Article
Public, Environmental & Occupational Health
Eliza Lai-Yi Wong, Annie Wai-Ling Cheung, Zigui Chen, Amy Yuen-Kwan Wong, Apple Chung-Man Yeung, Peter Sen-Yung Yau, Paul Kay-Sheung Chan
Summary: This study investigated HPV infection among Chinese women with cytological abnormalities and found an overall infection rate of 74%, with 2.3% being cutaneous HPV infection. The prevalence of HPV infection peaked in the 35-39 age group and gradually declined, with a second peak occurring at age 65 and above. HPV58, HPV52, HPV53, HPV16, and HPV18 were the most common high-risk genotypes among women with cytological abnormalities.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Hao Li, Afroditi Boulougoura, Yushiro Endo, George C. Tsokos
Summary: T cell abnormalities are closely associated with the development of SLE, including numerical and functional disturbances in CD4+ and CD8+ T cells, which lead to immune dysregulation and tissue infiltration. These abnormalities are mainly due to signaling defects, metabolic alterations, and epigenetic changes. Novel strategies to correct T cell abnormalities show promise for SLE treatment.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Medicine, Research & Experimental
Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren
Summary: This study compared the characteristics of the oral microbiome between patients with systemic lupus erythematosus (SLE) and healthy controls, and developed an SLE classifier based on the oral microbiota. The results showed that SLE patients had increased oral microbial diversity and a different microbial community compared to healthy controls. Specific microbial changes were identified and used to construct a classifier for diagnosing SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Guanglei Zhong, Yuhan Wang, Qingsheng Xie, Rongchun Lin, Tingting Yao
Summary: HPV-16, 31, 33 and 58 infections are significant risk factors for cervical lesions. Combined HPV genotypes test can effectively predict cytological abnormalities.
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Jon Zubiaur, Alba Herrero-Morant, Adrian Margarida de Castro, Raquel Perez-Barquin, Ivan Ferraz-Amaro, Javier Loricera, Santos Castaneda, Ricardo Blanco
Summary: This retrospective observational study examined the association between cumulative hydroxychloroquine (HCQ) dose and electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE). The results showed that higher cumulative HCQ dose was associated with conduction disturbances, but this association disappeared after multivariate adjustment. There was no significant increase in the development of structural abnormalities.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Haofang Zhu, Bin Kong, Min Nie, Cheng Zhao, Rui Liu, Ying Xie, Yuanjin Zhao, Lingyun Sun
Summary: In this study, a peptide dendrimer-based microgel encapsulated with MSCs was developed using a microfluidic approach for the treatment of SLE. The microgels had tunable diameters, porous microstructures, mechanical stiffness, and immune-isolation potential. The results showed that the MSCs encapsulated microgels enhanced cellular bioactivity, immunomodulatory function, and alleviated disease symptoms.
Review
Oncology
Fatema Alzahraa Samy Amin, Zeba Un Naher, P. Shaik Syed Ali
Summary: This review explores the use of molecular and viral biomarkers for early detection and prediction of HPV-induced cervical lesions that may progress to CC. The study found an association between high-risk HPV-induced cervical lesions and overexpression of markers of oxidative DNA damage and other proteins, as well as dysregulation of certain markers and high methylation levels in advanced cervical lesions, indicating a higher risk of progression to CC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Immunology
S. Giambalvo, C. Garaffoni, E. Silvagni, F. Furini, R. Rizzo, M. Govoni, A. Bortoluzzi
Summary: This systematic literature review aimed to explore the factors associated with fertility outcomes in women of childbearing age with systemic lupus erythematosus (SLE). The study found that exposure to cyclophosphamide and its cumulative dose can impair gonadal function in SLE women, leading to amenorrhea and premature ovarian failure (POF). Certain treatments were associated with a lower risk of POF. Hormonal and serological factors did not appear to impact fertility outcomes, but could be used as surrogate markers of fertility.
AUTOIMMUNITY REVIEWS
(2022)
Article
Medicine, General & Internal
Alessio Buonavoglia, Patrizia Leone, Marcella Prete, Antonio Giovanni Solimando, Chiara Guastadisegno, Gianvito Lanave, Michele Camero, Vito Martella, Lorenzo Lo Muzio, Vito Racanelli
Summary: This study reveals a significant association between EBV and both SLE and SLE-related oral lesions, providing a basis for further investigation into the role of EBV in SLE pathogenesis. The detection rate of EBV varies among different populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Virology
Boning Li, Chen Hua, Pu Tian, Yiou Sha, Lu Zhang, Qian Wang, Lu Lu, Shibo Jiang, Long Sui
Summary: Persistent HR-HPV infection is a major risk factor for cervical cancer, but therapeutic approaches are limited. 25HC has inhibitory effects on various viruses and has potential as an intervention against HPV infection. In this study, the anti-HPV efficacy of 25HC was evaluated using different HPV pseudoviruses in cell and mouse models. The mechanisms behind its inhibitory effects were investigated, revealing that 25HC perturbs F-actin rearrangement by reducing small GTPase prenylation, leading to failed infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Xiaotong Chen, Hui Li, Chunling Wu, Yan Zhang
Summary: This study suggests that EBV infection may be related to the occurrence of SLE, while HHV-6 infection may not have a direct association with the development of SLE. However, in SLE patients, EBV and HHV-6 infection may have a coacceleration effect.
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Min Nie, Guopu Chen, Cheng Zhao, Jingjing Gan, Mihribangvl Alip, Yuanjin Zhao, Lingyun Sun
Summary: The study introduces novel adhesive porous particles encapsulating human MSCs for SLE treatment, inspired by the natural microstructure of the sand tower worm nest. These porous microparticles protect MSCs from immune cells, maintain their functions, and facilitate nutrient exchange. The particles have the potential for chronic SLE treatment and other biomedical applications, showing increased cellular half-life and anti-inflammatory effects in vivo.
BIOACTIVE MATERIALS
(2021)
Review
Rheumatology
Ji-Won Kim, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim
Summary: This study reports a case of a 49-year-old female who experienced a flare of adult-onset Still's disease (AOSD) after receiving the first dose of BNT162b2 mRNA COVID-19 vaccination. The patient presented with fever and nausea 4 days after vaccination and was ultimately treated with steroid pulse therapy. The study also discusses possible mechanisms linking vaccination with a flare of AOSD.
CLINICAL RHEUMATOLOGY
(2022)
Article
Oncology
Ji-Won Kim, Eunyoung A. Lee, Hyoun-Ah Kim, Chang-Hee Suh, Ju-Yang Jung
Summary: This study aimed to analyze the clinical features, outcomes, and reasons for discontinuing TNF inhibitor therapy in older patients with ankylosing spondylitis (AS). Data from a nationwide registry were used to compare clinical variables and outcomes. The study found that older patients had a higher incidence of hypertension and diabetes, and lower drug retention rates. However, improvements in disease activity and manifestations were comparable between older and younger patients.
Article
Medicine, General & Internal
Ju-Yang Jung, Hyun-Young Lee, Eunyoung Lee, Hyoun-Ah Kim, Dukyong Yoon, Chang-Hee Suh
Summary: This study identified three clusters of patients with systemic lupus erythematosus (SLE) based on their initial laboratory findings. These clusters had different laboratory characteristics, but did not differ significantly in terms of damage and mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ji-Won Kim, Sunghoon Park, Ju-Yang Jung, Hyoun-Ah Kim, Seong-Ryul Kwon, Sang Tae Choi, Sung-Soo Kim, Sang-Hyeon Kim, Chang-Hee Suh
Summary: This study investigated the prevalence of and factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). The findings suggest that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Ji-Won Kim, Roh Jin, Jae Ho Han, Jeong-Hyun Kang, Ju-Yang Jung, Chang-Hee Suh, Young-Sil An, Hyoun-Ah Kim
Summary: This study evaluated the association between salivary gland scintigraphy and clinical parameters in patients with primary Sjogren's syndrome (pSS). The results suggest that salivary gland scintigraphy may be an acceptable alternative method, especially when a non-invasive test is required.
CLINICAL RHEUMATOLOGY
(2022)
Article
Oncology
Sun-Kyung Lee, Kichul Shin, Ju-Yang Jung, Chang-Hee Suh, Ji-Won Kim, Hyoun-Ah Kim
Summary: This study aimed to evaluate the long-term retention and safety of bDMARDs and tsDMARDs in patients with RA-ILD and identify factors associated with drug withdrawal. The study found that patients with RA-ILD had lower drug retention rates compared to those without ILD, and Janus kinase inhibitors had the highest retention rate in the RA-ILD group. Factors associated with drug withdrawal included current smoking and concomitant corticosteroid use.
Article
Biochemistry & Molecular Biology
Ju-Yang Jung, Ji-Won Kim, Sang-Won Lee, Wook-Young Baek, Hyoun-Ah Kim, Chang-Hee Suh
Summary: This study evaluates the clinical value of Immunoglobulin gamma-3 chain C (IGHG3) by measuring and comparing its levels in different body fluids of patients with systemic lupus erythematosus (SLE). The levels of IGHG3 in saliva, serum, and urine were measured and analyzed in patients with SLE and healthy controls. It was found that IGHG3 levels were increased in the saliva, serum, and urine of patients with SLE, and correlated with certain clinical characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ye-Ji Kim, Jeein Oh, Soohan Jung, Chan Johng Kim, Jinyong Choi, Yoon Kyung Jeon, Hyun Jik Kim, Ji-Won Kim, Chang-Hee Suh, Yoontae Lee, Sin-Hyeog Im, Shane Crotty, Youn Soo Choi
Summary: Communication between CD4 T cells and cognate B cells is crucial for the maturation of GC-TFH cells and the induction of CD4 T cell-dependent humoral immune response. Mef2d regulates the formation of B:T synapse and the production of IL-21, thus controlling the differentiation of CD4 T cells into GC-TFH cells and the antibody production by B cells. The expression of MEF2D gene is inversely correlated with autoimmune parameters in SLE patients.
SCIENCE IMMUNOLOGY
(2023)
Article
Rheumatology
Wook-Young Baek, Sung-Min Lee, Sang-Won Lee, Chang-Hee Suh
Summary: This study aimed to evaluate the effect of rosuvastatin on inflammatory responses in lupus-prone mice. The results showed that rosuvastatin can decrease serum cholesterol levels and reduce the expression of inflammatory cytokines in lymphoid organs and kidneys. However, it did not improve clinical manifestations, autoantibody titres, or renal histopathology.
JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Endocrinology & Metabolism
Chang-Hee Suh
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Ju-Yang Jung, Chang -Hee Suh, Young-Min Ye, Hyoun-Ah Kim
Summary: This study compared the occurrence of adverse events and disease flares after COVID-19 and influenza vaccination in patients with autoimmune rheumatic diseases (ARDs). The results showed that the rates of adverse events and disease flares were significantly higher after COVID-19 vaccination than after influenza vaccination. Previous allergic reactions to other vaccines were the only factor associated with the occurrence of adverse events. There was no difference in the post-vaccine response between mixed and matched vaccines.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Rheumatology
Ju-Yang Jung, Eunyoung Lee, Ji-Won Kim, Chang-Hee Suh, Kichul Shin, Jinhyun Kim, Hyoun-Ah Kim
Summary: Despite treatment with b/tsDMARDs, patients with D2T RA experience higher disease activity and have a higher rate of drug withdrawal due to inefficacy. Effective therapeutic strategies are needed to improve disease control and treatment outcomes for this unique patient population.
ARTHRITIS RESEARCH & THERAPY
(2023)