Letter
Dermatology
Suephy C. Chen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Letter
Dermatology
Zhi-Ming Mai, Michael R. Sargen, Rochelle E. Curtis, Ruth M. Pfeiffer, Margaret A. Tucker, Elizabeth K. Cahoon
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Review
Oncology
Michael R. Sargen, Gabriel J. Starrett, Eric A. Engels, Elizabeth K. Cahoon, Margaret A. Tucker, Alisa M. Goldstein
Summary: Sebaceous carcinoma is an aggressive skin cancer with varying survival rates based on disease severity. Its incidence has been increasing in the United States for decades, with unclear reasons. Recent research has provided new insights into the epidemiology, genetics, and tumor biology of this cancer, as well as evidence of a possible viral etiology.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Michael R. Sargen, Ruth M. Pfeiffer, David E. Elder, Xiaohong R. Yang, Alisa M. Goldstein, Margaret A. Tucker
Summary: The study evaluated thickness for first primary melanomas diagnosed in melanoma-prone families and found that participation in a longitudinal surveillance program providing skin cancer screening and education about skin self-exams was associated with thinner melanomas for members of melanoma-prone families. The findings support the clinical benefit of screening (physician and self) for this high-risk population.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Editorial Material
Oncology
Michael R. Sargen, Margaret A. Tucker
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Oncology
Kevin M. Brown, Mai Xu, Michael Sargen, Hyunbum Jang, Mingzhen Zhang, Tongwu Zhang, Bin Zhu, Kristie Jones, Jung Kim, Laura Mendoza, Nicholas K. Hayward, Margaret A. Tucker, Alisa M. Goldstein, Xiaohong Rose Yang, Douglas R. Stewart, Belynda Hicks, Dario Consonni, Angela C. Pesatori, Maria Concetta Fargnoli, Ketty Peris, Alex Stratigos, Chiara Menin, Paola Ghiorzo, Susana Puig, Eduardo Nagore, Thorkell Andresson, Ruth Nussinov, Donato Calista, Maria Teresa Landi
Summary: A novel NRAS variant was identified in an Italian melanoma-prone family, absent in other populations, influencing signaling pathways differently than other RAS activating alterations. Further investigation into NRAS as a familial melanoma gene is warranted.
Article
Obstetrics & Gynecology
Jim Z. Mai, Rui Zhang, Michael R. Sargen, Mark P. Little, Bruce H. Alexander, Margaret A. Tucker, Cari M. Kitahara, Elizabeth K. Cahoon
Summary: This study found that earlier age at menarche and late age at first birth were associated with an increased incidence rate of melanoma. However, other estrogen-related factors and exogenous hormone use were not significantly associated with melanoma incidence.
HUMAN REPRODUCTION
(2022)
Letter
Dermatology
Jessica N. Hatton, Michael R. Sargen, Megan N. Frone, Kelvin C. de Andrade, Sharon A. Savage, Payal P. Khincha
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Michael R. Sargen, Elizabeth K. Cahoon, Kelly J. Yu, Margaret M. Madeleine, Yun Zeng, Judy R. Rees, Charles F. Lynch, Eric A. Engels
Summary: This study characterized the spectrum of nonkeratinocyte skin cancers and identified risk factors in solid organ transplant recipients. The findings suggest that viruses, UV radiation exposure, and immunosuppression are associated with the development of skin cancer in this population.
Article
Oncology
Jim Z. Mai, Cari M. Kitahara, Michael R. Sargen, Mark P. Little, Bruce H. Alexander, Martha S. Linet, Margaret A. Tucker, Elizabeth K. Cahoon
Summary: This study found no significant association between NSAID use and melanoma risk, even in sun-sensitive subgroups.
CANCER PREVENTION RESEARCH
(2022)
Article
Dermatology
Blake E. Vest, Christina L. Harview, Vincent Liu, Brian L. Swick, Kristen G. Berrebi, Shantel Olivares, Mary S. Stone, Michael R. Sargen, Pedram Gerami
Summary: Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described skin tumor with limited cases reported. The tumor is characterized by atypical cells confined to the dermis and subcutis, featuring large vesicular nuclei and abundant eosinophilic cytoplasm. The long-term outcomes of this entity are not yet well-studied, and further research is needed for accurate classification.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Article
Dermatology
Yen T. Luu, Qianlai Luo, Marie-Josephe Horner, Meredith Shiels, Eric A. Engels, Michael R. Sargen
Summary: Antiretroviral therapy may alter susceptibility to nonkeratinocyte skin cancers (NKSCs) by improving immunity in people living with HIV. Incidence rates for various NKSCs were calculated and compared with the general population, and risk factors for NKSCs were evaluated. The study found that the risk for most NKSCs was similar to that of the general population during the antiretroviral therapy era, suggesting that people living with HIV without NKSC risk factors may not require intensive skin surveillance.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Michael R. Sargen, Hildur Helgadottir, Xiaohong R. Yang, Mark Harland, Jessica N. Hatton, Kristine Jones, Belynda D. Hicks, Amy Hutchinson, Michael Curry, Margaret A. Tucker, Alisa M. Goldstein, Ruth M. Pfeiffer
Summary: This study found a relationship between CDKN2A germline pathogenic variants (GPV) and transcript alteration (p16/p14ARF) with increased risk of melanoma, pancreatic cancer, head and neck squamous cell carcinoma, and lung cancer. Combining p16 and p14ARF alteration was associated with increased incidence of esophageal cancer and malignant peripheral nerve sheath tumor.
JNCI CANCER SPECTRUM
(2022)
Meeting Abstract
Dermatology
Y. Luu, A. Goldstein, M. Sargen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Meeting Abstract
Dermatology
Y. T. Luu, Q. Luo, M. Horner, M. Shiels, E. Engels, M. Sargen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)