Article
Engineering, Biomedical
Nan Zhang, Yiqian Huang, Pengfei Wei, Liya Sun, Wei Jing, Yunxia Xue, Yan Zhang, Bo Zhao, Ziang Yang
Summary: Hernia and life-threatening intestinal obstruction often occur due to abdominal wall injuries, which are difficult to regenerate due to the lack of suitable materials. In this study, a multi-therapeutic copper element was introduced to porcine small intestinal submucosa bio-patches, resulting in excellent antibacterial efficiency, cell compatibility, neovascularization, and collagen maturity. This bio-patch shows promise for preventing visceral adhesion, bacterial infection, and promoting soft tissue regeneration.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Akihiro Nishiguchi, Shima Ito, Kazuhiro Nagasaka, Tetsushi Taguchi
Summary: Biodegradable, decellularized extracellular matrix (dECM)-based biological patches reinforced by a supramolecular gelator were developed to treat abdominal wall defects. The reinforced dECM patches had improved mechanical strength and tissue adhesion compared to the original dECM. In vivo experiments demonstrated that the reinforced dECM patches promoted collagen deposition and blood vessel formation, while suppressing the accumulation of CD68-positive macrophages.
Article
Biotechnology & Applied Microbiology
Fengming Luan, Wangbei Cao, Chunhui Cao, Baizhou Li, Xiaoyu Shi, Changyou Gao
Summary: In this study, a new composite biological mesh named SFP was prepared and its mechanism and clinical application value were explored. The results showed that the SFP mesh exhibited good biocompatibility and biofunction in vitro and in vivo, promoting the growth of peritoneal mesenchymal cells and reducing the extent and scope of adhesion between the mesh and abdominal organs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Ying Mao, Yunxiao Meng, Shaojie Li, Yan Li, Robert Guidoin, Yansha Qiao, Ze Zhang, Gaetan Brochu, Jianxiong Tang, Lu Wang
Summary: The study demonstrates that incorporating electrospun nanofibrous membranes as a physical barrier with polypropylene mesh can enhance anti-adhesion capability and promote cell proliferation, with excellent biocompatibility. The density of PP mesh significantly affects cell proliferation, and the composite mesh with NFM barrier shows superior performance in anti-adhesion and tissue compatibility.
MATERIALS & DESIGN
(2021)
Article
Surgery
Michael Katzen, Sullivan A. Ayuso, Jana Sacco, Dau Ku, Gregory T. Scarola, Kent W. Kercher, Paul D. Colavita, Vedra A. Augenstein, B. Todd Heniford
Summary: The use of biologic and synthetic mesh in abdominal wall reconstruction surgery in patients with CDC class 3 and 4 wounds has different advantages and risks. Patients with biologic mesh have a higher risk of hernia recurrence and comorbidities, while patients with synthetic mesh have a higher mesh infection rate and infection-related resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Sullivan A. Ayuso, Bola G. Aladegbami, Kent W. Kercher, Paul D. Colavita, Vedra A. Augenstein, B. Todd Heniford
Summary: This study aimed to determine if there is a difference in wound and mesh infection rates between coated and uncoated polypropylene mesh in patients undergoing open ventral hernia repair. The results showed that the coated group had significantly higher postoperative wound infection rates, the need for intravenous antibiotics, and mesh infection rates compared to the uncoated group.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Sullivan A. Ayuso, Sharbel A. Elhage, Yizi Zhang, Bola G. Aladegbami, Keith S. Gersin, John P. Fischer, Vedra A. Augenstein, Paul D. Colavita, Todd Heniford
Summary: This study aimed to develop and compare deep learning models for predicting rare but devastating postoperative complications after abdominal wall reconstruction. The results showed that deep learning models using a generative adversarial network anomaly framework performed better than conventional deep learning models on imbalanced data sets, primarily by increasing model sensitivity. Understanding patients at risk for rare but severe postoperative complications can improve risk stratification, resource utilization, and the consent process.
Article
Engineering, Biomedical
C. Garcia-Garcia, M. T. Carrascal-Morillo, J. T. Castell Gomez, C. Bernal Guerrero, J. C. Garcia Prada
Summary: This study aimed to compare the mechanical behavior of the Spider prototype mesh with four commercial meshes at the mesh-tissue interface. The results revealed significant anisotropy in commercial meshes and isotropy in the Spider prototype. Nearly isotropic mesh ensures better performance in repairing large-sized ventral hernia defects.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Surgery
Elizabeth Bashian, Georges Daoud, Ibrahim Khansa, Jeffrey E. Janis
Summary: In this study, self-adhering mesh was found to have similar long-term outcomes to transfascially sutured mesh in ventral hernia repair. It resulted in shorter surgery time, shorter length of hospital stay, and a tendency toward improved pain control.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
C. G. Delong, K. T. Crowell, A. T. Liu, M. J. Deutsch, J. S. Scow, E. M. Pauli, C. M. Horne
Summary: This article describes the experience of using one- and two-stage approaches for complex gastrointestinal reconstruction and abdominal wall reconstruction, with a focus on patients who did not complete all planned stages. The study found that although patients in the two-stage group had more risk factors for complications, there were no significant differences in outcomes between patients who completed the two-stage approach and those who completed the one-stage approach.
Article
Surgery
Claudio Birolini, Eduardo Yassushi Tanaka, Jocielle Santos de Miranda, Abel Hiroshi Murakami, Sergio Henrique Bastos Damous, Edivaldo Massazo Utiyama
Summary: The use of PVDF mesh in the treatment of infected abdominal wall defects showed favorable short-term outcomes with a low incidence of wound infection.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Surgery
Yurie Sekigami, Tina Tian, Sydney Char, Jacob Radparvar, Jeffrey Aalberg, Lilian Chen, Abhishek Chatterjee
Summary: This study aims to examine the accuracy of reporting conflicts of interest (COI) in studies related to mesh use in ventral hernia repair and abdominal wall reconstruction. The results show that the majority of studies did not accurately declare COI, and last authors are at the highest risk of undisclosed payments. Current policies on disclosing COI appear to be insufficient to ensure transparency in publications.
Article
Surgery
Arturo J. Rios-Diaz, Jessica R. Cunning, Ankoor A. Talwar, Adrienne Christopher, Robyn B. Broach, Jesse Y. Hsu, Jon B. Morris, John P. Fischer
Summary: Repairing incisional hernias is associated with postoperative complications and healthcare utilization after abdominal operations.
Article
Biochemistry & Molecular Biology
Sophia M. Schmitz, Marius J. Helmedag, Andreas Kroh, Daniel Heise, Uwe Klinge, Andreas Lambertz, Mathias W. Hornef, Ulf P. Neumann, Roman M. Eickhoff
Summary: This study aims to evaluate the influence of a modified mesh structure on bacterial infection. The results indicate that the mesh material is more important for the risk of infection than the variation in filament linking.
Article
Surgery
C. L. Devin, M. A. Olson, L. Tastaldi, R. Zheng, A. C. Berger, F. Palazzo
Summary: In the presence of infection, there were no higher rates of short-term complications between complete repair and partial repair during infected mesh removal and concurrent incisional hernia repair, according to data from a multicenter hernia registry analysis.