Article
Biochemistry & Molecular Biology
Zheng Kou, Balun Li, Aili Aierken, Ning Tan, Chenchen Li, Miao Han, Yuanxiang Jing, Na Li, Shiqiang Zhang, Sha Peng, Xianjun Zhao, Jinlian Hua
Summary: The existing treatment modalities for skin injuries, such as dressings, negative-pressure wound treatment, autologous skin grafting, and high-pressure wound treatment, have limitations such as high time cost and inability to remove inactivated tissue in a timely manner. Mesenchymal stem cells (MSCs) have great potential in cell therapy and regenerative medicine due to their unique self-renewal ability and differentiation potential. The addition of collagen to cell cultures promotes cell proliferation and accelerates the healing of skin wounds in mice and canines by promoting epidermal layer repair, collagen deposition, hair follicle angiogenesis, and an inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Min-Yi Ou, Poh-Ching Tan, Yun Xie, Kai Liu, Yi-Ming Gao, Xiao-Sheng Yang, Shuang-Bai Zhou, Qing-Feng Li
Summary: The study discovered that Schwann cells undergo dedifferentiation and upregulation of Wnt signaling during wound healing, with these defects occurring in diabetic patients, but improvement in healing can be achieved through Wnt inhibition and TGF-β3 supplementation. These findings advance the understanding of the roles of neural-derived cells in skin regeneration and suggest potential therapeutic strategies for wound healing disorders.
Article
Cell & Tissue Engineering
Eun Jung Oh, Prakash Gangadaran, Ramya Lakshmi Rajendran, Hyun Mi Kim, Ji Min Oh, Kang Young Choi, Ho Yun Chung, Byeong-Cheol Ahn
Summary: The study demonstrates the potential of fibroblast-derived EVs in promoting wound healing, suggesting they can be utilized for wound healing therapies.
Article
Multidisciplinary Sciences
Oriya Vardi-Yaacov, Adar Yaacov, Shai Rosenberg, Itamar Simon
Summary: Cancer somatic mutations are influenced by multiple mutational and repair processes, some of which are tied to DNA replication. Research shows that late replication timing regions tend to have higher mutation rates (MR), but this association can be affected by different factors. A systematic analysis of nearly 3,000 tumors reveals that about one third of the samples have a weak association between replication timing and mutation rate. These samples exhibit unique mutational signatures and are enriched with mutations in genes involved in DNA replication, repair, and chromatin structure. Surprisingly, tumors with weak associations are found to have genes associated with cell-cell communication and the immune system, suggesting a non-autonomous response to DNA damage.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Raffaella Belvedere, Emanuela Pessolano, Nunzia Novizio, Alessandra Tosco, Daniela Eletto, Amalia Porta, Amelia Filippelli, Francesco Petrella, Antonello Petrella
Summary: The study utilized mesoglycan/lactoferrin for the first time in treating wound healing cell populations, showing enhanced migration, invasion, and differentiation. The combination also promoted the formation of capillary-like structures and inhibited biofilm formation. In vivo analysis confirmed that mesoglycan/lactoferrin promoted skin wound closure in mice and stimulated cell activation for tissue regeneration.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Immunology
Samuel Knoedler, Sonja Broichhausen, Ruiji Guo, Ruoxuan Dai, Leonard Knoedler, Martin Kauke-Navarro, Fortunay Diatta, Bohdan Pomahac, Hans-Guenther Machens, Dongsheng Jiang, Yuval Rinkevich
Summary: Injuries to the skin initiate a series of synchronized healing processes. Fibroblasts play various roles in endogenous wound repair, including activating innate immune cells, depositing scar tissue, and transporting fascial connective tissue to the wounds. Understanding the diversity and versatility of fibroblasts is crucial for deciphering wound pathologies and developing new treatment approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Ana Torres, Liliana Rego, Marcia S. Martins, Marta S. Ferreira, Maria T. Cruz, Emilia Sousa, Isabel F. Almeida
Summary: Skin repair includes epidermal barrier repair and wound healing, involving multiple cellular and molecular stages. To characterize the usage frequency of skin repair ingredients in Portugal's pharmacies and parapharmacies, a comprehensive analysis of the products' composition was conducted. The top three most used cosmetic ingredients were metal salts and oxides, vitamin E and its derivatives, and Centella asiatica extract and actives. Metal salts and oxides were also the most used in medicines, followed by vitamin B5 and derivatives, and vitamin A and derivatives. Silicones and derivatives were the most common skin repair ingredients in medical devices, followed by petrolatum and derivatives, and alginate.
Review
Materials Science, Multidisciplinary
Joseph D. Tanfani, Jasmin D. Monpara, Sriramakamal Jonnalagadda
Summary: 3D printing is widely used by independent researchers in various fields, with 3D bioprinting being a specific form that utilizes bioinks to create complex, bioactive structures such as artificial skin for wound regeneration. Despite the wide range of available materials and cell types, an ideal bioink for printing artificial skin has yet to be found. This review will discuss the different types of 3D printing, commonly used bioinks, challenges in 3D bioprinting of skin, and future directions for the field.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Hector A. Lopez-Munoz, Mauricio Lopez-Romero, Moises A. Franco-Molina, Alejandro Manzano-Ramirez, Cristina Velasquillo, Beatriz Liliana Espana-Sanchez, Ana Laura Martinez-Hernandez, Hayde Vergara-Castaneda, Astrid Giraldo-Betancur, Sarai Favela, Rogelio Rodriguez-Rodriguez, Juan Carlos Mixteco, Juan Carlos Tapia-Picazo, Diana G. Zarate-Trivino, Evgeny Prokhorov, Gabriel Luna-Barcenas
Summary: In this study, we synthesized Au nanoparticles (AuNPs) in chitosan (CTS) solution through chemical reduction of HAuCl4. CTS was further functionalized with glycidyl methacrylate (chitosan-g-glycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cellular regeneration. Our nanocomposites showed excellent cellular viability and had a positive effect on cytokine regulation in the inflammatory and anti-inflammatory response of skin cells. After 40 days, the nanocomposite films exhibited better skin wound healing capacity and cosmetic aspects in comparison with a commercial film and the presence of collagen in the nanocomposite played a significant role in enhancing the overall regeneration effect of skin. Electrical percolation phenomena were utilized to optimize the performance of nanocomposites. Overall, chitosan-based Au nanocomposites showed great potential for skin wound repair.
Review
Biotechnology & Applied Microbiology
Ziyan Zhang, Zhiping Qi, Weijian Kong, Renfeng Zhang, Chunli Yao
Summary: This article reviews the application of MXene in skin wound healing. MXene is a new two-dimensional material with electrical conductivity, antibacterial and photothermal properties, which has a wide range of applications in biomedicine. By introducing the preparation and modification methods of MXene, and systematically summarizing and reviewing the application status and mechanism of MXene in skin wound healing, this review provides guidance for further application of MXene in the design of skin wound dressing to subsequent researchers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Dermatology
Jennifer Jahel Velez Gonzalez, Maximilian Berger, Stefan Schiele, Anna Rubeck, Gernot Mueller, Julia Welzel, Sandra Schuh
Summary: This study investigated the use of D-OCT for evaluating blood vessel morphology and density in venous ulcers and found that it can provide new information about vascular changes during the healing process.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Biochemistry & Molecular Biology
David M. Chesko, Traci A. Wilgus
Summary: This review summarizes the roles of different immune cell types in cutaneous wound healing, with a focus on data from animal studies targeting specific cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Martin Kauke-Navarro, Yuval Rinkevich, Gabriel Hundeshagen, Leila Harhaus, Ulrich Kneser, Bohdan Pomahac, Dennis P. Orgill, Adriana C. Panayi
Summary: Tregs play a critical role in skin wound healing, helping to balance immune homeostasis and promote healthy wound repair. Understanding the function and mechanisms of Tregs is important for understanding wound pathologies and developing new treatment strategies.
MILITARY MEDICAL RESEARCH
(2023)
Review
Medicine, Research & Experimental
Xiaoxue Han, Leah Suyeon Ju, Joseph Irudayaraj
Summary: Oxygen is crucial in regulating various processes in wound healing. However, hypoxia commonly found in wounds can hinder normal healing. To enhance wound healing, oxygenation strategies such as incorporating oxygen delivery materials are effective. This review summarizes the stages of wound healing, the role of hypoxia, and current strategies for incorporating oxygen into wound dressings. The efficacy, mechanisms, and potential benefits and drawbacks of various oxygenation materials are discussed.
MOLECULAR PHARMACEUTICS
(2023)
Review
Polymer Science
Yuan Zhang, Yong Wang, Ying Li, Yunpeng Yang, Mingyuan Jin, Xiaoying Lin, Zeming Zhuang, Kai Guo, Tao Zhang, Weiqiang Tan
Summary: This paper comprehensively reviews the current research and application status of primal hydrogels in the field of skin repair in recent years. Starting from the structure and properties of collagen, the preparation, structural properties, and application of collagen-based hydrogels in skin injury repair are emphatically described. The influences of collagen types, preparation methods, and crosslinking methods on the structural properties of hydrogels are also discussed in detail. The future and development of collagen-based hydrogels are prospected, providing reference for future research and application of collagen-based hydrogels for skin repair.
Letter
Dermatology
Daniel J. Yoon, Chuong Nguyen, Michelle D. Bagood, Daniel R. Fregoso, Hsin-ya Yang, Andrea I. Medina Lopez, Robert W. Crawford, Jennifer Tran, R. Rivkah Isseroff
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Dermatology
Alan Nguyen, Sofia E. Caryotakis, Marilyn Wang, Anthony Gallegos, Michelle D. Bagood, Cordelia Dunai, Guneet Bindra, William J. Murphy, Roslyn Rivkah Isseroff, Athena M. Soulika
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Dermatology
Michelle D. Bagood, Anthony C. Gallegos, Andrea I. Medina Lopez, Vincent X. Pham, Daniel J. Yoon, Daniel R. Fregoso, Hsin-ya Yang, William J. Murphy, R. Rivkah Isseroff
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Evan Austin, Eugene Koo, Alexander Merleev, Denis Torre, Alina Marusina, Guillaume Luxardi, Andrew Mamalis, Roslyn Rivkah Isseroff, Avi Ma'ayan, Emanual Maverakis, Jared Jagdeo
Summary: Red light phototherapy can improve skin fibrosis by regulating extracellular matrices, proliferation, and cellular responses to oxygen-containing compounds. The study found that red light therapy may have anti-fibrotic effects by increasing the expression of MMP1 and PRSS35.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Michelle D. Bagood, R. Rivkah Isseroff
Summary: The study focuses on the role of TRPV1 in skin tissue and its potential value in treating non-healing wounds, providing important insights for future therapies to improve wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Orthopedics
Leo Andrada, Daniel Link, Sara Dahle, Ramanjot Kaur, Yasmin Hadian, R. Rivkah Isseroff
Summary: Penetrating and blunt trauma to the plantar aspect of the foot can lead to arteriovenous fistula. This case report demonstrates the diagnosis of AVF using clinical examination and imaging, and successful treatment with ultrasound-guided laser procedure.
JOURNAL OF FOOT & ANKLE SURGERY
(2022)
Article
Multidisciplinary Sciences
Hsin-ya Yang, Pieter Steenhuis, Aaron M. Glucksman, Zhanna Gurenko, Thi Dinh La, R. Rivkah Isseroff
Summary: The study found that low concentrations of epinephrine can increase the migratory rate of keratinocytes, possibly due to the modulation of cell migration response by α-AR. By blocking A2B-AR, the rapid cell migration induced by low epinephrine can be reversed. This suggests that both A2B-AR and B2AR play a role in mediating keratinocyte migration, with A2B-AR potentially regulating the migration rate under low epinephrine levels.
Article
Biochemistry & Molecular Biology
Andrea I. Medina Lopez, Daniel R. Fregoso, Anthony Gallegos, Daniel J. Yoon, Jaime J. Fuentes, Robert Crawford, Hawa Kaba, Hsin-ya Yang, R. Rivkah Isseroff
Summary: Non-healing wounds are a major medical challenge, and it has been found that beta-adrenergic antagonists can reduce the growth of common wound pathogens and limit biofilm formation. These findings provide new insights for the treatment of chronic skin wounds.
Article
Biochemical Research Methods
Hector Carrion, Mohammad Jafari, Michelle Dawn Bagood, Hsin-ya Yang, Roslyn Rivkah Isseroff, Marcella Gomez
Summary: A deep learning-based image analysis pipeline is developed to efficiently and accurately track the location and size metrics of wounds in experimental animals. The proposed system demonstrates high fidelity results on unseen data and minimal human intervention.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Vincent Falanga, Roslyn Rivkah Isseroff, Athena M. Soulika, Marco Romanelli, David Margolis, Suzanne Kapp, Mark Granick, Keith Harding
Summary: Chronic wounds are wounds that do not heal within an expected time frame due to prolonged dysregulated inflammation. Advances in understanding the cellular and molecular aspects of basic science and innovative treatment modalities have improved the management of chronic wounds. However, gaps still exist in scientific knowledge, highlighting the need for further research to enhance understanding of chronic wounds.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Dermatology
Harrison Shawa, Peggy A. Wu, Sara Dahle, R. Rivkah Isseroff, Apra Sood
Summary: Patients with chronic wounds are at risk of developing allergic contact dermatitis (ACD). Many wound care products contain allergenic ingredients, so it is important for clinicians to be educated about ACD and choose products that minimize allergen exposures.
Article
Cell Biology
Harrison J. Shawa, Sara E. Dahle, Roslyn Rivkah Isseroff
Summary: Venous leg ulcers, the most common type of leg ulcer, occur in patients with chronic venous insufficiency due to venous hypertension. This study found that average compression was higher in dermatology wound clinics compared to general surgery clinics, and the type of compression device used also affected the pressure applied. Standardization in training and increased use of pressure monitoring may improve the consistency and efficacy of compression treatment in patients with chronic venous insufficiency.
WOUND REPAIR AND REGENERATION
(2023)
Meeting Abstract
Cell Biology
Moyasar A. Alhamo, Hsin-Ya Yang, Anthony Gallegos, Harrison Shawa, Daniel R. Fregoso, Andrea Medina Lopez, Athena M. Soulika, Roslyn Rivkah Isseroff
WOUND REPAIR AND REGENERATION
(2023)
Article
Multidisciplinary Sciences
Anthony Gallegos, Roslyn Rivkah Isseroff
Summary: This paper reports a simple and efficient method for the concurrent analysis of neuroactive compounds in mouse serum. These compounds are of interest in mood and behavior studies and serve as biomarkers for neuroendocrine tumors. The method demonstrated good performance and was successfully applied in rodent experiments.
Article
Multidisciplinary Sciences
Brett Sargent, Mohammad Jafari, Giovanny Marquez, Abijeet Singh Mehta, Yao-Hui Sun, Hsin-ya Yang, Kan Zhu, Roslyn Rivkah Isseroff, Min Zhao, Marcella Gomez
Summary: The article introduces a machine learning model that can predict the direction of cell migration based on the time series of electric field values and directedness. This method is highly adaptable to different cell types and experimental conditions and can achieve accurate predictions with limited training data.
SCIENTIFIC REPORTS
(2022)
