Article
Immunology
Xiao-Xue Zhang, Jun-Peng You, Xin-Ran Liu, Ya-Fei Zhao, Yan Cui, Zhan-Zheng Zhao, Yuan-Yuan Qi
Summary: This study provides new evidence for the association between variants located in lncRNA coding genes and susceptibility to SLE. Additionally, the study found elevated expression levels of the PRDX6 gene in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yanli Ren, Enyu Tong, Chunhong Di, Yunheng Zhang, Liangwen Xu, Xiaohua Tan, Lei Yang
Summary: This study examined the association between single-nucleotide polymorphisms in the ABCA1 gene and hypertension in Chinese Han adults. The results showed significant associations between certain genotypes and hypertension, as well as specific haplotypes and blood pressure measures.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Yanmei Ruan, Jinwei Zhang, Shiqi Mai, Wenfeng Zeng, Lili Huang, Chunrong Gu, Keping Liu, Yuying Ma, Zhi Wang
Summary: Genetic factors and gene-environment interaction play an important role in the development of noise induced hearing loss (NIHL). Certain genetic polymorphisms in the CASP7 gene are associated with increased risk of NIHL, while some genotypes can reduce the risk. Workers carrying high-risk genotypes are at a higher risk of developing NIHL.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Summary: Genetic studies have linked the rs10947540 single-nucleotide polymorphism (SNP) in the ZNF76 gene with susceptibility to systemic lupus erythematosus (SLE) in Chinese populations. Carrier individuals of the C allele of rs10947540 were found to have a higher risk of developing SLE with elevated levels of serum creatinine. Bioinformatic analysis revealed a correlation between this SNP and decreased expression of ZNF76, suggesting a potential role in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mengni Wang, Chang Peng, Hongjuan Chang, Mengying Yu, Fajuan Rong, Yizhen Yu
Summary: This study reveals the interaction between SIRT1 gene and childhood maltreatment on aggressive behavior among Chinese adolescents. The minor allele of SIRT1 rs4746720 shows a protective effect on reducing aggression risk when combined with childhood maltreatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Chun Luo, Chongyu Hu, Bingyang Li, Junyu Liu, Liming Hu, Rui Dong, Xin Liao, Jilin Zhou, Lu Xu, Songlin Liu, Yifeng Li, Dun Yuan, Weixi Jiang, Junxia Yan
Summary: The study found that LOX and LOXL2 gene polymorphisms were associated with the risk of single IA and multiple IA in a Chinese population, while SNPs of LOXL1, LOXL3, and LOXL4 were not associated with IA risk. Further investigation is needed to understand the effects of these genes on IA.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Shouxiang Xu, Boshen Wang, Lei Han, Yuepu Pu, Baoli Zhu, Juan Zhang
Summary: This study investigated the relationship between genetic polymorphisms in the FAS gene and noise-induced hearing loss (NIHL) risk among Chinese workers exposed to occupational noise, and found that genetic polymorphisms in the FAS gene are related to the risk of NIHL in the Chinese population. Noise exposure can lead to the generation of reactive oxygen species, causing oxidative stress, lipid peroxidation, DNA damage, and ultimately activating the FAS gene, leading to hearing loss.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Virology
Zepei Feng, Peng Huang, Jinwei Zhang, Xueshan Xia, A-mei Zhang, Tian Zeng, Qiong Chen, Chuanlong Zhu, Weilong Tan, Yun Zhang, Ming Yue
Summary: The genetic variants of KIR2DL4 and HLA-G are associated with susceptibility to hepatitis C virus infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Dermatology
Rehab Mohammed Salem, Amira Mohamed Noureldin Abdelrahman, Heba Mohamed Abd El-Kareem, Marwa Seif
Summary: The study found that DEFB1 gene polymorphisms are associated with the risk of vitiligo development, the extent of the disease, and the response to NB-UVB treatment. The AA genotype of (-20G/A) is protective against vitiligo development, while the GG genotype and G allele of (-44 C/G) increase the risk. Different DEFB1 gene polymorphisms may modify the risk of vitiligo development, disease extent, and response to NB-UVB phototherapy.
DERMATOLOGIC THERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mingming Li, Yuhan Zhang, Aopeng Zhang, He Cai, Rui Zhang, Ran Cheng, Tao Hu
Summary: This study found that single gene polymorphisms in A20 and IL-10 genes were not associated with the risk of periodontitis. NF-kappa B1 gene polymorphism indirectly affects susceptibility to periodontitis. The combined effect of anti-inflammatory gene polymorphisms (A20 and IL-10) correlated with the decreased risk of periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Oncology
Liang Li, Xingchen Meng, Liyuan Liu, Yujuan Xiang, Fei Wang, Lixiang Yu, Fei Zhou, Chao Zheng, Wenzhong Zhou, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shiguang Zhu, Wenshu Zuo, Chunmiao Ye, Gengshen Yin, Zhongbing Ma, Shuya Huang, Zhigang Yu
Summary: The study showed that polymorphisms rs1137101 and rs4655555 in the LEPR gene can decrease the risk of breast cancer in Chinese females, potentially serving as a research-worthy bio-diagnostic marker for early prediction and risk assessment of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin, Fulin Chen
Summary: This study assessed the correlation between single nucleotide polymorphisms (SNPs) in DNA repair genes and the risk of lung cancer. The results showed that a SNP in the RAD54L2 gene increased the risk of lung cancer, and different SNPs showed associations with lung cancer risk in different age, smoking, and drinking groups. These findings may contribute to a better understanding of the impact of genetic polymorphisms on lung cancer occurrence.
Article
Biochemistry & Molecular Biology
Xu Chao, Jieqiong Wu, Wei Zhang, Xuesong Feng, Luyan Zhao, Feng Huang, Chao Jiang
Summary: The study indicates that STAT4 rs11889341 is significantly associated with HCC risk across multiple genetic models in the Chinese Han population, showing a potential link. Additionally, two other SNPs (rs7574865 and rs10174238) are also associated with HCC risk in specific subgroups.
BIOSCIENCE REPORTS
(2021)
Article
Multidisciplinary Sciences
Yan Wang, Zhiyuan Qiu, Guangyu Tian, Qianqian Zhu, Zhao Zhang, Rong Qin, Yong Peng, Weifeng Tang, Sheng Zhang, Yan Xi
Summary: Long non-coding RNAs (LncRNAs) and their single nucleotide polymorphisms (SNPs) have important roles in tumor development, with rs944289 potentially associated with decreased risk of colorectal cancer (CRC) in the Chinese Han population.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jiaming Chang, Lei Lin, Chunlei Zhou, Xinxin Zhang, Tianyou Yang, Haiyan Wu, Yan Zou, Jing He
Summary: Common genetic mutations are absent in neuroblastoma, but TET1 gene polymorphisms are significantly associated with increased neuroblastoma risk. The rs3998860 G > A and rs12781492 A > C polymorphisms are closely related to increased risk, and they have an impact on the expression of STOX1 mRNA. Further research is required for the potential mechanism and therapeutic prospects in neuroblastoma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)