Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 40, Issue 5, Pages 1670-1676Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/030006051204000506
Keywords
TYPE 2 DIABETES; CAROTID PLAQUE; VASPIN
Funding
- Ministry of Science and Technology of the People's Republic of China [2001BA702B01]
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OBJECTIVE: To examine whether there is an association between the serum concentration of vaspin and the presence of carotid plaque in early stage type 2 diabetes mellitus (T2DM). METHODS: Patients (n = 61) with T2DM within 3 years of diagnosis were divided into those with and those without carotid plaque. Fasting serum vaspin levels, measured by enzyme-linked immunosorbent assay, and blood pressure were compared between these two groups and also with an age-matched, apparently healthy control group (n = 26). RESULTS: Fasting serum vaspin concentrations were significantly higher in patients with T2DM without carotid plaque than in controls, but significantly lower in T2DM patients with carotid plaque than in those without. Multivariate logistic regression analysis showed a significant positive association between the presence of carotid plaque and systolic blood pressure and a significant inverse association between the presence of carotid plaque and fasting serum vaspin concentration. CONCLUSION: A significant inverse association was found, in patients with T2DM within 3 years of diagnosis, between serum vaspin concentration and the presence of carotid plaque.
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