Review
Chemistry, Medicinal
Elham Ghobadi, Zahra Ghanbarimasir, Saeed Emami
Summary: Helicobacter pylori is a main causal risk factor for gastric diseases, and eradicating its infection is crucial for prevention and treatment. However, increasing resistance and side effects from conventional therapies highlight the need for new, selective therapeutic agents against H. pylori.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Zhiwen Qi, Hao Zhou, Xingying Xue, Changwei Zhang, Hongxia Chen, Hua Yuan, Chengzhang Wang
Summary: In this study, essential oil loading microcapsules (E-UMs) were successfully prepared with high core content, low release rate, good thermal performance, and antibacterial effect. The application of E-UMs in epoxy coatings can effectively inhibit the proliferation of drug-resistant bacteria.
PROGRESS IN ORGANIC COATINGS
(2021)
Review
Microbiology
Nicole A. Vita, Shelby M. Anderson, Michael LaFleur, Richard E. Lee
Summary: Helicobacter pylori is a significant human pathogen that is becoming increasingly resistant to commonly used antibiotics. Current treatment methods using broad-spectrum antibiotics and proton-pump inhibitors can disrupt the gut microbiome and promote antibiotic resistance. This review explores recent discoveries in new therapies targeting H. pylori, including narrow-spectrum antibiotics and unique mechanisms of action. The development of compounds targeting urease, respiratory complex I, and menaquinone biosynthesis are discussed, as well as strategies to suppress the development of resistance. There is a promising potential to develop novel therapeutics for effectively treating H. pylori infections, as our understanding of its unique physiology expands and advancements in antibacterial drug discovery continue.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Jin-Han Yu, Ying Zhao, Xiao-Feng Wang, Ying-Chun Xu
Summary: Serological testing for H. pylori is widely available and inexpensive, but its performance varies in different populations. This study found significant differences between immunoassay and C-13-UBT results, indicating a need for further evaluation. The serological typing test showed potential for detecting missed infections in high-risk populations.
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Jingfei Hu, Xueqing Tian, Tong Wei, Hangjie Wu, Jing Lu, Mingsheng Lyu, Shujun Wang
Summary: The exopolysaccharide (EPS) extracted from Lactobacillus plajomi PW-7 showed antibacterial activity and antioxidant capacity against Helicobacter pylori. It has a potential application in developing EPS-based foods. The structural characteristics and biological activity of EPS play a key role in its potential applications.
Review
Pharmacology & Pharmacy
Renaly Ivyna de Araujo Rego, Geovana Ferreira Guedes Silvestre, Demis Ferreira de Melo, Sonaly Lima Albino, Marcela Monteiro Pimentel, Sara Brito Silva Costa Cruz, Sabrina Daniela Silva Wurzba, Wellington Francisco Rodrigues, Bolivar Ponciano Goulart de Lima Damasceno, Lucio Roberto Cancado Castellano
Summary: This article provides an overview of the biological and pharmacological activities of flavonoid-rich extracts, focusing on their use against Helicobacter pylori infection to prevent gastric cancer. The study finds that these extracts have potential anti-H. pylori activity, highlighting the importance of researching natural products.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Guerra-Valle, Patricio Orellana-Palma, Guillermo Petzold
Summary: This review discusses the potential impact of plant-based polyphenols on H. pylori and their role in improving gut microbiota.
Article
Biochemistry & Molecular Biology
Ana Thereza Fiori-Duarte, Joao Paulo de Oliveira Guarnieri, Jessica Rodrigues Pereira de Oliveira Borlot, Marcelo Lancellotti, Ricardo Pereira Rodrigues, Rodrigo Rezende Kitagawa, Daniel Fabio Kawano
Summary: The present study describes the search for new inhibitors of H. pylori arginase (HPA) using virtual screening techniques and in vitro evaluations. The results highlighted compounds 6, 11, and 13 as potential inhibitors with improved activity towards H. pylori killing. Compound 13 also exhibited selectivity for gastric adenocarcinoma cells compared to the commercial drug cisplatin. Overall, this study demonstrates the effectiveness of in silico and in vitro approaches in the rational design of new anti-H. pylori drugs.
MOLECULAR DIVERSITY
(2022)
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Microbiology
Tran Thi Dieu Thuy, Pei-Yun Kuo, Sha-Ma Lin, Cheng-Yen Kao
Summary: This study evaluated and compared the anti-Helicobacter pylori activity of three potential probiotic strains and found that SLC13 showed the highest adhesion ability and inhibitory activity. It also alleviated the inflammatory response induced by H. pylori infection.
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetics plays a role in regulating gene expression, cell differentiation, and response to environmental stimuli. Helicobacter pylori (Hp) uses DNA methylation to silence genes in human gastric mucosa, which is a primary cause of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xi Chen, Tiantian Shan, Biao Ren, Lin Zhang, Hockin H. K. Xu, Nanxi Wang, Xuedong Zhou, Hong Li, Lei Cheng
Summary: This study investigated the antibacterial effects of dimethylaminododecyl methacrylate (DMADDM) against H. pylori. The results showed that DMADDM possessed excellent antibacterial and antibiofilm effects on H. pylori, inhibiting its growth and colonization effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Hatun A. Alomar, Noha Fathallah, Marwa M. Abdel-Aziz, Taghreed A. Ibrahim, Wafaa M. Elkady
Summary: This study demonstrates that the essential oil from Cuminum cyminum has the strongest anti-H. pylori activity and good potential for inhibiting H. pylori. It also shows anti-inflammatory activity. The investigated phytochemicals in this study can be used as adjunct therapies with conventional antibiotics for the treatment of H. pylori.
Article
Medicine, General & Internal
Peter Malfertheiner, M. Constanza Camargo, Emad El-Omar, Jyh-Ming Liou, Richard Peek, Christian Schulz, Stella I. Smith, Sebastian Suerbaum
Summary: Helicobacter pylori infection causes chronic gastritis and can lead to severe gastroduodenal pathologies, including peptic ulcer and gastric cancer. This Primer summarizes the epidemiology, pathophysiology, diagnosis and management of this infection, and discusses patient quality of life and open research questions.
NATURE REVIEWS DISEASE PRIMERS
(2023)