Zekai Chen, Wei Fang, Zhiwei Cai, Yulong Lan, Guanzhi Chen, Weiqiang Wu, Zhichao Chen, Shouling Wu, Youren Chen
Summary: There is an association between new-onset metabolic syndrome at different ages and the risk of cardiovascular diseases. The risk is more intense in the group with metabolic syndrome onset at a younger age.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yo Nam Jang, Jun Hyeok Lee, Jin Sil Moon, Dae Ryong Kang, Seong Yong Park, Jerim Cho, Jang-Young Kim, Ji Hye Huh
Summary: A newly developed continuous MS score specifically for the Korean population has been found to be an independent predictor of ischemic stroke and MI in Korean middle-aged adults. The MS score showed superior model fitness and performance in predicting CV events compared to conventional metabolic syndrome diagnostic criteria (ATP-III).
DIABETES & METABOLISM JOURNAL
(2021)
Review
Nutrition & Dietetics
Shengjing Zhang, Huanfen Wang, Saiya Chen, Shengsheng Cai, Shigeng Zhou, Congling Wang, Xiuyuan Ni
Summary: This review assessed the predictive value of prognostic nutritional index (PNI) on mortality and major adverse cardiac events (MACE) in coronary artery disease (CAD) patients. The meta-analysis found that low PNI was associated with higher mortality and incidence of MACE, while higher PNI was associated with lower mortality and incidence of MACE in CAD patients.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Elena Ermolenko, Anna Simanenkova, Lyubov Voropaeva, Nadezhda Lavrenova, Maryna Kotyleva, Sarkis Minasian, Alena Chernikova, Natalya Timkina, Nikita Gladyshev, Alexander Dmitriev, Alexander Suvorov, Michael Galagudza, Tatiana Karonova
Summary: This study aimed to evaluate the effects of metformin on rats with impaired glucose tolerance (IGT) and found that metformin therapy can improve symptoms of metabolic syndrome and restore intestinal microbiota. These results are important for considering the use of A. muciniphila as a probiotic for MS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mitsuaki Sawano, Yuan Lu, Cesar Caraballo, Shiwani Mahajan, Rachel Dreyer, Judith H. Lichtman, Gail D'Onofrio, Erica Spatz, Rohan Khera, Oyere Onuma, Karthik Murugiah, John A. Spertus, Harlan M. Krumholz
Summary: Younger women have poorer health outcomes than men after experiencing acute myocardial infarction (AMI), and it is unknown whether they have a higher risk for cardiovascular and noncardiovascular hospitalizations in the year after discharge. This study aimed to determine sex differences in causes and timing of 1-year outcomes after AMI in people aged 18 to 55 years. Analysis of data showed that young women with AMI had a higher rate of hospitalization in the year after discharge, with a sex disparity in both coronary-related and noncardiac hospitalizations.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cristian Statescu, Larisa Anghel, Bogdan-Sorin Tudurachi, Andreea Leonte, Laura-Catalina Benchea, Radu-Andy Sascau
Summary: Despite lacking an ideal biomarker for risk assessment in patients with AMI, recent studies have shown promising results. Several novel biomarkers related to the pathophysiological processes in AMI patients have been identified, and their inclusion in multi-biomarker strategies may provide additional prognostic value. Additionally, the use of artificial intelligence algorithms for risk stratification and prognostic assessment has the potential to significantly improve outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Hung -Chen Lin, Shing-Hsien Chou, Pei-Chun Fan, Zhidong Zhu, Junjie Pan, Jian Li, Chih-Hsiang Chang, Victor Chien-Chia Wu, Shao-Wei Chen, Pao-Hsien Chu
Summary: This study aimed to investigate the relationship between day-1 urine cadmium excretion and 30-day mortality in patients with acute myocardial infarction (AMI) at two centers. The results showed that day-1 urine cadmium excretion was positively correlated with 30-day mortality and can be used as a simple, objective prognostic scoring system in AMI patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Peripheral Vascular Disease
Tomomi Hasebe, Naoyuki Hasebe
Summary: Despite advancements in cardiovascular medicine, myocardial infarction (MI) remains a major concern for younger patients, with plaque rupture or erosion being the most common cause, often related to obesity and metabolic syndrome. The prevention and treatment of metabolic syndrome-related risk factors are crucial for primary prevention of cardiovascular disease, particularly MI, in younger patients.
HYPERTENSION RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Johannes Reinhold, Charikleia Papadopoulou, Ranu Baral, Vassilios S. Vassiliou
Summary: A systematic review and meta-analysis showed that iron deficiency (ID) may lead to poorer long-term outcomes in patients with acute coronary syndrome (ACS). However, the impact on short-term prognosis remains inconclusive with heterogeneous findings across studies.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Fuad A. Abdu, Abdul-Quddus Mohammed, Lu Liu, Guoqing Yin, Siling Xu, Ayman A. Mohammed, Redhwan M. Mareai, Yawei Xu, Wenliang Che
Summary: This study investigated the impact of metabolic syndrome (MeS) on clinical outcomes in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). The results showed that MeS is relatively common in MINOCA patients and its presence significantly increases the risk of major adverse cardiovascular events (MACE).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Reka Skoda, Attila Nemes, Gyorgy Barczi, Hajnalka Vago, Zoltan Ruzsa, Istvan F. Edes, Attila Olah, Annamaria Kosztin, Elek Dinya, Bela Merkely, David Becker
Summary: This study aimed to assess the impact of diabetes mellitus (DM) on the clinical outcome and survival of patients with myocardial infarction (MI) who underwent percutaneous coronary intervention (PCI). The results showed that diabetic patients had worse short- and long-term survival compared to non-diabetic patients. The presence of DM was found to be more important than the type of MI in affecting survival, while LV and renal functions had a greater impact on survival than DM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Dennis Winston T. Nilsen, Peder Langeland Myhre, Svein Solheim, Sjur Hansen Tveit, Are Annesonn Kalstad, Kristian Laake, Arnljot Tveit, Ingebjorg Seljeflot
Summary: Total bilirubin, as an antioxidant, can reflect the health status of an individual and serve as a prognostic indicator for cardiovascular disease prevention. This study aimed to assess the association between total bilirubin and cardiovascular events following a myocardial infarction. The results showed that higher concentrations of bilirubin were associated with a lower risk of cardiovascular events, even after adjusting for other factors.
Article
Cardiac & Cardiovascular Systems
Uta Ceglarek, Paul Schellong, Maciej Rosolowski, Markus Scholz, Anja Willenberg, Juergen Kratzsch, Uwe Zeymer, Georg Fuernau, Suzanne De Waha-Thiele, Petra Buettner, Alexander Jobs, Anne Freund, Steffen Desch, Hans-Josef Feistritzer, Berend Isermann, Joachim Thiery, Janine Poess, Holger Thiele
Summary: This study developed a biomarker-based risk score for predicting 30-day mortality in patients with cardiogenic shock complicating acute myocardial infarction. The score was extensively validated and calibrated, showing superior prognostic performance compared to other clinical scores, suggesting it may be a useful tool for early decision-making in cardiogenic shock.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Uta Ceglarek, Paul Schellong, Maciej Rosolowski, Markus Scholz, Anja Willenberg, Juergen Kratzsch, Uwe Zeymer, Georg Fuernau, Suzanne de Waha-Thiele, Petra Buettner, Alexander Jobs, Anne Freund, Steffen Desch, Hans-Josef Feistritzer, Berend Isermann, Joachim Thiery, Janine Poess, Holger Thiele
Summary: This study developed a biomarker-based risk score for stratifying 30-day mortality risk in infarct-related CS. It was extensively validated and calibrated in a prospective cohort of contemporary patients with CS after AMI, outperforming other clinical scores and potentially serving as an early decision tool in CS.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Eun-Seok Shin, Eun Jung Jun, Jung-Kyu Han, Min Gyu Kong, Jeehoon Kang, Chengbin Zheng, Scot Garg, Young Jin Choi, Jang-Whan Bae, Kook-Jin Chun, Doo-Il Kim, Seung-Woon Rha, Sung Yun Lee, Jay Young Rhew, Seong-Ill Woo, Han Cheol Lee, Jin-Ok Jeong, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, In-Ho Chae, Hyo-Soo Kim
Summary: This study examined the impact of sex and initial clinical presentation on the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI). Based on pooled individual patient data from 5 Korean-multicenter drug-eluting stent (DES) registries, it was found that there was no sex difference in cardiac death in SAP and UAP/NSTEMI patients, while in STEMI patients, women had higher rates of cardiac death and all-cause mortality. However, after adjusting for confounders, female sex was not an independent predictor of mortality.
CARDIOLOGY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Ji Bak Kim, Byoung Geol Choi, Seung-Woon Rha
Summary: This study investigated the impact of nitrate therapy on the prognosis of patients with myocardial bridge and coexisting coronary artery spasm. The results showed that long-term nitrate administration did not reduce major adverse cardiovascular events but was associated with a higher incidence of recurrent angina requiring follow-up angiography.
Article
Medicine, General & Internal
Joo Myung Lee, Hyun Sung Joh, Ki Hong Choi, David Hong, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Seung-Hyuk Choi, Jin-Ok Jeong, Jong-Young Lee, Young Jin Choi, Jei-Keon Chae, Seung-Ho Hur, Jang-Whan Bae, Ju-Hyeon Oh, Kook-Jin Chun, Hyun-Joong Kim, Byung Ryul Cho, Doosup Shin, Seung Hun Lee, Doyeon Hwang, Hyun-Jong Lee, Ho-Jun Jang, Hyun Kuk Kim, Sang Jin Ha, Eun-Seok Shin, Joon-Hyung Doh, Joo-Yong Hahn, Hyeon-Cheol Gwon
Summary: This study evaluated the mid-term safety and efficacy of Absorb BVS with meticulous device optimization under intravascular imaging guidance. The results showed that BVS had comparable risks of target vessel failure and patient-oriented composite outcome with DES at 2 years. Meticulous device optimization and avoidance of implantation in small vessels improved the outcomes of BVS.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jung-Joon Cha, Ngoc-Luu Nguyen, Cong Tran, Won-Yong Shin, Seul-Gee Lee, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jinyong Ha, Jung-Sun Kim
Summary: This study aimed to evaluate and compare the diagnostic accuracy of machine learning fractional flow reserve (ML-FFR) based on optical coherence tomography (OCT) with wire-based FFR. OCT and FFR data were obtained for 356 individual coronary lesions in 130 patients. The ML-FFR showed good diagnostic performance in predicting FFR irrespective of the coronary territory, highlighting its potential in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Soohyung Park, Seung-Woon Rha, Byoung Geol Choi, Jang Hyun Cho, Sang Ho Park, Jin Bae Lee, Yong Hoon Kim, Sang Min Park, Jae Woong Choi, Ji Young Park, Eun-Seok Shin, Jae Beom Lee, Jon Suh, Jei Keon Chae, Young Jin Choi, Myung Ho Jeong, Kwang Soo Cha, Seung Wook Lee, Ung Kim, Gi Chang Kim, Woong-Gil Choi, Yun-Hyeong Cho, Deok-kyu Cho, Jihun Ahn, Soon-Yong Suh, Se Yeon Choi, Jae Kyeong Byun, Jin Ah Cha, Soo Jin Hyun, Ji Bak Kim, Cheol Ung Choi, Chang Gyu Park
Summary: This study compared the clinical outcomes of immediate and staged complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease. The study found that the incidence of major adverse cardiovascular events was slightly higher in the immediate revascularization group compared to the staged revascularization group at 1-year follow-up. However, there were no significant differences in other clinical outcomes between the two groups. The study suggests that further large randomized clinical trials are needed to determine the optimal timing of complete revascularization for these patients.
AMERICAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jung-Kyu Han, Doyeon Hwang, Seokhun Yang, Sang-Hyeon Park, Jeehoon Kang, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Seung-Ho Hur, Weon Kim, Seok Yeon Kim, Sang-Hyun Park, Seung Hwan Han, Sang-Hyun Kim, Sanghoon Shin, Yong Hoon Kim, Kyungil Park, Namho Lee, Seung Jin Lee, Jin Won Kim, Hyo-Soo Kim
Summary: This study investigated the efficacy of 3- to 6-month dual antiplatelet therapy (DAPT) compared to 12-month DAPT after percutaneous coronary intervention using third-generation drug-eluting stents. The findings demonstrated that the shorter DAPT duration was noninferior to the longer duration in terms of net adverse clinical events. Further research is needed to generalize these results.
Article
Multidisciplinary Sciences
Bom Lee, Teklay Gebrehaweria Baraki, Byung Gyu Kim, Yong-Joon Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: This study evaluated the impact of various stent expansion indices on clinical outcomes and identified optimal stent implantation criteria using optical coherence tomography (OCT). It found that minimal stent area (MSA) was negatively correlated with the risk of adverse events, while overall volumetric stent expansion was associated with greater risk. Categorical criteria, such as MSA<5.0 mm(2), MSA/distal reference lumen area<90%, and stent expansion by linear model>= 65.0%, were independently associated with adverse events.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Kyung Hoon Cho, Min-Ho Shin, Min Chul Kim, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Hyo-Soo Kim, Seung-Ho Hur, Sang Rok Lee, Jin-Yong Hwang, Seok Kyu Oh, Kwang Soo Cha, Myung Ho Jeong
Summary: Data analysis from KAMIR showed that misdiagnosis of STEMI is not rare and is associated with a significant delay in coronary angiography, leading to increased 1-year mortality for patients with culprit lesions in the left anterior descending artery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Oh-Hyun Lee, Ji Woong Roh, Yongcheol Kim, Nak-Hoon Son, Jay Yi Cho, Daesek Jang, Eui Im, Deok-Kyu Cho, Donghoon Choi
Summary: This study aimed to compare the effectiveness of different medication regimens in preventing radial artery spasm (RAS) during coronary catheterization. The results showed that intra-arterial injection of nitroglycerin (NTG) as a single agent was effective and safe in preventing RAS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Byung Gyu Kim, Sung-Jin Hong, Byeong-Keuk Kim, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Dong-Ho Shin, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: This study aimed to evaluate the BMI-dependent effect of ticagrelor monotherapy after 3-month DAPT compared with 12-month DAPT on clinical outcomes in patients with ACS. The results showed consistent effects of ticagrelor monotherapy after 3-month DAPT on major clinical outcomes, regardless of BMI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Seung-Jun Lee, Woong Chol Kang, Jong-Young Lee, Jin-Bae Lee, Tae-Hyun Yang, Junghan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Bum-Kee Hong, Yangsoo Jang, Myeong-Ki Hong, LODESTAR Investigators
Summary: For patients with coronary artery disease and diabetes mellitus, achieving target LDL-C levels is comparable to high-intensity statin therapy in terms of 3-year clinical efficacy and safety outcomes.
Article
Cardiac & Cardiovascular Systems
Byoung Geol Choi, Jung Boone Kim, Seung-Woon Rha, Min Woo Lee, Michael S. Lee, Suhng Wook Kim, Sunghoi Hong
Summary: This study investigates the prevalence and management of hypertension in Korean adults and evaluates its correlation with the risk of cardiovascular disease (CVD) and stroke. The results show that the longer the duration of hypertension, the higher the risks of CVD and stroke. However, achieving optimal blood pressure control reduces the risk of all CVD and stroke by nearly half.
Article
Medicine, General & Internal
Hyung Joon Joo, Yunjin Yum, Yong Hyun Kim, Jung -Woo Son, Sung Hea Kim, Seonghoon Choi, Seongwoo Han, Mi-Seung Shin, Jin-Ok Jeong, Eung Ju Kim
Summary: This study compared gender differences in patients with resistant hypertension and found that male patients are more susceptible to cardiovascular events. More intensive cardiovascular prevention strategies are needed for male patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Yong-Joon Lee, Sang-Hyup Lee, Seng Chan You, Yong-ho Lee, Seung-Jun Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The study evaluated the safety and efficacy of a moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease. The combination therapy showed comparable cardiovascular benefits with lower drug intolerance and low-density lipoprotein cholesterol levels compared to monotherapy, but no significant difference in new-onset diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Seung-Jun Lee, Jung-Joon Cha, Woong Gil Choi, Wang-Soo Lee, Jin-Ok Jeong, Seonghoon Choi, Yoon-Haeng Cho, Woojung Park, Chang-Hwan Yoon, Yong-Joon Lee, Sung-Jin Hong, Chul-Min Ahn, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Soon Jun Hong, Jung-Sun Kim
Summary: The study aimed to evaluate the outcomes of a moderate-intensity statin with ezetimibe combination in patients with very high risk (VHR) and non-VHR of atherosclerotic cardiovascular disease (ASCVD). The results showed no significant difference in the primary end point between combination therapy and high-intensity statin monotherapy in both VHR and non-VHR patients. Additionally, the combination therapy group had significantly lower levels of low-density lipoprotein cholesterol (LDL-C) compared to the high-intensity statin group, and was associated with greater changes in LDL-C levels and a higher proportion of patients with LDL-C levels below 70 mg/dL. The discontinuation or dose reduction of lipid-lowering drugs due to intolerance occurred less frequently in the combination therapy group.
