Article
Allergy
Nao Tanaka, Masaru Koido, Akari Suzuki, Nao Otomo, Hiroyuki Suetsugu, Yuta Kochi, Kouhei Tomizuka, Yukihide Momozawa, Yoichiro Kamatani, Shiro Ikegawa, Kazuhiko Yamamoto, Chikashi Terao
Summary: This study identified multiple significant susceptibility loci for AD, including both Japanese-specific loci and novel loci shared across different populations. Downstream analyses revealed substantial overlap of GWAS signals in enhancers of skin cells and immune cells, particularly CD4 T cells.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Alicja Majewska, Malgorzata Gajewska, Kourou Dembele
Summary: Canine atopic dermatitis (cAD) is a chronic and recurrent inflammatory skin disorder. Allergen-specific immunotherapy (ASIT) is recognized as an effective treatment for allergies. This study analyzed changes in gene expression in cAD patients after undergoing ASIT. Nine differentially expressed genes related to the dysregulated immune response in cAD patients were identified, and the expressions of five of these genes changed after ASIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Lena Moebus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Huebenthal, Dora Stoelzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Summary: This study explored the blood transcriptomic features of moderate to severe atopic dermatitis (AD). The results showed that AD patients exhibited pronounced inflammatory expression signatures and could be stratified into eosinophilic and noneosinophilic endotypes. Additionally, treatment strategies for the eosinophil-high endotype may require more attention to the restoration of natural killer cell function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Manuel Almenara-Blasco, Jonas Carmona-Pirez, Tamara Gracia-Cazana, Beatriz Poblador-Plou, Juan Blas Perez-Gilaberte, Alba Navarro-Bielsa, Antonio Gimeno-Miguel, Alexandra Prados-Torres, Yolanda Gilaberte
Summary: Patients with atopic dermatitis (AD) have different clinically meaningful comorbidity patterns. The most common comorbidities include respiratory, cardio-metabolic, cardiovascular, and mental health disorders. An infectious respiratory pattern is the most consistent pattern, followed by a cardiometabolic pattern in patients over 18 years of age.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Lena Moebus, Elke Rodriguez, Inken Harder, Agatha Schwarz, Ulrike Wehkamp, Dora Stoelzl, Nicole Boraczynski, Sascha Gerdes, Thomas Litman, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Jochen Schmitt, Thomas Werfel, Stephan Weidinger
Summary: The skin of patients with AD shows dysregulation of NK cells, which is only partially reversed despite clinical improvement under systemic therapy. This may represent a yet underappreciated disease mechanism.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Doreen Siegels, Annice Heratizadeh, Susanne Abraham, Jonas Binnmyr, Knut Brockow, Alan D. Irvine, Susanne Halken, Charlotte G. Mortz, Carsten Flohr, Peter Schmid-Grendelmeier, Lauri-Ann Van der Poel, Antonella Muraro, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: This study critically evaluated systemic treatments for moderate-to-severe AD, with the most reliable and safe trial evidence found for the use of dupilumab in adults for up to 1 year. Limited evidence-based conclusions were drawn for other systemic treatments due to methodological restrictions. Therefore, head-to-head trials with novel systemic treatments are needed to clarify the future role of conventional therapies.
Review
Dermatology
Dan He, Yujie Han, Hongmei Wu, Min Liu, Mao Li, Mao Lu
Summary: The meta-analysis on the use of topical antifungal drugs for treating atopic dermatitis (AD) showed that these drugs are more effective than topical glucocorticoids and the combination of antifungal drugs and glucocorticoids. However, there were no significant differences in adverse reactions among the three groups.
DERMATOLOGIC THERAPY
(2022)
Article
Medicine, General & Internal
Federica Gelato, Luca Mastorino, Ekaterina Stepkina, Giovanni Cavaliere, Simone Ribero, Pietro Quaglino, Michela Ortoncelli
Summary: This retrospective study compares the efficacy of dupilumab therapy in patients with intrinsic and extrinsic atopic dermatitis (AD) and finds no significant differences in treatment outcome between the two groups, suggesting that dupilumab is equally effective regardless of IgE levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Bjorn R. Thomas, Xiang Li Tan, Stefan Van Duijvenboden, Sarah C. Hogan, Aaron J. Hughes, Soha S. Tawfik, Sasha Dhoat, Ravinder Atkar, Elizabeth J. Robinson, Syedia R. Rahman, Samiha Rahman, Rehana A. Ahmed, Rubina Begum, Habiba Khanam, Emma L. Bourne, Eva L. Wozniak, Charles A. Mein, David P. Kelsell, Edel A. O'Toole
Summary: This study explored the phenotype of participants with atopic eczema of Bangladeshi ancestry from East London and investigated the factors associated with LoF FLG variants. The results showed that palm patterns were associated with EASI and TEWL, and the fine perpendicular/prominent diamond patterns could be used as markers for detecting the presence/absence of LoF FLG variants.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Lena Mobus, Elke Rodriguez, Inken Harder, Dora Stolzl, Nicole Boraczynski, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Summary: Skin transcriptome studies in atopic dermatitis have shown core features of disturbed epidermal differentiation and IL-31/IL-1 signaling activation, along with type 2 inflammation, T(H)17 signaling, and natural killer cell function. IL4RA is a key dysregulated gene, and cyclosporine and dupilumab have distinct effects on the transcriptome in AD patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sarita Kanwal, Shanker K. Singh, Sandeep P. Soman, Soumen Choudhury, Priyambada Kumari, Pradeep K. Ram, Satish K. Garg
Summary: In this study, it was found that dogs with AD have significantly higher expression of FLG gene and significantly lower expression of IVL gene in the skin, in addition to significantly increased expression of TNF-alpha, IL-31, and IL-13 genes in their peripheral blood mononuclear cells. These findings suggest that the disruption of skin barrier in dogs with AD may be attributed to the altered expression of FLG and IVL genes, while the clinical manifestations of AD may be associated with the overexpression of TNF-alpha, IL-31, and IL-13 genes. Further studies are needed to confirm these findings and explore the pathogenesis of AD in dogs.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Jaeseung Song, Daeun Kim, Sora Lee, Junghyun Jung, Jong Wha J. Joo, Wonhee Jang
Summary: This study applies integrative genomic and transcriptomic analyses, combined with in silico drug repositioning, to identify alternative therapeutic options for treating atopic dermatitis. The study identifies the transcriptionomic and genomic features of atopic dermatitis and replicates known genetic markers while also discovering new associated genes. By conducting a meta-analysis of transcriptomes from multiple studies, additional susceptibility genes are identified. The study then utilizes connectivity mapping to analyze the chemical or functional properties of these genes. This research provides a comprehensive understanding of the pathophysiologic mechanisms of atopic dermatitis and suggests potential alternative drug candidates for treatment.
COMMUNICATIONS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wanlu Ouyang, Charlene E. Goh, Wei Bo Ng, Fook Tim Chew, Eric Peng Huat Yap, Chin-ying Stephen Hsu
Summary: Atopic dermatitis and tooth developmental abnormalities often occur together in some patients. It is suggested that there may be a common underlying mechanism involving gene mutations and protein interactions. This review explores the key gene mutations and signaling pathways associated with both diseases and identifies a possible association between the Wnt/beta-catenin signaling pathway and desmosomal proteins. Further research is needed to understand the mechanisms driving their co-occurrence and development of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Lena Moebus, Elke Rodriguez, Inken Harder, Nicole Boraczynski, Silke Szymczak, Matthias Huebenthal, Dora Stoelzl, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger
Summary: This study identified blood transcriptomic features of moderate to severe AD patients, stratifying them into eosinophilic and noneosinophilic endotypes. Patients of different endotypes exhibited significant differences in gene expression and clinical manifestations, which may be crucial for designing stratified trial designs and treatment strategies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Oncology
F. Dalenc, V. Ribet, A. B. Rossi, J. Guyonnaud, C. Bernard-Marty, B. de Lafontan, S. Salas, A. -L. Ranc Royo, C. Sarda, N. Levasseur, C. Massabeau, J. -M. Levecq, P. Dulguerova, D. Guerrero, V. Sibaud
EUROPEAN JOURNAL OF CANCER CARE
(2018)
Article
Dermatology
C. Bodemer, E. Bourrat, J. Mazereeuw-Hautier, F. Boralevi, S. Barbarot, D. Bessis, C. Blanchet-Bardon, E. Bourdon-Lanoy, J. -F. Stalder, V. Ribet, D. Guerrero, V. Sibaud
BRITISH JOURNAL OF DERMATOLOGY
(2011)
Article
Dermatology
C. Casas, V. Ribet, S. Alvarez-Georges, V. Sibaud, D. Guerrero, A-M Schmitt, D. Redoules
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2011)
Article
Dermatology
Muriel Bourrain, Virginie Ribet, Audrey Calvez, Philippe Lebaron, Anne-Marie Schmitt
EUROPEAN JOURNAL OF DERMATOLOGY
(2013)
Article
Dermatology
V. Ribet, S. Salas, J. M. Levecq, L. Bastit, M. Alfonsi, G. De Rauglaudre, B. Talon, C. Allavena, C. Miot, J. M. Boisseau, P. Faure
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
(2008)
Article
Dermatology
Brigitte Dreno, Andreas Katsambas, Carlo Pelfini, Daniel Plantier, Eliane Jancovici, Virginie Ribet, Therese Nocera, Pierre Morinet, Amir Khammari
Article
Dermatology
F Poli, V Ribet, C Lauze, H Adhoute, P Morinet
