Article
Integrative & Complementary Medicine
Yeliz Dogan Merih, Aysegul Aliogullari, Dilek Coskuner Potur
Summary: The study found that using vernix caseosa is more effective than mother's milk in preventing postpartum nipple problems. Mothers in the vernix caseosa group had reduced pain and rashes, increased satisfaction, and no nipple cracks by the seventh day.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Marty O. Visscher, Andrew N. Carr, Vivek Narendran
Summary: The development of fetal skin barrier and the immunity of neonatal skin play important roles in protecting against environmental effects and promoting rapid barrier development after birth. Neonatal skin exhibits differences in protein biomarkers, gene expression, and biological processes compared to adult skin, suggesting its unique ability to support the newborn's survival and growth.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Food Science & Technology
Weidi Li, Liang Jie, Renqiang Yu, Qingzhe Jin, Shanyu Jiang, Qitao Yin, Wei Wei, Xingguo Wang
Summary: BCFA were found in breast milk, vernix caseosa, and meconium. Vernix caseosa contained nine BCFA, with the highest content in iso-16:0, while meconium did not contain five BCFA. The concentration of BCFA in vernix caseosa was significantly higher in full-term infants compared to preterm infants.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Tao Wang, Nana She, Mengnan Wang, Bo Zhang, Jiaxing Qin, Jingyuan Dong, Guozhen Fang, Shuo Wang
Summary: Storage temperature has a significant impact on the physicochemical properties and qualities of red brown rice, affecting factors such as free fatty acid values, pH of residual cooking water, adhesiveness, hardness, and heating water absorption rate. Low temperatures can delay changes in these properties by slowing down molecular movements and enhancing molecular bonds. Additionally, storage duration affects water molecule migration and protein structure, with low temperatures retarding these changes.
Article
Food Science & Technology
Wenqing Yang, Qiming Wang, Yuanyuan Chen, Lin Lei, Xiaojuan Lei, Jichun Zhao, Yuhao Zhang, Jian Ming
Summary: This study investigated the structure and physicochemical properties of wheat gliadin and maize amylopectin conjugates induced by the Maillard reaction (MR) at different ratios. It was found that the conjugates produced under different ratios had varying degrees of improved functional properties and reduced allergenicity. The study provides valuable insights into the potential industrial application of gliadin-based products.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Food Science & Technology
Keying Han, Xiao Feng, Yuling Yang, Xiaozhi Tang, Chengcheng Gao
Summary: Microfluidization is an effective technology to improve the properties of myofibrillar protein. The study investigated the effects of microfluidization with varying pressures on the physicochemical, structural, and emulsifying properties of chicken myofibrillar protein. Microfluidization treatment enhanced the zeta-potential, contact angle, solubility, emulsifying ability, and emulsifying stability of the protein, while decreasing its turbidity. The treatment also resulted in structural changes and the exposure of hydrophobic and negatively charged groups.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2023)
Article
Chemistry, Applied
Qian Ju, Yanqiu Yuan, Chang Wu, Yayun Hu, Shuyi Zhou, Guangzhong Luan
Summary: This study revealed the thermal aggregation nature of soybean protein at the subunit level. The research found that beta-conglycinin, alpha alpha'-subunits, and acidic polypeptide formed regular thermal aggregates with high solubility, high zeta-potential value, and small particle size. In contrast, glycinin, beta-subunit, and basic polypeptide aggregated into insoluble clusters with large particle size distribution.
Article
Optics
Mithun Bhowmick, Jacob Fryman, Xuan Zhou, Chari Ramkumar
Summary: Laser-driven hypervelocity impact experiments were conducted to investigate the long-term effects of pressure on the crystal structure of undoped GaSb. X-ray diffraction and confocal micro-Raman spectra were used to analyze unshocked and shock-compressed samples, with pressures ranging from 8 to 23 GPa. The results showed that GaSb remained crystalline at 8 GPa but exhibited localized site disordering, transitioned to an amorphous state at 13 GPa, and maintained that phase until 23 GPa.
Article
Chemistry, Applied
Dong-Hui Geng, Xiaojun Zhang, Chongyang Zhu, Chen Wang, Yongqiang Cheng, Ning Tang
Summary: The effects of different preheating temperatures and pullulanase treatments on the properties of rice starch were investigated. Preheating at 60, 70, and 80 degrees Celsius resulted in starches with strong, medium, and weak gel strength respectively. Increasing the preheating temperature led to a decrease in gel strength and increased resistance to enzyme digestion.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Izabela Barszczewska-Rybarek, Katarzyna Jaszcz, Grzegorz Chladek, Paulina Grabowska, Agnieszka Okseniuk, Michalina Szpot, Magdalena Zawadzka, Aleksandra Sokolowska, Aleksandra Tarkiewicz
Summary: The study aimed to identify the qualitative and quantitative changes in the closed cell rigid PU foam when heated in air and seawater, predicting its performance and durability. Aging caused yellowing of the samples and irregularity in foam pores. Heating at 80 degrees C showed more significant changes compared to 40 degrees C, including an increase in glass transition temperature, water absorption, and a decrease in strength.
Article
Obstetrics & Gynecology
Gul Nihal Buyuk, Z. Asli Oskovi-Kaplan, Serkan Kahyaoglu, Yaprak Enign-Ustun
Summary: This study found that in the third trimester, the presence of echogenic particles in amniotic fluid may be associated with the gender of the newborn, but not with meconium. The presence of echogenic particles in the amniotic fluid of pregnant women does not seem to have a direct relationship with adverse perinatal outcomes, but the primary cesarean section rate may require additional attention.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Multidisciplinary Sciences
Tyler W. Iorizzo, Peter R. Jermain, Elena Salomatina, Alona Muzikansky, Anna N. Yaroslavsky
Summary: This study found significant differences in the optical properties of skin at different temperatures, with absorption and scattering coefficients increasing and anisotropy factors decreasing with temperature. Changes in absorption coefficients indicated deoxygenation of hemoglobin and a blue shift of water absorption bands.
SCIENTIFIC REPORTS
(2021)
Article
Acoustics
Xiaoyan Hou, Xiaowan Li, Jianlong Li, Jun Cong, Lingyan Jiang, Guanghui Shen, Anjun Chen, Zhiqing Zhang
Summary: This study investigated the effects of ultrasound treatment on the physicochemical properties of potato flour. The results showed that ultrasound treatment decreased the blue value and oil holding capacity while increasing the swelling power, water solubility, syneresis rate, and transparency of the potato flour. Additionally, ultrasound treatment also altered the thermal properties, morphology, and crystallinity of the sonicated flour. These findings have important implications for the industrial applications of potato flour.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Food Science & Technology
Ji'en Tan, Tiantian Liu, Yao Yao, Na Wu, Huaying Du, Mingsheng Xu, Mingfu Liao, Yan Zhao, Yonggang Tu
Summary: The Maillard reaction was found to occur in egg white during alkali treatment, with color intensity and browning intensity increasing while pH decreased with extended incubation days. The antioxidant activities of Maillard reaction products peaked on the first day of incubation before decreasing with longer incubation periods. Temperature had a significant impact on the physicochemical properties of egg white and the antioxidant activities of Maillard reaction products during alkali treatment.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Jing Peng, Kexue Zhu, Xiaona Guo, Wei Peng, Yuan Chen, Qin Li, Huiming Zhou
Summary: The study focused on the effect of various concentrations of sodium chloride on the physicochemical and structural properties of extruded wheat gluten. The addition of NaCl influenced the hardness, chewiness, resilience, protein polymerization, and microstructure of the extrudates. Different concentrations of NaCl resulted in varied effects on the textural properties and protein aggregation of the extrudates.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Robert Rissmann, Matthijs Moerland, Martijn B. A. van Doorn
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
Tessa Niemeyer-van der Kolk, Hein van der Wall, Geretta K. Hogendoorn, Rianne Rijneveld, Sascha Luijten, Dirk C. J. G. van Alewijk, Ellen H. A. van den Munckhof, Marieke L. de Kam, Gary L. Feiss, Errol P. Prens, Jacobus Burggraaf, Robert Rissmann, Martijn B. A. van Doorn
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2020)
Article
Medicine, Research & Experimental
Hendrika W. Grievink, Silvana M. G. Jirka, Tess D. Woutman, Mascha Schoonakker, Robert Rissmann, Karen E. Malone, Gary Feiss, Matthijs Moerland
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2020)
Article
Pharmacology & Pharmacy
Mahdi Saghari, Pim Gal, Dimitrios Ziagkos, Jacobus Burggraaf, John F. Powell, Nuala Brennan, Robert Rissmann, Martijn B. A. van Doorn, Matthijs Moerland
Summary: The study demonstrated an increase in anti-KLH antibodies after KLH immunization and a delayed-type hypersensitivity response after intradermal KLH administration. This suggests that the KLH model could serve as an objective tool for studying the pharmacodynamics of T-cell-directed immunomodulatory drugs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Dermatology
Tessa Niemeyer-van der Kolk, Thomas P. Buters, Lara Krouwels, Jiry Boltjes, Marieke L. de Kam, Hein van der Wall, Dirk C. J. G. van Alewijk, Ellen H. A. van den Munckhof, Martin J. Becker, Gary Feiss, Edwin F. Florencia, Errol P. Prens, Matthijs Moerland, Jacobus Burggraaf, Robert Rissmann, Martijn B. A. van Doorn
Summary: Omiganan restored dysbiosis by reducing Staphylococcus abundance and increasing diversity. However, there was no significant clinical improvement observed.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Justin Jacobse, Wouter ten Voorde, Anushka Tandon, Stefan G. Romeijn, Hendrika W. Grievink, Koen van der Maaden, Michiel J. van Esdonk, Dirk Jan A. R. Moes, Floris Loeff, Karien Bloem, Annick de Vries, Theo Rispens, Gertjan Wolbink, Marieke de Kam, Dimitrios Ziagkos, Matthijs Moerland, Wim Jiskoot, Joke Bouwstra, Jacobus Burggraaf, Lenneke Schrier, Robert Rissmann, Rebecca ten Cate
Summary: This study evaluated the feasibility of intradermal administration of adalimumab using hollow microneedles. It was found that intradermal adalimumab injection was perceived as more painful compared to subcutaneous administration, but resulted in higher relative bioavailability and skin reactions. The study also showed similar safety and pharmacokinetic effects between intradermal and subcutaneous administration routes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Robert Rissmann, Rob Zuiker
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter W. Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter Ten Voorde, Edwin Florencia, Michelle Osse, Marieke L. de Kam, Hendrika W. Grievink, Mascha Schoonakker, Amit A. Patel, Simon Yona, Derek W. Gilroy, Erik Lubberts, Jeffrey Damman, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: This study aimed to characterize the intradermal LPS response in healthy volunteers as a local inflammation model for clinical pharmacology studies. Results showed that intradermal LPS administration induced a visible response, with acute interleukin and tumor necrosis factor protein response followed by different cellular responses. The study suggests that intradermal LPS administration may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory compounds.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter ten Voorde, Hendrika W. Grievink, Mascha Schoonakker, Marieke L. de Kam, Derek W. Gilroy, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: In this study, the inhibitory effects of oral and topical corticosteroid treatment on intradermal lipopolysaccharide (LPS) responses were evaluated. The results showed that corticosteroids significantly suppressed the clinical inflammatory response and reduced the secretion of inflammatory mediators. This experimental model is effective in evaluating the effects of anti-inflammatory drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Mahdi Saghari, Pim Gal, Sally Gilbert, Martin Yateman, Ben Porter-Brown, Nuala Brennan, Sonia Quaratino, Rosamund Wilson, Hendrika W. Grievink, Erica S. Klaassen, Kirsten R. Bergmann, Jacobus Burggraaf, Martijn B. A. van Doorn, John Powell, Matthijs Moerland, Robert Rissmann
Summary: The safety, tolerability, immunogenicity, and pharmacokinetic profile of anti-OX40L monoclonal antibody KY1005 were evaluated, and its effects on antibody response and skin response were observed. The study found that KY1005 demonstrated an acceptable safety and tolerability profile, showed pharmacological activity, and had potential as a novel pharmacological treatment for immune-mediated disorders.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Bertine W. Huisman, Merve Cankat, Tjalling Bosse, Alexander L. Vahrmeijer, Robert Rissmann, Jacobus Burggraaf, Cornelis F. M. Sier, Mariette I. E. van Poelgeest
Summary: Fluorescence-guided surgery using integrin alpha v beta 6 as a target showed robust discrimination of vulvar tumors and surrounding tissue, suggesting its potential utility in future studies. Immunohistochemistry of membrane proteins identified possible tracers for fluorescence-guided surgery in vulvar (pre)malignancies, emphasizing the need for further evaluation of alpha v beta 6 as a target.
Review
Microbiology
Lisa Pagan, Roos A. M. Ederveen, Bertine W. Huisman, Jan W. Schoones, Romy D. Zwittink, Frank H. J. Schuren, Robert Rissmann, Jurgen M. J. Piek, Mariette I. E. van Poelgeest
Summary: This systematic review explores the relationship between microbiome and vulvar (pre)malignant disease, revealing differences in vulvar microbiome composition between healthy and diseased states. Although promising, there is limited data with low evidence levels.
Review
Pharmacology & Pharmacy
Laura M. de Jong, Sylvia D. Klomp, Nicoline Treijtel, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Summary: This systematic review aimed to evaluate the risk of disease-drug-drug interactions (DDDIs) caused by immunomodulating drugs and summarize the relevant information in FDA/EMA approved drug labeling. The results showed that the DDDI risk of immunomodulating drugs is specific to target and disease.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Editorial Material
Dermatology
Deepak M. W. Balak, Robert Rissmann
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Bertine W. Huisman, Lauren E. H. Nene, Feeke L. L. Linders, Tom K. Gambrah, Tessa Niemeyer van Der Kolk, Marieke L. de Kam, Jan Nico Bouwes Bavinck, Jacobus Burggraaf, Gary Feiss, Robert Rissmann
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)