Article
Medicine, General & Internal
Jon Zubiaur, Alba Herrero-Morant, Adrian Margarida de Castro, Raquel Perez-Barquin, Ivan Ferraz-Amaro, Javier Loricera, Santos Castaneda, Ricardo Blanco
Summary: This retrospective observational study examined the association between cumulative hydroxychloroquine (HCQ) dose and electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE). The results showed that higher cumulative HCQ dose was associated with conduction disturbances, but this association disappeared after multivariate adjustment. There was no significant increase in the development of structural abnormalities.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Julia Mercader-Salvans, Maria Garcia-Gonzalez, Juan C. Quevedo-Abeledo, Adrian Quevedo-Rodriguez, Alejandro Romo-Cordero, Soledad Ojeda-Bruno, Fuensanta Gomez-Bernal, Raquel Lopez-Mejias, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: Ratios derived from complete blood count can be used as inflammatory biomarkers in systemic lupus erythematosus (SLE) patients. Despite lower cell counts, NLR, MLR, and PLR are higher in SLE patients. However, the relationship between these scores and disease characteristics is limited, with the complement system being the most consistent.
Article
Rheumatology
Alicia Garcia-Dorta, Juan Carlos Quevedo-Abeledo, Inigo Rua-Figueroa, Antonia M. de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Lilian Medina-Vega, Agustin F. Gonzalez-Rivero, Felix Francisco-Hernandez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: The study found that markers of beta-cell secretion were higher in SLE patients compared to controls, especially in patients undergoing glucocorticoid therapy. This disproportionate hyperproinsulinemia may be associated with damage caused by the disease.
Review
Immunology
Aifen Li, Fengbiao Guo, Quanren Pan, Shuxian Chen, Jiaxuan Chen, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unclear pathogenesis and lack of effective treatments. Mesenchymal stem cell (MSC) therapy has shown promise in treating refractory SLE by modulating immune cells, but its effectiveness and safety in SLE patients require further validation through experimental and clinical evidence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Huixian Chen, Fan Wang, Ye Yang, Bingzhu Hua, Hong Wang, Jie Chen, Xuebing Feng
Summary: Research shows that hearing loss is not uncommon in patients with systemic lupus erythematosus, and extended high frequency audiometry can help identify early hearing impairment. A high Systemic Lupus International Collaborating Clinics Damage Index and secondary Sjogren's syndrome may predict the presence of hearing loss in SLE patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Haoyang Chen, Hengmei Cui, Yaqin Geng, Tiantian Jin, Songsong Shi, Yunyun Li, Xin Chen, Biyu Shen
Summary: This study aimed to establish a prediction model to assess the occurrence of depression in patients with SLE. Marital status, education, social support, coping, and anxiety were found to be predictors of depression.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Immunology
Changming Chen, Qiulong Yan, Xueming Yao, Shenghui Li, Qingbo Lv, Guangyang Wang, Qin Zhong, Fang Tang, Zhengqi Liu, Ying Huang, Yang An, Jing Zhou, Qiongyu Zhang, Aiqin Zhang, Hayan Ullah, Yue Zhang, Can Liu, Dan Zhu, Hufan Li, Wen Sun, Wukai Ma
Summary: This study analyzed the gut viral community of SLE patients and healthy controls, and found that SLE patients had decreased viral diversity and significant changes in viral composition compared to controls. The gut virome showed high potential in predicting SLE. These findings provide new insights into the pathogenesis and treatment of SLE.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Heming Bai, Lei Jiang, Ting Li, Chong Liu, Xiaoxia Zuo, Yi Liu, Shaoxian Hu, Linyun Sun, Miaojia Zhang, Jin Lin, Weiguo Xiao, Qingwen Wang, Dongbao Zhao, Huaxiang Wu, Xiaodan Kong, Wenkang Gao, Wanxin Hou, Myeongsu Seong, Yuanpeng Zhang, Fangfang Chen, Sheng Chen, Xin Wu, Chunde Bao, Li Wang, Huji Xu
Summary: The study found that air pollutants PM2.5 and NO2 may be risk factors for lupus nephritis (LN), while short-term exposure to CO and O-3 does not generally have an association with LN. Furthermore, negative associations of LN with SO2 were observed for the entire region and east China.
ENVIRONMENTAL RESEARCH
(2021)
Article
Hematology
Leda Coelewij, Kirsty E. Waddington, George A. Robinson, Elvira Chocano, Thomas McDonnell, Filipa Farinha, Junjie Peng, Pierre Donnes, Edward Smith, Sara Croca, Jyoti Bakshi, Maura Griffin, Andrew Nicolaides, Anisur Rahman, Elizabeth C. Jury, Ines Pineda-Torra
Summary: This study found that patients with SLE have global changes in their lipoprotein profiles, but standard serum lipid measurements cannot accurately predict their risk of cardiovascular disease. Serum metabolites may be promising biomarkers to uncover the multi-metabolic phenotypes of subclinical atherosclerosis in SLE patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi, Ninghan Feng
Summary: The microbiome alterations in the gut and oral cavity are associated with the development of systemic lupus erythematosus (SLE). Research on 35 SLE patients revealed reduced bacterial richness and diversity in feces, and increased bacterial diversity in saliva. These findings suggest that different body niches in SLE patients have distinct bacterial profiles that may play a role in the disease development.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Katrine A. Myhr, Amanda H. Zinglersen, Marie-Louise F. Hermansen, Mathies M. Jepsen, Katrine K. Iversen, Anh T. Ngo, Redi Pecini, Soren Jacobsen
Summary: This study aimed to investigate the factors associated with cardiac size and function in SLE patients, and found that the presence of lupus anticoagulant is associated with diastolic dysfunction and left ventricular dilatation during a 5-year follow-up.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Medicine, Research & Experimental
Langxian Zhi, Liyang Gu, Lei Tong, Xuesong Liu, Liangjing Lu, Ruru Guo
Summary: This study aimed to investigate the immune status of systemic lupus erythematosus (SLE) patients with infections. The results showed that SLE patients in the infection group had higher fever and serositis rates, as well as increased levels of neutrophil CD64 (nCD64) expression, myeloid-derived suppressor cells (MDSCs), activated T cells, and multiple cytokines.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)