Article
Dermatology
Jean Kanitakis
Summary: Circumscribed palmoplantar hypokeratosis is a rare acquired dermatosis mainly affecting middle-aged or elderly women, presenting clinically with sharply limited, annular erythematous plaques. Despite its characteristic clinical and microscopic features, the pathogenesis and treatment of the disease remain unclear.
CLINICS IN DERMATOLOGY
(2021)
Article
Dermatology
Juan Torre-Castro, Laura Najera, Irene Salgueero, Luis Requena
Summary: Circumscribed palmar or plantar hypokeratosis is a focal disorder of keratinization that may result in focal epidermal dysplasia.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Infectious Diseases
Elias Quintero-Munoz, Daniel Martin Arsanios, Maria Fernanda Estupinan Beltran, Juan David Vera, Catalina Palacio Giraldo, Omar Velandia, Carlos Mauricio Calderon
Summary: This case report describes the first reported case of palmoplantar keratoderma associated with human lymphotropic virus infection. This new clinical manifestation should be considered in patients with dermatological characteristics in endemic areas. The symptoms were managed effectively with dermal hydration and skin care.
BMC INFECTIOUS DISEASES
(2021)
Review
Dermatology
Tugba Atak, Muzeyyen Gonul, Leyla Magsudova, Aysun Gokce, Selda Pelin Kartal
Summary: Circumscribed palmar or plantar hypokeratosis (CPPH) is a newly defined dermatologic disorder that may be more common than expected and has a potential risk of malignant transformation.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Article
Medicine, General & Internal
Erica Aukerman, Megana Rao, Azadeh Samiei, Maria C. Bell, Sahand Rahnama-Moghadam
Summary: A man in his late 70s with a history of psoriasis and non-melanoma skin cancer presented with a progressive rash on his right thenar eminence. After unsuccessful topical treatment, a shave biopsy confirmed the presence of circumscribed palmar hypokeratosis and central actinic keratosis. Treatment with 5-fluorouracil and calcipotriene cream resulted in near-complete resolution of the rash, suggesting a potential novel treatment option for patients with concomitant actinic keratosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Dermatology
Federico Bardazzi, Giuseppe Gallo, Camilla Loi, Cosimo Misciali, Annalisa Patrizi, Andrea Filippini
Summary: Palmo-plantar lesions in discoid lupus erythematosus (DLE) are considered a rare condition that is often refractory to conventional treatments. This case report suggests that therapy with mycophenolate mofetil (MMF) may be an effective and safe approach for managing refractory palmo-plantar DLE.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Giulia Pavia, Luigi Gargiulo, Andrea Cortese, Mario Valenti, Federica Sanna, Riccardo G. Borroni, Antonio Costanzo, Alessandra Narcisi
Summary: Apremilast showed high efficacy and safety in the treatment of non-pustular palmoplantar psoriasis, with the majority of patients showing significant improvement at week 16 without any major safety issues reported.
DERMATOLOGIC THERAPY
(2022)
Article
Medicine, General & Internal
Tang Yang, Qiao Deng, Shuai Jiang, Yu-Ying Yan, Ye Yuan, Si-Miao Wu, Shu-Ting Zhang, Jia-Yu Sun, Bo Wu
Summary: Single subcortical infarction (SSI) is caused by two main etiological subtypes, branch atheromatous disease (BAD) and cerebral small vessel disease (CSVD)-related SSI. This study found that patients with BAD were more likely to perform worse in language, attention, executive function, and memory compared to those with CSVD-related SSI, even after adjusting for age, years of education, National Institutes of Health Stroke Scale, and lesion location.
CHINESE MEDICAL JOURNAL
(2021)
Article
Dermatology
Eran Cohen-Barak, Wassim Azzam, Jennifer L. Koetsier, Nada Danial-Farran, Moran Barcan, Maysa Hriesh, Morad Khayat, Natalia Edison, Judith Krausz, Chen Gafni-Amsalem, Akiharu Kubo, Lisa M. Godsel, Michael Ziv, Stavit Allon-Shalev
Summary: Acral peeling skin syndrome (APSS) is a heterogeneous group of genodermatoses, with some cases caused by mutations in SERPINB7 gene leading to unopposed protease activity and enhanced epidermal desquamation. This study found that loss of SERPINB7 function disrupts desmosomal components, contributing to skin peeling alongside stratum corneum perturbation.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Psychology, Multidisciplinary
Christian Kissler, Christin Schwenk, Joerg-Tobias Kuhn
Summary: The study identified two subtypes in individuals with dyscalculia, with differences mainly in mathematical abilities and possibly in attention. Intelligence differences were not significant between subtypes, while working memory and reading fluency were found to have negligible differences. The results appeared to be robust regardless of the diagnostic test used.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Immunology
Chenglin Ye, Sizhe Zhu, Jingping Yuan
Summary: This study analyzed the gene expression profiles of patients with Crohn's disease (CD) and identified two gene subtypes: immune and metabolic. The immune subtype was associated with leukocyte migration and cytokine interactions, while the metabolic subtype was associated with metabolic pathways. The combination of interleukin 1 beta, interleukin 6, and Toll-like receptor 4 effectively distinguished between these two gene subtypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Alexis Brierty, Christopher P. Carty, Claudia Giacomozzi, Teresa Phillips, Henry P. J. Walsh, David Bade, Sean Horan
Summary: This study aimed to describe normative reference values of regional plantar load and compare them with two pathological case studies, finding clear differences in the load transfer phase of gait. The findings highlight the clinical significance of the load transfer phase of gait for intervention planning.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Kailin Liu, Lili Guo, Yong Cheng, Jianhong Liang
Summary: In this study, concentrations of various cytokines in the aqueous humor of eyes with circumscribed choroidal hemangioma (CCH) were compared with a control group. Results showed higher concentrations of VEGF-A and IP-10 in CCH patients, indicating their involvement in the angiogenic and antiangiogenic processes. This provides new insights into the pathophysiology of CCH and suggests potential targets for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Bi-Ling Huang, Min Tan, Ming-Liu Li, Yuan-Yuan Teng, Min Zhou, Min Wang
Summary: Malignant melanoma originating from melanocytes is a highly malignant tumor with poor prognosis, rarely occurring on the foot. Among the chronic complications of diabetes, diabetic foot ulcer is one of the most serious. This paper presents two cases of type 2 diabetes patients with malignant melanoma on the foot. Clinicians should enhance understanding of diabetic patients with acral malignant melanoma. Prompt pathological biopsy of cutaneous lesions should be performed when diabetic foot ulcers persist and do not heal, to avoid missed diagnosis and improve survival rate.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Multidisciplinary
Xiuming Li, YuJie Li, Runqi Chen, Jinling Chi, Xianjin Shi, Hu Lin
Summary: The paper proposes a chord-angle evaluation condition based on the chord and its two corresponding minimum angles to solve the minimum circumscribed circle problem. By transforming these conditions into corresponding operators, computational efficiency is improved. Experimental results demonstrate that the algorithm can accurately and effectively determine the minimum circumscribed circle in different data point scenarios.
