Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 130, Issue 3, Pages 645-647Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/jid.2009.378
Keywords
-
Categories
Funding
- NATIONAL CANCER INSTITUTE [ZIABC010784] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Most hypopigmenting reagents target the inhibition of tyrosinase, the key enzyme involved in melanin synthesis. In this issue, Choi et al. report that NADPH:quinone oxidoreductase-1 (NQO1) increases melanin synthesis, probably via the suppression of tyrosinase degradation. Because NQO1 was identified by comparing normally pigmented melanocytes with hypopigmented acral lentiginous melanoma cells, these results Suggest various hypotheses regarding the carcinogenic origin of the latter.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available