Article
Cardiac & Cardiovascular Systems
Mengxing Cai, Shengjie Wu, Songjie Wang, Rujie Zheng, Limeng Jiang, Liyou Lian, Yanlei He, Ling Zhu, Lei Xu, Kenneth A. Ellenbogen, Zachary Whinnett, Lan Su, Weijian Huang
Summary: This study found that LBBP is feasible, safe, and effective in pacemaker-dependent patients with atrial fibrillation and HF after AVJ ablation, and it has similar clinical benefits, a higher implant success rate, better pacing parameters, and fewer complications compared with HBP.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael Vinther, Niels Risum, Jesper Hastrup Svendsen, Rasmus Mogelvang, Berit Thornvig Philbert
Summary: This study compared His-CRT and BiV-CRT in patients with symptomatic heart failure and LBBB, finding similar clinical and physical improvements in both groups at the 6-month follow-up, with His-CRT requiring higher pacing thresholds.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zachary I. Whinnett, Matthew J. Shun-Shin, Mark Tanner, Paul Foley, Badri Chandrasekaran, Philip Moore, Shaumik Adhya, Norman Qureshi, Amal Muthumala, Rebecca Lane, Aldo Rinaldi, Sharad Agarwal, Francisco Leyva, Jonathan Behar, Sukh Bassi, Andre Ng, Paul Scott, Rachana Prasad, Jon Swinburn, Joseph Tomson, Amarjit Sethi, Jaymin Shah, Phang Boon Lim, Andreas Kyriacou, Dewi Thomas, Jenny Chuen, Ravi Kamdar, Prapa Kanagaratnam, Myril Mariveles, Leah Burden, Katherine March, James P. Howard, Ahran Arnold, Pugazhendhi Vijayaraman, Berthold Stegemann, Nicholas Johnson, Emanuela Falaschetti, Darrel P. Francis, John G. F. Cleland, Daniel Keene
Summary: The study evaluated the effects of optimized His bundle pacing compared to no-pacing in patients with heart failure. It was found that His bundle pacing significantly improved quality of life and was preferred by the majority of patients. However, it did not show any significant changes in peak oxygen uptake or left ventricular ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Review
Medicine, General & Internal
Yongzheng Zhang, Mingwang Ding, Zhihong Pu, Wenjia Peng
Summary: This study aims to evaluate the effect of His bundle pacing therapy for chronic heart failure through meta-analysis, analyzing outcomes such as QRS duration, left ventricular function, and heart failure severity.
Review
Cardiac & Cardiovascular Systems
Wen Zhuo, Xiaojie Zhong, Hualong Liu, Jianhua Yu, Qi Chen, Jinzhu Hu, Qinmei Xiong, Kui Hong
Summary: Comparing the pacing parameters and clinical outcomes between His bundle pacing (HBP) and left bundle branch pacing (LBBP), it was found that LBBP had higher implant success rates, lower capture thresholds, larger sensed R wave amplitudes, and greater reduction in QRS duration compared to HBP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chengming Ma, Zhongzhen Wang, Zhulin Ma, Peipei Ma, Shiyu Dai, Nan Wang, Yiheng Yang, Guocao Li, Lianjun Gao, Yunlong Xia, Xianjie Xiao, Yingxue Dong
Summary: The objective of this study was to evaluate the feasibility and outcomes of conduction system pacing (CSP) in heart failure patients. The results showed that CSP was associated with good clinical and echocardiographic responses, improving left ventricular ejection fraction and QRS duration. Additionally, CSP was found to be feasible and safe, even in patients without complete left bundle branch block.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Pugazhendhi Vijayaraman, Clement Rajakumar, Angela M. Naperkowski, Faiz A. Subzposh
Summary: The clinical outcomes of Left Bundle Branch Area Pacing (LBBAP) were comparable to His Bundle Pacing (HBP) among patients undergoing permanent pacemaker implantation.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shengjie Wu, Lan Su, Pugazhendhi Vijayaraman, Rujie Zheng, Mengxing Cai, Lei Xu, Ruiyu Shi, Zhouqing Huang, Zachary Whinnett, Weijian Huang
Summary: Left bundle branch pacing (LBBP) appears to be a promising method for delivering cardiac resynchronization therapy (CRT), showing similar improvements in symptoms and left ventricular function compared with His bundle pacing (HBP) but more significant than biventricular pacing (BVP).
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Annie M. Hirahara, Matthias Lange, Ankur Shah, Muhammad S. Khan, Ravi Ranjan, Greg Stoddard, Derek J. Dosdall
Summary: The study found that selective and nonselective His bundle pacing are more similar to sinus rhythm compared to RV and biV-CRT pacing, with small differences between selective and nonselective pacing not translating into significant differences in the global activation pattern.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Lin Guan, Chuanhe Wang, Xueqing Guan, Gong Cheng, Zhijun Sun
Summary: This meta-analysis evaluated the safety and efficacy of His-Purkinje system pacing (HPCSP) in individuals with atrial fibrillation (AF) complicated by heart failure (HF). The results showed that HPCSP improved cardiac function, reduced mortality and rehospitalization events, and had great clinical application value.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Rehan Mahmud, Eduardo Back Sternick, Damian Sanchez-Quintana, Yolanda Macias, Shakeel Muhammad Jamal, Beth Bailey, Ayush Mohan, Matthew T. Lee, Jenna E. Lee, Marcos Celio de Almeida, Robert H. Anderson
Summary: This study found that histologically specialised pathways connecting the branching component of the atrioventricular conduction axis with the crest of the muscular ventricular septum exist in about three-fourths of the histological datasets. By observing 34 patients undergoing His bundle pacing, it was found that the QRS complex closely resembled known conduction through fasciculo-ventricular pathways in 32 patients, with only two patients not showing a delta wave at any pacing voltages. Therefore, the conclusion was drawn that His bundle pacing can reveal fasciculo-ventricular pathways concealed during sinus rhythm.
Article
Cardiac & Cardiovascular Systems
Ning Wang, Tianyu Zhu, Yan Li, Guanliang Cheng, Yu Chen, Yuwei Fu, Xuezhi Chen, Xiaohui Liu
Summary: This study aimed to investigate the effect of HPSP on tricuspid regurgitation in patients with persistent atrial fibrillation after left-sided valve surgery. The results showed that after 3 months of HPSP implantation, the tricuspid regurgitation grade, velocity, and pressure gradient were significantly reduced, and the patients' cardiac function improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Pugazhendhi Vijayaraman, Parikshit S. Sharma, Oscar Cano, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Francesco Zanon, Marek Jastrzebski, Jiangang Zou, Mihail G. Chelu, Kevin Vernooy, Zachary I. Whinnett, Girish M. Nair, Manuel Molina-Lerma, Karol Curila, Dipen Zalavadia, Abdul Haseeb, Cicely Dye, Sharath C. Vipparthy, Ryan Brunetti, Pawel Moskal, Alexandra Ross, Antonius van Stipdonk, Jerin George, Yusuf K. Qadeer, Mishal Mumtaz, Jeffrey Kolominsky, Syeda A. Zahra, Mehrdad Golian, Lina Marcantoni, Faiz A. Subzposh, Kenneth A. Ellenbogen
Summary: This study compared the clinical outcomes between left bundle branch area pacing (LBBAP) and biventricular pacing (BVP) in patients with cardiac resynchronization therapy (CRT). The results showed that LBBAP improved clinical outcomes compared to BVP and may be a reasonable alternative.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
J. F. Zhang, Y. W. Pan, J. Li, X. G. Kong, M. Wang, Z. M. Xue, J. Gao, G. S. Fu
Summary: This study aims to evaluate a new treatment strategy for patients with persistent atrial fibrillation who have experienced recurrent episodes even after multiple attempts of radio-frequency catheter ablation. The proposed treatment involves atrioventricular node ablation and His-Purkinje conduction system pacing (HPCSP) to control ventricular rate and maintain regular heart rhythm.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Yao Wang, Haojie Zhu, Xiaofeng Hou, Zhao Wang, Fengwei Zou, Zhiyong Qian, Yongyue Wei, Xiang Wang, Longyao Zhang, Xiaofei Li, Zhimin Liu, Siyuan Xue, Chaotong Qin, Jiaxin Zeng, Hui Li, Hongping Wu, Hong Ma, Kenneth A. Ellenbogen, Michael R. Gold, Xiaohan Fan, Jiangang Zou
Summary: Left bundle branch pacing (LBBP) shows greater improvement in left ventricular ejection fraction (LVEF) compared to biventricular pacing (BiVP) in heart failure patients with nonischemic cardiomyopathy and left bundle branch block (LBBB).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Pugazhendhi Vijayaraman
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pugazhendhi Vijayaraman, Grace Hughes, Marilee Manganiello, Alicia Johns, Subham Ghosh
Summary: This study evaluates the non-invasive assessment of ventricular electrical heterogeneity (VEH) using an ECG belt to optimize left bundle branch area pacing (LBBAP).
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zachary I. Whinnett, Matthew J. Shun-Shin, Mark Tanner, Paul Foley, Badri Chandrasekaran, Philip Moore, Shaumik Adhya, Norman Qureshi, Amal Muthumala, Rebecca Lane, Aldo Rinaldi, Sharad Agarwal, Francisco Leyva, Jonathan Behar, Sukh Bassi, Andre Ng, Paul Scott, Rachana Prasad, Jon Swinburn, Joseph Tomson, Amarjit Sethi, Jaymin Shah, Phang Boon Lim, Andreas Kyriacou, Dewi Thomas, Jenny Chuen, Ravi Kamdar, Prapa Kanagaratnam, Myril Mariveles, Leah Burden, Katherine March, James P. Howard, Ahran Arnold, Pugazhendhi Vijayaraman, Berthold Stegemann, Nicholas Johnson, Emanuela Falaschetti, Darrel P. Francis, John G. F. Cleland, Daniel Keene
Summary: The study evaluated the effects of optimized His bundle pacing compared to no-pacing in patients with heart failure. It was found that His bundle pacing significantly improved quality of life and was preferred by the majority of patients. However, it did not show any significant changes in peak oxygen uptake or left ventricular ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Marek Jastrzebski, Grzegorz Kielbasa, Pawel Moskal, Agnieszka Bednarek, Marek Rajzer, Karol Curila, Haran Burri, Pugazhendhi Vijayaraman
Summary: This study compared two methods of right-sided conduction system pacing, right bundle branch pacing (RBBP) and His bundle pacing (HBP). The results showed that RBBP has distinct features separate from HBP, and approximately one-fifth of patients are suitable for RBBP.
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Mariappan Murugan, Vithiya Ganesan, Pugazhendhi Vijayaraman
Summary: This study aimed to analyze the predictors of procedural failure in patients with scarred-left ventricle (LV) undergoing left bundle branch pacing (LBBP). The results showed that successful penetration of the septum during LBBP can improve QRS duration and LV ejection fraction. CMR imaging can predict procedural failure by detecting transmural scar in the LBBP-Zone with high sensitivity and specificity.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Syeda Atiqa Batul, Pugazhendhi Vijayaraman
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Karol Curila, Pugazhendhi Vijayaraman
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Thabish Syed, Pugazhendhi Vijayaraman
Summary: The right ventricle apex remains the standard pacing site in ventricle due to its ease of implantation and procedural safety. However, abnormal ventricular activation and contraction during RV pacing can lead to adverse left ventricular remodelling, predisposing patients to heart failure, atrial arrhythmias, and increased mortality. Pacing induced cardiomyopathy (PIC) is defined by a decline in left ventricular ejection fraction (LVEF), new-onset heart failure symptoms or atrial fibrillation (AF) after pacemaker implantation. The prevalence of PIC varies between 6% and 25%, with certain risk factors associated with increased risk for PIC, such as male sex, chronic kidney disease, previous myocardial infarction, and baseline LVEF.
Letter
Cardiac & Cardiovascular Systems
Ankit Mahajan, Christian Girman, Faiz Ali Subzposh, Pugazhendhi Vijayaraman
Review
Cardiac & Cardiovascular Systems
Jitae A. Kim, Seulgi E. Kim, Kenneth A. Ellenbogen, Pugazhendhi Vijayaraman, Mihail G. Chelu
Summary: Through analyzing the existing data, it was found that conduction system pacing (CSP) has significant advantages over conventional biventricular pacing (BiVP) in terms of clinical outcomes, including reducing all-cause mortality and heart failure hospitalization. However, further large-scale randomized trials are needed to verify these observations.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Vidhya Ganesan, Vijesh Anand, Ramalingam Vadivelu, Mahesh Kumar, Selvaganesh Mariappan, Senthil Murugan, Pugazhendhi Vijayaraman
Summary: This study aimed to assess the behavior of the lumenless lead and the physiological property of the interventricular septum during left bundle branch pacing (LBBP). Three different types of responses were observed during LBBP, with type II response being associated with a soft/cheesy septum, which predisposed the lead to future dislodgments in patients without structural heart disease.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pugazhendhi Vijayaraman, Parikshit S. Sharma, Oscar Cano, Shunmuga Sundaram Ponnusamy, Bengt Herweg, Francesco Zanon, Marek Jastrzebski, Jiangang Zou, Mihail G. Chelu, Kevin Vernooy, Zachary I. Whinnett, Girish M. Nair, Manuel Molina-Lerma, Karol Curila, Dipen Zalavadia, Abdul Haseeb, Cicely Dye, Sharath C. Vipparthy, Ryan Brunetti, Pawel Moskal, Alexandra Ross, Antonius van Stipdonk, Jerin George, Yusuf K. Qadeer, Mishal Mumtaz, Jeffrey Kolominsky, Syeda A. Zahra, Mehrdad Golian, Lina Marcantoni, Faiz A. Subzposh, Kenneth A. Ellenbogen
Summary: This study compared the clinical outcomes between left bundle branch area pacing (LBBAP) and biventricular pacing (BVP) in patients with cardiac resynchronization therapy (CRT). The results showed that LBBAP improved clinical outcomes compared to BVP and may be a reasonable alternative.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Vithiya Ganesan, Pugazhendhi Vijayaraman
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Pugazhendhi Vijayaraman
Article
Cardiac & Cardiovascular Systems
Shunmuga Sundaram Ponnusamy, Vithiya Ganesan, Vadivelu Ramalingam, Mahesh Kumar, Lydia Joyce Rupert, Pugazhendhi Vijayaraman
Summary: This study aimed to analyze the feasibility, efficacy, and long-term outcome of left bundle branch pacing (LBBP) using a lumen-less lead through the right subclavian vein.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)