Article
Biochemistry & Molecular Biology
Young In Lee, Sang Gyu Lee, Jemin Kim, Sooyeon Choi, Inhee Jung, Ju Hee Lee
Summary: The novel emollient containing H.ECMTM liposome shows significant hydration and anti-inflammatory effects, improving skin conditions of dry and eczema-prone skin. The studies confirm its efficacy in reducing itching and restoring skin barrier integrity, making it a therapeutic option for such skin conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Yuriko Sho, Takashi Sakai, Takaoki Sato, Moe Sonezaki, Hidetoshi Taima, Hiroyuki Taguchi, Kazuhiro Kaizu, Takahiro Nishizaka, Yutaka Takagi, Yutaka Hatano
Summary: This study examined the relationship between FLG gene mutations and stratum corneum ceramide profiles during AD remission, and found that the ceramide profile may be a potential biomarker for predicting AD remission or exacerbation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
S. Ziehfreund, L. Tizek, N. Hangel, M-C Fritzsche, S. Weidinger, C. Smith, P. J. Bryce, D. Greco, E. H. van den Bogaard, C. Flohr, J. Rastrick (Ucb), S. Eyerich, A. Buyx, C. Conrad, K. Eyerich, A. Zink
Summary: Chronic inflammatory skin diseases like AD and PSO present significant challenges in healthcare, and it is crucial to research and identify biomarkers for disease progression and treatment response.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Kate Timms, Hui Guo, Peter Arkwright, Joanne Pennock
Summary: Atopic dermatitis is a heterogeneous disorder with a complex etiology. Although keratinocytes are known to play a fundamental role in atopic dermatitis, their contribution to the overall immune landscape in moderate-to-severe cases is still poorly understood. This study investigates the role of keratinocytes in atopic dermatitis and identifies a complex interaction between keratinocytes and immune cells involving the EGF signaling pathway.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: Two 52-week trials showed that treatment with lebrikizumab was effective in improving skin condition and reducing itch severity in patients with moderate-to-severe atopic dermatitis. The incidence of adverse events was generally mild to moderate and did not lead to trial discontinuation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: The study shows that lebrikizumab is effective in treating moderate-to-severe atopic dermatitis in both adolescents and adults, with significant improvements in skin lesions and reduction of itch symptoms during the 16-week induction period.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Dermatology
Sara J. Brown
Summary: GWAS have identified multiple loci associated with atopic dermatitis, confirming existing knowledge and providing new insights, with most risk loci located in intergenic regions with unknown functional mechanisms. Further research is needed to fully understand individual risk.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Jie Han, Xinying Cai, Shichun Qin, Zengyunou Zhang, Yuanyuan Wu, Yuanzhe Shi, Tingyue Deng, Benjin Chen, Li Liu, Haisheng Qian, Wenliang Fang, Fengli Xiao
Summary: TMEM232 promotes keratinocyte inflammation by activating nuclear factor-kappa B and STAT3 pathways to release alarmins and is regulated by the IL-4/STAT6 axis, which exacerbates AD symptoms.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Katrina Abuabara, Sinead M. Langan
Summary: Atopic dermatitis is a common chronic inflammatory skin disease that can occur at any age and has variable patterns of disease activity over time. Genetic factors and parental history of atopy are consistent predictors of more persistent disease. Age-related differences in molecular markers are being studied, although there is a lack of longitudinal data. Preventive measures such as breastfeeding, probiotics, and emollients have shown inconsistent long-term benefits in randomized trials. Future research should focus on disease activity beyond early adulthood and the impact of treatments on long-term outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jihee Kim, Eunjoong Jung, Wonmi Yang, Chun-Kang Kim, Serpen Durnaoglu, In-Rok Oh, Chan-Wha Kim, Anthony J. Sinskey, Martin C. Mihm Jr, Ju Hee Lee
Summary: SPM solution has shown potential as a treatment for inflammatory skin diseases, reducing the expression and release of pro-inflammatory cytokines and improving symptoms and quality of life in individuals with eczema.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger, Constanze Mueller
Summary: Atopic eczema is an inflammatory skin disorder that affects approximately 20% of children worldwide, and early onset can lead to other allergic diseases. Metabolomics can be used to observe the mechanisms of this disease and potentially discover new drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Acoustics
T. Nau, C. Schoenmann, B. Hindelang, L. Riobo, A. Doll, S. Schneider, L. Englert, H. He, T. Biedermann, U. Darsow, F. Lauffer, V. Ntziachristos, J. Aguirre
Summary: Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Current severity assessments rely on visual observation and subjective symptoms. However, optoacoustic mesoscopy has been shown to provide precise biomarkers of inflammation, potentially enabling more accurate evaluations of AD severity.
Article
Dermatology
Anna S. Quaade, Xing Wang, Julie B. K. Solberg, Nina H. Ulrich, Benjamin D. McCauley, Jacob P. Thyssen, Christine Becker, Jeanne D. Johansen
Summary: This study characterized the plasma inflammatory signature of chronic hand eczema (CHE) and found that severe CHE without a history of atopic dermatitis (AD) is associated with systemic Th2-driven inflammation. Targeting type 2 inflammation could be effective in treating various subtypes of CHE.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna Sofia Bronoff, Joanne E. Streib, Kathryn A. Vang, Brittany N. Richers, Patricia Taylor, Lisa Beck, Miguel Villarreal, Keli Johnson, Gloria David, Mark K. Slifka, Jon Hanifin, Donald Y. M. Leung
Summary: This study identified enhanced sphingolipid turnover in the stratum corneum of patients with eczema herpeticum (EH), an increased S1P/ceramide ratio in EH patients' plasma, and elevated SW levels in the plasma of patients with eczema vaccinatum (EV). Downregulation of S1P lyase expression resulted in increased S1P levels and doubled herpes simplex virus 1 (HSV-1) titer in keratinocytes. These findings suggest that the SW signaling system may serve as a biomarker for previous disseminated viral diseases and a potential treatment target in recurring infections.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Dermatology
M. O. Christensen, Y. A. Barakji, N. Loft, C. M. Khatib, A. Egeberg, S. F. Thomsen, J. I. Silverberg, C. Flohr, J. T. Maul, P. Schmid-Grendelmeier, A. S. Halling, I. Vittrup, J. P. Thyssen
Summary: Atopic dermatitis (AD) and food allergy (FA) commonly co-occur and share similar type 2 inflammation. This review aimed to determine the prevalence and bidirectional associations of AD with food sensitivity (FS), FA and challenge-proven food allergy (CPFA). The pooled prevalence of FS, FA, and CPFA in individuals with AD were 48.4%, 32.7%, and 40.7% respectively. The prevalence of FS and FA numerically increased with AD severity, and children with AD had higher prevalences compared to adults with AD. FS, FA, and CPFA are common comorbidities of AD and should be considered in treatment strategies.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Genetics & Heredity
Alessandro Mussa, Chiara Leoni, Matteo Iacoviello, Diana Carli, Carlotta Ranieri, Antonino Pantaleo, Paola Sabrina Buonuomo, Rosanna Bagnulo, Giovanni Battista Ferrero, Andrea Bartuli, Daniela Melis, Silvia Maitz, Daria Carmela Loconte, Antonella Turchiano, Marilidia Piglionica, Annunziata De Luisi, Francesco Claudio Susca, Nenad Bukvic, Cinzia Forleo, Angelo Selicorni, Giuseppe Zampino, Roberta Onesimo, Gerarda Cappuccio, Livia Garavelli, Chiara Novelli, Luigi Memo, Carla Morando, Matteo Della Monica, Maria Accadia, Martina Capurso, Carmelo Piscopo, Anna Cereda, Marilena Carmela Di Giacomo, Veronica Saletti, Alessandro Mauro Spinelli, Patrizia Lastella, Romano Tenconi, Veronika Dvorakova, Alan D. Irvine, Nicoletta Resta
Summary: In this study, the disease heterogeneity of PIK3CA-related overgrowth spectrum (PROS) was explored, and the factors contributing to the diseases were identified. By analyzing 150 new patients and 1007 previously reported mutated patients, a comprehensive picture of the diseases was obtained. The study found that strongly activating PIK3CA variants were mainly present in affected tissues, while weakly activating variants were mainly present in blood. Additionally, strongly activating variants were more common in cases without central nervous system involvement, while weakly activating variants were more associated with central nervous system involvement.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Genetics & Heredity
Sonoko Saito, Noriko Ono, Takashi Sasaki, Satomi Aoki, Kenjiro Kosaki, Bunya Kuze, Kazuhiko Nakabayashi, Masayuki Amagai, Akiharu Kubo
Summary: This article describes a patient with severe early-onset NF2 overlapping with PRS, showing micrognathia, glossoptosis, and a mild form of cleft palate. The patient was found to have a de novo chromosome 22q12 microdeletion including MN1 and NF2.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Allergy
Carol Ni Chaoimh, Dhanis Lad, Claudio Nico, Gerwin J. Puppels, X. F. Colin C. Wong, John E. Common, Deirdre M. Murray, Alan D. Irvine, Jonathan O'Brien Hourihane
Summary: This study has shown that early initiation of daily specialized emollient use can reduce the incidence of atopic dermatitis in high-risk infants during their first year of life.
Article
Allergy
Lucy E. Bradshaw, Laura A. Wyatt, Sara J. Brown, Rachel H. Haines, Alan A. Montgomery, Michael R. Perkin, Sandra Lawton, Tracey H. Sach, Joanne R. Chalmers, Matthew J. Ridd, Carsten Flohr, Joanne Brooks, Richard Swinden, Eleanor J. Mitchell, Stella Tarr, Nicola Jay, Kim S. Thomas, Hilary Allen, Michael J. Cork, Maeve M. Kelleher, Eric L. Simpson, Stella T. Lartey, Susan Davies-Jones, Robert J. Boyle, Hywel C. Williams
Summary: The study found that daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma, or hay fever. The difference in incidence rates of atopic dermatitis, food allergy, asthma, and hay fever between the emollient group and the control group was relatively small.
Article
Medicine, General & Internal
Carleen Walsh, Gerard Leavey, Marian Mc Laughlin, Amy S. Paller, Alan D. Irvine, Fiona Browne, Jemima E. Mellerio, Anthony Bewley
Summary: This study aims to identify a core outcome set for ichthyosis to assess the impact of the disease on patients and caregivers. Through a mixed-method approach, including literature review, qualitative study, and survey, expert opinions and caregiver perspectives will be collected to establish a comprehensive evaluation of ichthyosis.
Letter
Allergy
Alan D. Irvine, Jonathan O'. B. Hourihane, STOP AD Team
Letter
Dermatology
Carsten Flohr, Alan D. Irvine, Michael J. Cork, Eric L. Simpson, Andreas Wollenberg, Mette Deleuran, Amy Praestgaard, Ryan B. Thomas, Ana B. Rossi
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Thomas Bieber, Jacob P. Thyssen, Alan D. Irvine, Yuichiro Tsunemi, Yun-Fei Chen, Luna Sun, Andrea Schloebe, Elisabeth Riedl, Michael J. Cork
Summary: Early improvement in signs and symptoms during treatment with baricitinib can predict clinical response at week 16, offering guidance for dermatologists in selecting treatment strategies for patients with moderate-to-severe AD.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yasuhiko Asahina, Umi Tahara, Satomi Aoki, Kazuhiko Nakabayashi, Chiharu Tateishi, Daisuke Hayashi, Masayuki Amagai, Daisuke Tsuruta, Akiharu Kubo
Summary: A prenatal genetic change on the wild-type allele in an embryo with a congenital pathogenic variant allele can cause superimposed mosaicism of monoallelic and biallelic defect of the gene. We report two HHD cases with superimposed mosaicism: a congenital monoallelic pathogenic variant followed by a postzygotic copy-neutral loss of heterozygosity. Our cases showed that superimposed mosaicism in HHD can occur without a family history and genetic analysis is crucial for evaluating the risk of familial occurrence.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Letter
Dermatology
Keisuke Shimizu, Hideki Fujita, Daisuke Fujisawa, Koremasa Hayama, Satomi Aoki, Akiharu Kubo, Tadashi Terui
JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Tracey T. Sach, Stella Lartey, Charlotte R. Davies, Joanne H. Chalmers, Rachel E. Haines, Lucy A. Bradshaw, Alan S. Montgomery, Kim J. Thomas, Sara J. Brown, Matthew Ridd, Sandra J. Lawton, Mike Cork, Carsten Flohr, Eleanor Mitchell, Richard Swinden, Laura Wyatt, Stella Tarr, Susan Davies-Jones, Nicola M. Jay, Maeve R. Kelleher, Michael J. Perkin, Robert C. Boyle, Hywel Williams, BEEP Study Team
Summary: A study showed that enhancing skin barrier from birth might prevent eczema and food allergy. However, applying emollient daily for the first year of life in high-risk children does not appear cost-effective in preventing atopic eczema.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Letter
Dermatology
Nicole Fagan, Fiona Browne, Veronika Dvorakova, Aine Carroll, Alan D. Irvine
Summary: This study examines the factors influencing the referral process to secondary care among general practitioners and highlights the challenges they face. The results show that most general practitioners are interested in providing care for children with skin diseases locally, but face limitations in access to resources and advice, high demand on dermatology services, and a need for better collaboration between generalists and specialists.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Letter
Dermatology
Ayaka Ariyoshi, Takeshi Fukumoto, Shinya Imamura, Kenichiro Ohnuma, Masako Nishida, Shinya Hashimoto, Hiroshi Nagai, Akiharu Kubo
JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Cathal O'Connor, Vicki Livingstone, Jonathan O'B Hourihane, Alan D. Irvine, Geraldine Boylan, Deirdre Murray
Summary: This large birth cohort study examined the relationship between emollient bathing at 2 months and the trajectory of atopic dermatitis (AD) in the first 2 years of life. The results showed that infants who had emollient baths at 2 months had a higher prevalence of AD, suggesting that early use of emollients may increase the risk of AD.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Dermatology
Umi Tahara, Takeshi Matsui, Toru Atsugi, Keitaro Fukuda, Tommy W. Terooatea, Aki Minoda, Akiharu Kubo, Masayuki Amagai
Summary: This study identifies the expression of hemoglobin a (HBA) in the epidermis and suggests its role as an antioxidant contributing to skin barrier function.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
