Article
Dermatology
Elise Boireau-Adamezyk, Arlette Baillet-Guffroy, Georgios N. Stamatas
Summary: The study showed that age and environmental exposure can affect the water content and composition of natural moisturizing factors in the stratum corneum. While the water content decreases with age, the concentrations of various amino acids show species-specific changes. The dynamics of NMF composition may partially explain the age-related changes in SC hydration.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Chemistry, Physical
Yoshihiko Sonoki, Quoc Dat Pham, Emma Sparr
Summary: The barrier function of the skin relies on the outermost layer, the stratum corneum (SC). Adding a mixture of chemicals to the SC has more significant effects than adding single components, increasing the mobility of skin lipids and proteins. This synergistic effect may have implications for the complex mixture of natural moisturizing factor (NMF) in dry conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Allergy
Evgeny Berdyshev, Jihyun Kim, Byung Eui Kim, Elena Goleva, Taras Lyubchenko, Irina Bronova, Anna Sofia Bronoff, Olivia Xiao, Jiwon Kim, Sukyung Kim, Mijeong Kwon, Sungjoo Lee, Yu Jeong Seo, Kyunga Kim, Suk-Joo Choi, Soo-Young Oh, Seung Hwan Kim, So Yeon Yu, Seung Yong Hwang, Kangmo Ahn, Donald Y. M. Leung
Summary: A study found that the risk of developing atopic dermatitis in the future can be predicted by analyzing the skin surface of infants at the age of two months, and identified potential biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Dermatology
A. Samadi, T. Yazdanparast, M. Shamsipour, H. Hassanzadeh, M. Hashemi Orimi, R. Firooz, A. Firooz
Summary: This study conducted a systematic review and meta-analysis on the baseline values of stratum corneum hydration in healthy adults, finding that facial skin has higher hydration levels compared to other areas. There were no statistically significant differences in hydration levels between different age groups and genders.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nikolett Kis, Maria Gunnarsson, Szilvia Berko, Emma Sparr
Summary: The skin provides an attractive alternative to conventional drug administration routes, but the stratum corneum (SC) presents challenges as an efficient barrier to most compounds. This study investigates the molecular effects of three types of glycols in the SC, aiming to understand their influence on molecular mobility and structure, as well as their efficiency as permeation enhancers. The results show that all three glycols increase lipid mobility in the SC and have permeation enhancing effects. There is also a non-monotonic response in permeation enhancement with respect to glycol concentration.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Shogo Takeda, Akari Yoneda, Kenchi Miyasaka, Yoshiaki Manse, Toshio Morikawa, Hiroshi Shimoda
Summary: Ceramide (Cer) is important for skin barrier functions, and ingestion of glucosylceramides (GlcCer) derived from food can reduce transepidermal water loss (TEWL). This study compared the moisturizing effects of 13 GlcCer and 6 Cer isolated from rice in a reconstructed human epidermal keratinization model. Results showed that certain GlcCer and Cer significantly reduced TEWL, and the moisturizing effects of GlcCer were dependent on the length of fatty acids. In addition, elasticamide increased SC Cer contents and GlcCer[d18:2(4E,8Z)/26:0] up-regulated the expression of filaggrin and corneodesmosin, contributing to epidermal hydration. This comparative study revealed differences in the hydration mechanisms of GlcCer and Cer isolated from rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Article
Dermatology
Navlin Naidoo, Anisa Mosam, Georgios Stamatas, Ncoza C. Dlova
Summary: This study compared the skin barrier properties of HIV infected with uninfected infants and found significant differences in TEWL rates and skin hydration between the two groups. The research suggests that the altered skin barrier in HIV infected children may predispose them to various inflammatory and infectious dermatoses. Improving skin barrier function could help prevent these conditions.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Ali Assi, Sana Tfaili, Alessia Quatela, Franck Bonnier, Arlette Baillet-Guffroy, Ali Tfayli
Summary: The study found that UVA and UVB irradiation have an impact on the molecular structure, organization, and barrier function of the stratum corneum, resulting in changes in lipid bilayer organizational order, water content increase, and alterations in protein secondary structure. A UVB dose of 15 mJ/cm(2) was apparently below the threshold for significant changes, despite observed trends.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrej Kovacik, Petra Pullmannova, Lukas Opalka, Michaela Silarova, Jaroslav Maixner, Katerina Vavrova
Summary: The study shows that different types of ceramides play distinct roles in the structural organization and function of the skin lipid barrier, with their effects on lipid models varying depending on the sphingoid base chain and configuration at the alpha-carbon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Shiqiang Cheng, Jiajie Hu, Chen Guo, Zhicheng Ye, Yazhuo Shang, Cheng Lian, Honglai Liu
Summary: Nanoplastics, generated from plastic waste and artificial production, have gained attention due to their wide distribution in the environment and potential risk for humans. This study investigated the interactions between nanoplastics and stratum corneum using Langmuir monolayer and molecular dynamics simulations. The results showed that larger size and surface functionalization of polystyrene nanoplastics significantly reduced the stability of the stratum corneum lipid monolayer. Cell experiments also indicated significant cytotoxicity of functionalized polystyrene nanoplastics on human dermal fibroblast cells, especially amino-modified ones. These findings provide fundamental information for understanding the health risks of nanoplastics.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Dermatology
Norma Cameli, Martina Silvestri, Maria Mariano, Enzo Berardesca
Summary: The study demonstrates that the use of nanosilicon in food supplements and topical solutions can significantly improve skin hydration, elasticity, and barrier function.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Razvigor Darlenski, Dimitar Cherkezov, Ivan Bogdanov
Summary: Exposure to climate conditions in Antarctica can affect skin physiology, particularly in terms of TEWL, erythema, and melanin levels on facial skin. Prolonged contact with exposome factors may result in epidermal barrier impairment and an inflammatory response.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ivan Argatov, Johan Engblom, Vitaly Kocherbitov
Summary: In this study, a new flexible fitting model is introduced to validate the water sorption characteristics of the components in the stratum corneum. The results show that the lipids content has a negligible effect on the sorption of stratum corneum, and the overall sorption behavior can be well explained by the rule of mixtures.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Chemistry, Multidisciplinary
Gregor Germer, Takuji Ohigashi, Hayato Yuzawa, Nobuhiro Kosugi, Roman Flesch, Fiorenza Rancan, Annika Vogt, Eckart Ruehl
Summary: Drug penetration in human skin ex vivo following skin barrier modification was systematically studied using scanning transmission X-ray microscopy. Two methods, employing Beer-Lambert law and singular value decomposition, were compared for analyzing drug concentration data. Results showed that rapamycin did not penetrate the stratum corneum of untreated skin, but penetrated more efficiently after pretreatment with serine protease. The drug mainly associated with corneocytes, with less presence in the intercellular lipid compartment.
